Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic

Bandeira, António; Gois, Luana Leandro; Campos, Gúbio Soares; Sardi, Sílvia Inês; Yssel, Hans; Vieillard, Vincent; Autran, Brigitte; Grassi, Maria Fernanda Rios

doi:10.1016/j.bjid.2020.08.005

Cited by 11 publications

(9 citation statements)

References 25 publications

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“…Several studies demonstrate that the targets of this work have differential expression during the period of ZIKV infection, which therefore suggests the possible use of these markers to ascertain harm during infection by this virus (40)(41)(42).…”

Section: This Possible Relation Between Infection Time and Target Mrn...mentioning

confidence: 87%

Analysis of cytokine mRNA expression during Zika infection in Mesocricetus auratus

Mendes

Melo

Luna

et al. 2022

Preprint

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The Zika virus (VZIK) is a Flavivirus of the Flaviviridae family. With the ability to infect neural progenitor cells, microcephaly is the most serious and irreversible neurological complication associated with ZIKV. In this work, we evaluated the mRNA expression of cytokines involved in the inflammatory process that occurred during Zika virus infection in Mesocricetus auratus. The samples came from the real tissue of animals infected through sexual transmission and comprising 3 different groups of animals (TS-01, TS-02 and ZP-01).The project started with the extraction of viral RNA and mRNA from the kidneys of ZIKV-infected animals. After this step, RT-qPCR was carried out to quantify both the viral load and the expression of cytokines associated with the inflammatory process that occurred during the ZIKV infection. As can be seen in our results, this work corroborates different studies that demonstrate that ZIKV can infect and cause an inflammatory response to the kidneys, even causing a high viral load.

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Section: This Possible Relation Between Infection Time and Target Mrn...mentioning

confidence: 87%

Analysis of cytokine mRNA expression during Zika infection in Mesocricetus auratus

Mendes

Melo

Luna

et al. 2022

Preprint

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“…ZIKV belongs to the RNA virus in the Flaviviridae family, closely related to other flaviviruses, including DENV, West Nile virus, Japanese encephalitis virus, Chikungunya virus, and yellow fever virus ( Arora, 2020 ). Zika infection was closely related to CNS and PNS diseases, in particular stroke or transient ischemic attack, GBS ( Ferreira et al, 2020 ), meningoencephalitis, transverse myelitis ( Da Silva et al, 2017 ), retroorbital pain ( Sharma et al, 2020 ), and myalgia ( Bandeira et al, 2020 ). Evidence has shown a close relationship between Zika infection during pregnancy, congenital abnormalities, and microcephaly ( Mlakar et al, 2016 ).…”

Section: Neurological Manifestations Of Emerging Infectious Diseasesmentioning

confidence: 99%

Modulating Neurological Complications of Emerging Infectious Diseases: Mechanistic Approaches to Candidate Phytochemicals

et al. 2021

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Growing studies are revealing the critical manifestations of influenza, dengue virus (DENV) infection, Zika virus (ZIKV) disease, and Ebola virus disease (EVD) as emerging infectious diseases. However, their corresponding mechanisms of major complications headed for neuronal dysfunction are not entirely understood. From the mechanistic point of view, inflammatory/oxidative mediators are activated during emerging infectious diseases towards less cell migration, neurogenesis impairment, and neuronal death. Accordingly, the virus life cycle and associated enzymes, as well as host receptors, cytokine storm, and multiple signaling mediators, are the leading players of emerging infectious diseases. Consequently, chemokines, interleukins, interferons, carbohydrate molecules, toll-like receptors (TLRs), and tyrosine kinases are leading orchestrates of peripheral and central complications which are in near interconnections. Some of the resulting neuronal manifestations have attracted much attention, including inflammatory polyneuropathy, encephalopathy, meningitis, myelitis, stroke, Guillain-Barré syndrome (GBS), radiculomyelitis, meningoencephalitis, memory loss, headaches, cranial nerve abnormalities, tremor, and seizure. The complex pathophysiological mechanism behind the aforementioned complications urges the need for finding multi-target agents with higher efficacy and lower side effects. In recent decades, the natural kingdom has been highlighted as promising neuroprotective natural products in modulating several dysregulated signaling pathways/mediators. The present study provides neuronal manifestations of some emerging infectious diseases and underlying pathophysiological mechanisms. Besides, a mechanistic-based strategy is developed to introduce candidate natural products as promising multi-target agents in combating major dysregulated pathways towards neuroprotection in influenza, DENV infection, ZIKV disease, and EVD.

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“…Zika virus (ZIKV) is an arthropod-borne flavivirus that may cause illness of high morbidity and mortality in humans, which poses unique challenges for the public health and economy of many countries [ 1 ]. In general, ZIKV infection causes a broad variety of non-specific clinical manifestations [ 2 ]. However, during pregnancy, ZIKV infection is associated with congenital brain malformations, placental insufficiency, intrauterine growth restriction, and even fetal death [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Increased Serum Levels of Growth-Differentiation Factor 3 (GDF3) and Inflammasome-Related Markers in Pregnant Women during Acute Zika Virus Infection

Alves

Melo

Silva

et al. 2022

Viruses

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The systemic inflammatory response elicited by acute Zika virus (ZIKV) infection during pregnancy plays a key role in the clinical outcomes in mothers and congenitally infected offspring. The present study aimed to evaluate the serum levels of GDF-3 and inflammasome-related markers in pregnant women during acute ZIKV infection. Serum samples from pregnant (n = 18) and non-pregnant (n = 22) women with acute ZIKV infection were assessed for NLRP3, IL-1β, IL-18, and GDF3 markers through an enzyme-linked immunosorbent assay. ZIKV-negative pregnant (n = 18) and non-pregnant women (n = 15) were used as control groups. All serum markers were highly elevated in the ZIKV-infected groups in comparison with control groups (p < 0.0001). Among the ZIKV-infected groups, the serum markers were significantly augmented in the pregnant women in comparison with non-pregnant women (NLRP3 p < 0.001; IL-1β, IL-18, and GDF3 p < 0.0001). The IL-18 marker was found at significantly higher levels (p < 0.05) in the third trimester of pregnancy. Bivariate and multivariate analyses showed a strong positive correlation between GDF3 and NLRP3 markers among ZIKV-infected pregnant women (r = 0.91, p < 0.0001). The findings indicated that acute ZIKV infection during pregnancy induces the overexpression of GDF-3 and inflammasome-related markers, which may contribute to congenital disorders and harmful pregnancy outcomes.

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Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic

Cited by 11 publications

References 25 publications

Analysis of cytokine mRNA expression during Zika infection in Mesocricetus auratus

Analysis of cytokine mRNA expression during Zika infection in Mesocricetus auratus

Modulating Neurological Complications of Emerging Infectious Diseases: Mechanistic Approaches to Candidate Phytochemicals

Increased Serum Levels of Growth-Differentiation Factor 3 (GDF3) and Inflammasome-Related Markers in Pregnant Women during Acute Zika Virus Infection

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