Clinical and magnetic resonance imaging features of multiple sclerosis with autoreactive antibodies in Ishikawa Prefecture, Japan

Takahashi, Kazuya; Tanaka, Keiko

doi:10.1016/j.jneuroim.2012.05.017

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…One study investigated the spinal cord of patients with NMO using axial magnetic resonance imaging (MRI) and found that over 60% of lesions exhibited T2-hyperintense regions that comprised of more than 50% of the cord area, and that these regions were mainly located in the central grey matter [20]. In relation to other autoimmune diseases and auto-reactive antibodies, 70% of patients with NMO have at least one auto-reactive antibody (except for NMO-IgG), and thus it seems that systemic autoimmune diseases including SLE are fairly similar to NMO [25].…”

Section: Neuromyelitis Opticamentioning

confidence: 99%

Systemic Lupus Erythematosus with Neuromyelitis Optica

Takahashi¹

2014

J Clin Cell Immunol

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Systemic lupus erythematosus (SLE) is an autoimmune disease that can have detrimental effects on many different systems in the body, including the central nervous system. Neuropsychiatric SLE (NPSLE) refers to several different neurological and/or behavioral clinical syndromes, and has been reported as having a prevalence rate of approximately 30−40%, while manifestation of myelitis or optic neuritis of NPSLE is rare (~1%). Myelitis and optic neuritis are easily identifiable since myelitis is frequently transverse, and manifests as severe disturbances in both motor and sensory pathways, while optic neuritis is often both bilateral and severe. At least 85% of patients experience relapses in the form of optic neuritis, transverse myelitis, or both. Furthermore, some cases of NPSLE with optic neuritis are often complicated by myelitis. Interestingly, the characteristics of myelitis or optic neuritis in NPSLE are quite similar to neuromyelitis optica (NMO), a disease characterized by bilateral optic neuropathy and transverse myelopathy. In fact, magnetic resonance imaging (MRI) of patients with NPSLE has demonstrated longitudinal spinal involvement showing cord swelling and hyperintense lesions in central regions. These findings are also typically observed in MRIs of patients with NMO. Additionally, anti-aquaporin 4 (AQP4) antibodies have been discovered in patients with NMO and with NPSLE with myelitis and/or optic neuritis. Therefore, complications that are often encountered with NMO should be considered when treating cases of NPSLE with myelitis and/or optic neuritis. Moreover, since the treatment of NMO closely resembles the therapeutic approaches taken for NPSLE, corticosteroids alone or in combination with immunosuppressants could prove effective in reducing incidents of relapse. Some patients, however, may be refractory to steroid therapy; in such cases, plasma exchange may have priority over other second-line therapeutic strategies, such as intravenous immunoglobulin and rituximab, because of treatment approaches typically employed in NMO. In this review, I will discuss pathological similarities between NPSLE with myelitis and/or optic neuritis and NMO with the aim of demonstrating that our knowledge of NMO should be considered when treating NPSLE with myelitis and/or optic neuritis.

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Section: Neuromyelitis Opticamentioning

confidence: 99%

Systemic Lupus Erythematosus with Neuromyelitis Optica

Takahashi¹

2014

J Clin Cell Immunol

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Anti-thyroid antibodies and cerebrospinal fluid findings in neuromyelitis optica spectrum disorders

Dai

et al. 2015

Journal of Neuroimmunology

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Microglial heterogeneity in amyotrophic lateral sclerosis

Takahashi¹

2022

Journal of Neuropathology &Amp; Experimental Neurology

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Amyotrophic lateral sclerosis (ALS) is an intractable neurodegenerative disease of the central nervous system that is pathologically characterized by motor neuron loss. Although the cause of the disease is still unknown, its pathophysiology is considered heterogeneous. In recent years, there have been a series of reports on the existence of disease-associated microglia (DAM) in the lesions of various neurodegenerative diseases. DAM have also been reported in SOD1-deficient mice, a disease model of ALS. However, the role of DAM in sporadic ALS remains unclear. This study revealed that spinal cord lesions in ALS can be pathologically distinguished into 2 subgroups (TMEM119+ and TMEM119− microglia) according to the type of microglia. Expression of the microglial activation marker CD68 and endothelial activation were also observed in the TMEM119+ microglia group, suggesting the presence of inflammatory processes in ALS lesions. Since DAM suppress the expression of TMEM119, the TMEM119+ microglia group may indicate DAM-independent inflammatory neurodegeneration. These results may explain why, in some clinical trials of anti-inflammatory drugs for ALS, only some cases showed suppression of disease progression.

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Clinical and magnetic resonance imaging features of multiple sclerosis with autoreactive antibodies in Ishikawa Prefecture, Japan

Abstract: Previous reports of multiple sclerosis (MS) with autoantibodies might include neuromyelitis optica (NMO). We investigated the frequency of autoreactive antibodies

Cited by 3 publications

References 31 publications

Systemic Lupus Erythematosus with Neuromyelitis Optica

Systemic Lupus Erythematosus with Neuromyelitis Optica

Anti-thyroid antibodies and cerebrospinal fluid findings in neuromyelitis optica spectrum disorders

Microglial heterogeneity in amyotrophic lateral sclerosis

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