Clinical and Imaging Findings in an Infant With Zika Embryopathy

Čuljat, Marko; Darling, Stephen; Nerurkar, Vivek R.; Ching, Natascha; Kumar, Mukesh; Min, Sarah K; Wong, Rupa; Grant, Leon; Melish, Marian E.

doi:10.1093/cid/ciw324

Cited by 80 publications

(79 citation statements)

References 35 publications

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“…Brain imaging reveals brain anomalies and ophthalmologic examination reveals visual disabilities. This proves that ZIKV possess enough potential to pass the placental barrier, infect fetal neural cells, multiply, and cause neurological damage to fetus [58] .…”

Section: Zikv Diagnosismentioning

confidence: 83%

Advances in research on Zika virus

Ali

Wahid

Rafique

et al. 2017

Asian Pacific Journal of Tropical Medicine

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Zika virus (ZIKV) is rapidly spreading across the America and its devastating outcomes for pregnant women and infants have driven this previously ignored pathogen into the limelight. Clinical manifestations are fever, joint pain or rash and conjunctivitis. Emergence of ZIKV started with a first outbreak in the Pacific area in 2007, a second large outbreak occurred in the Pacific in 2013/2014 and subsequently the virus spread in other Pacific islands. Threat of explosive global pandemic and severe clinical complications linked with the more immediate and recurrent epidemics necessitate the development of an effective vaccine. Several vaccine platforms such as DNA vaccine, recombinant subunit vaccine, ZIKV purified inactivated vaccine, and chimeric vaccines have shown potent efficacy in vitro and in vivo trials. Moreover, number of drugs such as Sofosbuvir, BCX4450, NITD008 and 7-DMA are ready to enter phase I clinical trial because of proven anti-ZIKV activity. Monoclonal based antibodies offer promise as an intervention effective for use in pregnant women. In this review, we describe the advances in research on ZIKV such as research strategies for the development of antiviral drugs & vaccines, molecular evolution, epidemiology emergence, neurological complications and other teratogenic outcomes as well as pathogenesis.

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Section: Zikv Diagnosismentioning

confidence: 83%

Advances in research on Zika virus

Ali

Wahid

Rafique

et al. 2017

Asian Pacific Journal of Tropical Medicine

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“…We recently demonstrated the first congenital ZIKV infected case in the United States, confirmed by high ZIKV IgM antibody titers in serum and cerebrospinal fluid [10]. In this case, a ZIKV-infected mother delivered a baby with microcephaly.…”

Section: Introductionmentioning

confidence: 85%

Prevalence of Antibodies to Zika Virus in Mothers from Hawaii Who Delivered Babies with and without Microcephaly between 2009-2012

et al. 2016

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Zika virus (ZIKV) is an emerging mosquito-borne pathogen. ZIKV infection is linked to the development of severe fetal abnormalities that include spontaneous abortion, stillbirth, hydranencephaly, and microcephaly. ZIKV outbreaks have been recorded in the United States. We recently demonstrated the first congenital ZIKV infection in the United States. In this study, we investigated archived blood samples from six mothers who gave birth to babies with microcephaly and 12 mothers who gave birth to healthy babies in Hawaii between 2009 and 2012. We tested maternal blood for the presence of ZIKV IgM and IgG antibodies using commercially available human ZIKV IgM and IgG ELISA kits. Blood from one mother who delivered babies with microcephaly tested positive for ZIKV IgM antibody (16.6%) and blood from three mothers tested positive for ZIKV IgG antibody (50%). ZIKV showed a trend toward significance with microcephaly. ZIKV IgG antibody positive mothers were more likely to deliver babies with microcephaly than mothers who were negative for ZIKV IgG antibodies (Odds ratio [OR] = 11.0, 95% confidence interval [CI] = 0.8–147.9, p = 0.083). Similarly, ZIKV IgM antibody positive mothers were also more likely to deliver babies with microcephaly than mothers who were negative for ZIKV IgM antibody (OR = 6.8, 95% CI = 0.2–195.1). These data provide further evidence of a link between ZIKV infection and microcephaly and suggests presence of ZIKV positive cases and associated microcephaly in the United States as early as 2009.

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“…Besides microcephaly, other CNS abnormalities associated with ZIKV infection include: 1) presence of extraaxial fluid; 2) abnormal gyral arrangement (polymicrogyria); 3) decreased brain parenchymal volume; 4) cortical atrophy and malformation; 5) hypoplasia of the cerebellum, vermis, or brain stem; 6) delayed myelination; and 7) thinning or hypoplasia of the corpus callosum (49,(54)(55)(56)67). Neurologic examination of ZIKV-infected children has demonstrated hypertonia, hypotonia, spasticity, hyperreflexia, severe irritability, and seizure (61,62).…”

Section: Neurologic Manifestationsmentioning

confidence: 99%

Zika Virus, Congenital Infection, and Neurologic Manifestations in Children: A Narrative Review

Karimi

Razavi

2017

J Pediatr Rev

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Context: Zika virus (ZIKV) is an arbovirus of the family Flaviviridae. This virus, which is transmitted by mosquitoes, usually affects children and causes self-limited diseases, associated with fever, maculopapular rash, conjunctivitis, arthralgia, and myalgia. There is a significant relationship between ZIKV infection and central nervous system disorders in infants. In this study, we aimed to review neurologic manifestations of ZIKV infection in infants. Evidence Acquisition: We searched the following Mesh terms in scientific databases: "Zika virus", "infants", "children", "neurologic manifestations", and "congenital infection". Electronic databases including Google Scholar, Science Direct, PubMed, Web of Science, Scientific Information Database, and Scopus were searched from 2000 to 2016. Results:The literature review showed a probable relationship between ZIKV infection and prevalence of microcephaly in newborns. Besides microcephaly, other central nervous system abnormalities included abnormal gyral arrangement, decreased brain parenchymal volume, cortical atrophy and malformation, cerebellar hypoplasia, and delayed myelination of the brain stem. Conclusions: Vertical transmission of ZIKV in pregnant women is associated with intrauterine infection and brain malformations in the developing fetus, including microcephaly, calcification, cortical displacement, ventriculomegaly, and white-matter abnormalities.

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Clinical and Imaging Findings in an Infant With Zika Embryopathy

Cited by 80 publications

References 35 publications

Advances in research on Zika virus

Advances in research on Zika virus

Prevalence of Antibodies to Zika Virus in Mothers from Hawaii Who Delivered Babies with and without Microcephaly between 2009-2012

Zika Virus, Congenital Infection, and Neurologic Manifestations in Children: A Narrative Review

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