Clinical and immunologic features of transient cold agglutinin hemolytic anemia

Jacobson, Lester B.; Longstreth, George F.; Edgington, Thomas S.

doi:10.1016/0002-9343(73)90047-8

Cited by 46 publications

(15 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study there was no significant difference in CATs in patients with or without evidence of M pneumoniae infection. Cold haemagglutination depends on the production of an IgM autoantibody to the erythrocyte I antigen during M pneumoniae infection (Jacobson et al, 1973). Autoimmune diseases are uncommon in Nigerians, perhaps related to immunological disturbances produced by parasitic infections (Greenwood, 1968), and this may explain the poor autoantibody production in our patients with M pneumoniae infection as reflected in low CATs.…”

Section: Discussionmentioning

confidence: 91%

Mycoplasma pneumoniae and the aetiology of lobar pneumonia in northern Nigeria.

Macfarlane¹,

Adegboye²,

Warrell³

1979

Thorax

View full text Add to dashboard Cite

Over a six-month period we studied 74 adult Nigerians who presented consecutively to Ahmadu Bello University Teaching Hospital, Zaria, with lobar or segmental pneumonia. Pneumococcal infection was diagnosed in 50% by the detection of pneumococcal polysaccharide antigen in serum or purulent sputum: 24% had pneumococcal antigenaemia. Twelve patients had evidence of Mycoplasma pneumoniae infection and half of these also had pneumococcal infection. The suggestion that M pneumoniae respiratory infection may predispose to serious bacterial pneumonia is discussed. The initial clinical and radiological features were similar in the pneumococcal and M pneumoniae groups. Raised cold agglutinin titres were not a reliable indication of M pneumoniae infection, perhaps due to altered autoantibody production in Nigerians. Pneumonia was commoner in the dry season, probably related to depressed nasopharyngeal defences caused by drying. Less common causes of lobar pneumonia that were found are also discussed and no cases of legionnaires' disease were identified.

show abstract

Section: Discussionmentioning

confidence: 91%

Mycoplasma pneumoniae and the aetiology of lobar pneumonia in northern Nigeria.

Macfarlane¹,

Adegboye²,

Warrell³

1979

Thorax

View full text Add to dashboard Cite

show abstract

“…Cold agglutinin might be formed in various diseases [6,7] such as idiopathic, malignant lymphoma, neoplasms, and infections [8,9] mainly such as Myco plasma pneumoniae, cytomegalovirus and Epstein-Barr virus.The presence of warm agglutinin antibody in the pa tient with chronic renal failure (CRF) has been reported earlier. However, this is the first case of the cold agglut inin associated with M. pneumoniae infection appearing in a patient with CRF derived from membranoproliferative glomerulonephritis (MPGN).…”

mentioning

confidence: 99%

A Case of Chronic Renal Failure Followed by Cold Agglutinin Due to <i>Mycoplasma pneumoniae</i>Infection

Shibasaki¹,

Gomi²,

Ohno³

et al. 1991

Nephron

View full text Add to dashboard Cite

“…This report adds one case to the 16 cases of atypical pneumonia with immunochemical studies of the associated cold agglutinin reported in the literature and reviewed previously [6]. Transient postinfectious cold ag glutinins are either polyclonal or restricted polyclonal when studied by immunoelectrophoresis and light-chain typing.…”

Section: Discussionmentioning

confidence: 87%

“…The cold agglutinin was electrophoretically heterogeneous with no suggestion of discrete restriction when examined by immunoelectrophoresis. The cold agglutinin did not react with a cold agglutinin idiotype-specific antiserum [6], t agglutinated adult group O, I-positive red cells but not I-negative cells. The ag glutinin was completely neutralized by the addition of boiled human milk [7].…”

Section: Case Reportmentioning

confidence: 82%

Pathogenesis of Anemia Associated with <i>Mycoplasma Pneumoniae</i>

Fiala¹,

Myhre²,

Chinh³

et al. 1974

Acta Haematol

View full text Add to dashboard Cite

A 46-year-old female infected with Mycoplasma pneumoniae developed severe pneumonia with hypoxia and anemia; both conditions responded promptly to erythromycin. The patient’s serum contained cold agglutinins at a high titer for 18 days; the agglutinins were polyclonal, cold agglutinin idiotypenegative, and predominantly blood group I-specific. During the acute phase of illness, the patient was anergic to tuberculin. It is suggested that, in addition to hemolysis, bone marrow suppression played an important role in the pathogenesis of the anemia in our patient.

show abstract

Clinical and immunologic features of transient cold agglutinin hemolytic anemia

Cited by 46 publications

References 31 publications

Mycoplasma pneumoniae and the aetiology of lobar pneumonia in northern Nigeria.

Mycoplasma pneumoniae and the aetiology of lobar pneumonia in northern Nigeria.

A Case of Chronic Renal Failure Followed by Cold Agglutinin Due to <i>Mycoplasma pneumoniae</i>Infection

Pathogenesis of Anemia Associated with <i>Mycoplasma Pneumoniae</i>

Contact Info

Product

Resources

About