Clinical and microbiological effects of different antimicrobials on generalized aggressive periodontitis

Xajigeorgiou, Christiana; Sakellari, Dimitra; Slini, Theodora; Baka, Anneta; Konstantinidis, Antonis

doi:10.1111/j.1600-051x.2006.00905.x

Cited by 141 publications

(286 citation statements)

References 46 publications

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“…Although OHI brought about a significant reduction in VPI, this was not enough to change the subgingival microbiota profile. This finding contradicts a previous hypothesis that a decrease in gingival inflammation and gingival crevicular fluid flow will result in reduced nutrition for subgingival plaque after supragingival plaque control (35,36).…”

Section: Discussioncontrasting

confidence: 98%

Comparison of nonsurgical periodontal therapy with oral hygiene instruction alone for chronic periodontitis

et al. 2017

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We evaluated changes in clinical variablesand microbiological profiles of periodontopathogens among 56 patients with moderate to severe CP who were randomly assigned to oral hygiene instruction (OHI; n = 28) or nonsurgical periodontal treatment (NSPT; n = 28). Periodontal variables were assessed and subgingival plaque samples were obtained from deep pockets (≥5 mm) at baseline and 3 months after treatment. Real-time polymerase chain reaction was used to quantify Actinobacillus actinomycetemcomitans, Tannerella forsythia, Porphyromonas gingivalis, and Prevotella intermedia. All clinical variables significantly improved in both groups. Improvements in gingival bleeding index (GBI), probing pocket depth (PPD), and periodontal attachment loss (PAL) were significantly greater at 3 months after treatment in the NSPT group. At baseline, the prevalences of all pathogens were high. Significant reductions in microbial count were observed for A. actinomycetemcomitans and T. forsythia (P ≤ 0.05) in the NSPT group. None of the improvements in clinical variables was associated with changes in microbiological profiles. At 3 months after treatment, NSPT was associated with significantly greater improvements in GBI, PPD, and PAL as compared with OHI. A. actinomycetemcomitans and T. forsythia counts were significantly lower in the NSPT group.

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Section: Discussioncontrasting

confidence: 98%

Comparison of nonsurgical periodontal therapy with oral hygiene instruction alone for chronic periodontitis

et al. 2017

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“…The association of amoxicillin and metronidazole or metronidazole only provided a beneficial effect on clinical (PD) and microbiological outcomes. Doxycycline, however, failed to demonstrate benefits to conventional therapy in patients with generalized AP 41 . On the other hand, Machtei et al 42 when compared the effect of doxycycline and amoxicillin + metronidazole as adjuncts to the non-surgical therapy, found similar improvements in clinical and immunological parameters evaluated, recommending the use of both antibiotic regimes.…”

Section: Antibioticsmentioning

confidence: 97%

Auxiliary chemical therapies in the treatment of aggressive periodontitis: current aspects

Ayub

Júnior

Grisi

et al. 2015

RGO, Rev. Gaúch. Odontol.

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Aggressive periodontitis, a distinct clinical entity of periodontal disease, is characterized by a pronounced episodic and rapid destruction of periodontal tissues and may result in rapid and RESUMOA periodontite agressiva, uma entidade clínica distinta da doença periodontal, é caracterizada por uma pronunciada destruição episódica e rápida dos tecidos periodontais e pode resultar em perda rápida e precoce dos dentes. Alguns trabalhos têm mostrado que o debridamento mecânico convencional juntamente com higiene oral muitas vezes não é suficiente para o controle da doença. Apesar de não existir consenso, estudos recentes desta condição mostram efeitos benéficos de terapias auxiliares ou coadjuvantes como a administração de antimicrobianos sistêmicos e locais. Entre os coadjuvantes locais, a literatura apresenta os antissépticos, antibióticos e terapia fotodinâmica. Dentre os sistêmicos são representados os antibióticos e antiinflamatórios. Independentemente dos resultados apresentados por cada um deles, se reconhece a dificuldade em se estabelecer um protocolo único para todos os casos em função da resposta individual apresentada por cada paciente. O objetivo do presente estudo foi revisar os resultados atuais sobre administração de coadjuvantes químicos associados à terapia convencional em casos de periodontite agressiva e sugerir protocolos clínicos.Termos de indexação: Periodontite agressiva. Antibacterianos. Anti-infecciosos locais. Antissépticos bucais. Anti-inflamatórios. Fotoquimioterapia. and alveolar bone destruction and c) family concentration of cases. The diagnosis of AP requires the exclusion of systemic diseases that may harm the host defense and lead to premature teeth loss (periodontal manifestations of systemic diseases). Auxiliary chemical therapies in the treatment of aggressive periodontitis: current aspectsThe existence of particular forms of AP was also recognized based on specific clinical and lab characteristics: localized aggressive periodontitis (LAP) and generalized aggresssive periodontitis (GAP) 2 .A successful treatment of AP is dependent of early diagnosis, directing the therapy to the elimination or deletion of pathogens, providing a favorable

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“…Çünkü yalnız mekanik tedavi uygulanarak uzun dönem bakterilerin rekolonizasyonu engellenemediği için ilave terapödik tedaviye ihtiyaç vardır. 36 Literatürde; cerrahi, cerrahi olmayan tedavi tetrasiklinli, tetrasiklinsiz tedavi rejimleri yapılan çalışmalarla karşılaştırılmıştır. Cerrahi tedavi ve sadece tetrasiklin kullanımı sonucunda; periodontal patojenlerde, kanamada, cep derinliğinde azalma olduğu tespit edilmiştir.…”

Section: Cerrahi Olmayan Metodunclassified

Aggressive Periodontitis

大澤¹,

仲谷²,

鴨井³

2018

Diseases and Conditions in Dentistry

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Clinical and microbiological effects of different antimicrobials on generalized aggressive periodontitis

Abstract: Adjunctive metronidazole plus amoxicillin or metronidazole alone (when A.actinomycetemcomitans is not involved) is effective in deep pockets of aggressive periodontitis patients.

Cited by 141 publications

References 46 publications

Comparison of nonsurgical periodontal therapy with oral hygiene instruction alone for chronic periodontitis

Comparison of nonsurgical periodontal therapy with oral hygiene instruction alone for chronic periodontitis

Auxiliary chemical therapies in the treatment of aggressive periodontitis: current aspects

Aggressive Periodontitis

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