Clinical and Microbiological Features of Infection with Malassezia pachydermatis in High-Risk Infants

Mickelsen, Patricia A.; Viano-Paulson, Mary C.; Stevens, David A.; Diaz, Pamela S.

doi:10.1093/infdis/157.6.1163

Cited by 86 publications

(59 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The results of the Etest® obtained in this work for the MICs had a broader range, higher values and an average MIC higher than the values reported by Coutinho (7,8). This author found a mean MIC 0.08 µg/mL (0.015 to 0.25 µg/mL) and MIC values lower than the data obtained by Uchida et al (28) that ranged from 0.002 µg/mL to 10 µg/mL, but similar to the values obtained by Lorenzini et al (17), Mickelsen et al (20).…”

Section: Resultssupporting

confidence: 85%

Evaluation of Malassezia pachydermatis antifungal susceptibility using two different methods

Nascente

Nobre

Schuch

et al. 2003

Braz. J. Microbiol.

View full text Add to dashboard Cite

Malassezia pachydermatis is recognized as a normal inhabitant and an opportunistic pathogen of the external ear canal and skin of dogs and cats. In especial clinical conditions, and mainly in the cases of therapeutic failure related to external otitis and dermatitis complicated by this yeast, it is recommended test susceptibility to antifungal drugs. The purpose of this work was to evaluate the susceptibility of 44 isolates of M. pachydermatis from the external ear canal and skin of dogs and cats using two different in vitro antifungal susceptibility methods: the Etest® and the broth microdilution method. Thirty-five samples were tested using the Etest®, twenty-four samples were tested using the broth microdilution method and fifteen samples were tested using both tests. The antifungal agents used were ketoconazole (KTZ), fluconazole (FLZ) and itraconazole (ITZ). In the broth microdilution method the yeast was less susceptible to ITZ while KTZ had the strongest activity. On the other hand, the Etest® showed that M. pachydermatis was more susceptible to ITZ while the less active drug was FLZ. The simultaneous evaluation using both methods identified FLZ as the antifungal drug with the highest activity (64.3%), followed by KTZ (57.1%) and ITZ (28.6%). These results showed that there is an urgent need to standardize of the values considered as parameters for growth inhibition of this yeast so a simple and efficient method can be used routinely in the laboratory practice.

show abstract

Section: Resultssupporting

confidence: 85%

Evaluation of Malassezia pachydermatis antifungal susceptibility using two different methods

Nascente

Nobre

Schuch

et al. 2003

Braz. J. Microbiol.

View full text Add to dashboard Cite

show abstract

“…However, this species has also been reported to be associated with systemic infections in humans (Gu6ho et al 1987a, b;Gu6ho & Meyer 1989), and has been isolated from neonates (Larocco et al 1988;Mickelsen et al 1988). The recently described third species, Malassezia syrnpodialis, has been isolated from the auditory tract of a healthy person, as well as from tinea capitis from an AIDS patient (Simmons & Gu6ho 1990).…”

Section: Speciesmentioning

confidence: 99%

The use of karyotyping in the systematics of yeasts

Boekhout¹,

Renting

Scheffers

et al. 1993

Antonie van Leeuwenhoek

View full text Add to dashboard Cite

The use of electrophoretic karyotyping in systematics of yeasts is discussed. New data are provided on the karyotypes of the medically important fungi Hortaea werneckii, Filobasidiella (= Cryptococcus) neoformans, and Malassezia species. Hortaea werneckii has twelve to eighteen bands of chromosomal DNA, ranging in size between 500 and 2300 kb. The karyotypes of Filobasidiella neoformans consist of seven to fourteen bands of chromosomal DNA. The varieties neoformans and bacillispora cannot be separated by their karyotypes, and no obvious correlation was found with serotypes, geography or habitat. All strains of Malasseziapachydermatis studied have similar karyotypes consisting of five bands, whereas in M. furfur, four different karyotypes are prevalent. However, each of these karyotypes is stable.

show abstract

“…Biofilms, with the ability of producing an extracellular matrix, acts as a barrier against the influence of drugs (1)(2)(3)(4)(5). Although Malassezia genus is part of the skin normal flora, under certain conditions, becomes pathogenic and in the recent years has been reported as an emerging pathogen (1,(6)(7)(8)(9). The ability of these fungi in colonization on the catheter is associated with biofilm formation.…”

Section: Introductionmentioning

confidence: 99%