Clinical and microbiological characteristics of Eggerthella lenta bacteremia at a Japanese tertiary hospital

Nagaoka, Rie; Kitagawa, Hirohisa; Koba, Yumiko; Tadera, Kayoko; Hara, Takatoshi; Kashiyama, Seiya; Nomura, Toshihito; Omori, Keitaro; Shigemoto, Norifumi; Yokozaki, Michiya; Ohge, Hiroki

doi:10.1016/j.jiac.2021.03.019

Cited by 7 publications

(5 citation statements)

References 11 publications

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“…Byun et al (2019) showed resistance to penicillin and moxifloxacin [14]. Other studies found E. lenta to be resistant to piperacillin/tazobactam but susceptible to carbapenems and metronidazole which is in line with our results [31,32].…”

Section: Discussionsupporting

confidence: 92%

Antimicrobial Susceptibility Profile of Rare Anaerobic Bacteria

Wolf

Stingu

2022

Antibiotics

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Anaerobes play an important role in clinically relevant infections and resistance is increasing worldwide. We tested 120 rare anaerobic isolates belonging to 16 genera for antimicrobial resistance using the agar dilution method and compared those results to the time-saving E-test method. The susceptibility data for 12 antimicrobial substances (benzylpenicillin, ampicillin/sulbactam, piperacillin/tazobactam, imipenem, meropenem, cefoxitin, metronidazole, moxifloxacin, clindamycin, doxycycline, tigecycline, eravacycline) were collected. Susceptibility testing showed low resistance to β-lactam/β-lactamase inhibitor combinations and no resistance to carbapenems and tigecycline. We observed moderate to high rates of resistance to moxifloxacin and clindamycin which differed depending on the methodology used. The essential and categorical agreement was over 90% for ampicillin/sulbactam, meropenem, moxifloxacin, and tigecycline. For metronidazole and clindamycin, the essential agreement was below 90% but the categorical agreement was near or above 90%. Penicillin presented with the lowest categorical agreement of 86.7% and a very high very major error rate of 13.3%. The resistance rates reported in this study are concerning and show the importance of routine susceptibility testing. Further investigations are necessary to determine the reason for high error rates and how to improve susceptibility testing of fastidious anaerobes.

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Section: Discussionsupporting

confidence: 92%

Antimicrobial Susceptibility Profile of Rare Anaerobic Bacteria

Wolf

Stingu

2022

Antibiotics

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“…The patient had no other focus of bacteremia, including intra-oral infection, besides pyometra. Cases of bacteremia caused by E. clostridioformis or E. lenta in a patient with pyometra have been reported [ 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

A case of bacteremia caused by Dialister micraerophilus with Enterocloster clostridioformis and Eggerthella lenta in a patient with pyometra

Kitagawa,

Tadera,

Omori

et al. 2024

BMC Infect Dis

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Background Infection by Dialister micraerophilus, an obligate anaerobic gram-negative bacillus, has rarely been described, and its clinical characteristics remain unclear. Case presentation We report a case of bacteremia caused by D. micraerophilus, Enterocloster clostridioformis, and Eggerthella lenta in a 47-year-old woman, associated with pyometra. D. micraerophilus was identified using 16S rRNA gene sequencing and matrix-assisted laser desorption ionization time-of-flight mass spectrometry. D. micraerophilus was detected by polymerase chain reaction using D. micraerophilus-specific primers and E. clostridioformis and E. lenta was isolated from the drainage pus sample obtained from the pyometra uterus. The patient achieved a cure after abscess drainage and 2-week antibiotic treatment. Conclusions To the best of our knowledge, this is the first report of D. micraerophilus bacteremia. D. micraerophilus may be associated with gynecological infections. Clinicians should consider both oral and gynecological sites when searching to identify the focus of D. micraerophilus infection.

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“…Another study done in UK identified E. lenta causing bacteraemia as a complication of percutaneous nephrostomy. Therefore, reliable laboratory investigations are required for prompt identification of E. lenta to start optimal treatment as early as possible [12]. Even today the gold standard method for the diagnosis of E. lenta bacteremia is blood culture followed by bacterial identification with using matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) [12].…”

Section: Discussion/conclusionmentioning

confidence: 99%

“…Therefore, reliable laboratory investigations are required for prompt identification of E. lenta to start optimal treatment as early as possible [12]. Even today the gold standard method for the diagnosis of E. lenta bacteremia is blood culture followed by bacterial identification with using matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) [12]. According to Table 1 all similar case reports of E. lenta used blood culture as the preferred method of diagnosis.…”

Section: Discussion/conclusionmentioning

confidence: 99%

An unusual case of empyema with septicaemia secondary to eggerthella lenta

Hussain¹,

Hamdallah²,

Ponnuswamy³

2022

J Clin Images Med Case Rep

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Eggerthella lenta is an anaerobic, non-spore-forming, nonmotile, gram-positive bacillus commensal in human intestine. It causes genitourinary tract infection, abscess, and wound infection but can lead to disseminated life-threatening septicemia. Risk factors to develop infection secondary to E. Lenta are immunocompromised and elderly patients with pre-existing co-morbidities such as cancer and diabetes mellitus.

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Clinical and microbiological characteristics of Eggerthella lenta bacteremia at a Japanese tertiary hospital

Cited by 7 publications

References 11 publications

Antimicrobial Susceptibility Profile of Rare Anaerobic Bacteria

Antimicrobial Susceptibility Profile of Rare Anaerobic Bacteria

A case of bacteremia caused by Dialister micraerophilus with Enterocloster clostridioformis and Eggerthella lenta in a patient with pyometra

An unusual case of empyema with septicaemia secondary to eggerthella lenta

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