Clinical and microbiological evaluation of the effect of Lactobacillus reuteri in the treatment of mucositis and peri‐implantitis: A triple‐blind randomized clinical trial

Abstract

The administration of a daily lozenge of L. reuteri for 30 days, together with mechanical debridement of the whole mouth, improved the clinical parameters of implants with mucositis or peri-implantitis over a period of at least 90 days, but the microbiological effect was much more limited. Probiotics provide an alternative therapeutic approach to consider in the prevention and treatment of peri-implant diseases, but further long-term prospective studies with standardized variables are needed.

Heat‐killed Lactobacillus reuteri and cell‐free culture supernatant have similar effects to viable probiotics during interaction with Porphyromonas gingivalis

“…The major mechanisms of action of probiotics are epithelial barrier enhancement, increased adhesion to intestinal mucosa, pathogen adhesion inhibition, competitive exclusion of pathogenic microorganisms, production of anti‐microorganism substances, and modulation of the immune system . The inhibition of P gingivalis growth by L reuteri has been already reported, both in vitro and in vivo . Our in vitro results corroborate the literature findings in regard to the effective antibacterial action of live L reuteri .…”

“…In periodontics, after the use of L reuteri in patients with periodontitis or peri‐implantitis, a decrease in probing depth, bleeding on probing, and decreased gingival and plaque index, or an increase in the clinical attachment level was found . In both in vitro and in vivo studies, L reuteri inhibits the growth of Porphyromonas gingivalis.…”

Efficacy of mechanical debridement with adjunctive probiotic therapy in the treatment of peri‐implant mucositis in cigarette‐smokers and never‐smokers

“…4,5 The patients were instructed to use one lozenge every 12 hours, twice a day for 3 weeks, after tooth brushing. Probiotics (Gum PerioBalance-Sunstar Etoy Switzerland) were administered in the form of lozenges that contained active units of 2 L. reuteri strains (1 × 10 8 CFU of ATCC PTA 5289, and 1 × 10 8 CFU of DSM 17938) as described in previous studies.…”

“…11,12 These explanations have been associated with compromised outcomes of surgical and nonsurgical oral therapeutic interventions in individuals smoking tobacco-products compared with never-smokers. To date, clinical studies 4,5,9,15 that have investigated the role of MD with adjunctive PD in the management of PiM have been followed-up for a maximum duration of 90 days. To date, clinical studies 4,5,9,15 that have investigated the role of MD with adjunctive PD in the management of PiM have been followed-up for a maximum duration of 90 days.…”

Probióticos associados ao tratamento das doenças periodontais: revisão de literatura

“…Mas, empregando os Lactobacillus reuteri (durante 30 dias) adjunto à terapia não cirúrgica em pacientes com mucosite ou peri-implantite e história prévia de DP, o grupo experimental (n: 22) obteve melhores condições clínicas: para os pacientes com mucosite, redução do sangramento; para os pacientes com peri--implantite, redução da profundidade de sondagem; até 90 dias. Os probióticos testados não reduziram significativamente a carga bacteriana analisada no estudo, apenas houve decréscimo nos implantes com peri-implantite no nível de Porphyromonas gingivalis, sendo que foram analisados: Aggregibacter actinomycetemcomitans, Tannerella forsythia, Treponema denticola, Prevotella intermedia, Peptostreptococcus micros, Fusobacterium nucleatum, Campylobacter rectus e Eikenella corrodens; todos foram semelhantes ao grupo placebo 50 .…”