Clinical and microbiological profile of infective keratitis and their antibiotic sensitivity

Waghmare, Ashwini; Sadanand, Praveen Kumar

doi:10.18231/2394-5478.2019.0003

Cited by 3 publications

(6 citation statements)

References 2 publications

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“…Present study the percentage of males affected 68.8% compared to females affected 31.2% and male female ratio 2.2:1, males were more affected may be due to more exposure outdoors and hard labour in dry dusty areas. This was in accordance with studies done by Waghmare AS et al, 11 Metha S et al, 13 Jayashree MP et al 16 Agricultural workers (50.3%) were most affected people in the present study due to exposure to the vegetative injuries because of nature of work, this was in line with studies done by Metha S et al 13 Vasudha CL, 15 Jayashree MP et al 16 Predisposing factors such as corneal trauma in our study was 54.12% followed by diabetes 34%, this finding was comparable with studies done by Waghmare AS et al, 11 Sharmila Raut et al, 12 Metha S et al, 13 Suwal S, 17 Gotekar R. B et al, 14 Jayashree MP et al, 16 Tarekegn Wuletaw et al 18 Percentage of vegetative trauma was 54.25% followed by Sand and dust 15.2%. Similar findings are seen in most of the studies done.…”

Section: Discussionsupporting

confidence: 94%

“…In the present study incidence of corneal ulcer was seen most common in age group 21-40 years with 44.9% followed by 41-60years with 33.02% Which is supposed to be comparable with studies conducted by Amrutha KB et al, 10 Waghmare AS et al, 11 Sharmila Raut et al, 12 Metha S et al, 13 Gotekar R. B et al, 14 where as Vasudha CL 15 study had 41-50 years as most common age group with 38.8%, Gotekar R.B et al 14 study stated 56-70 years as most affected age group with 35%.…”

Section: Discussionsupporting

confidence: 92%

“…Most common fungal isolate was fusarium followed by aspergillus spp similar findings were seen in studies conducted by Vasudha CL et al, 15 Waghmare AS et al, 11 while Sharmila Raut et al 12 study showed aspergillus as most common fungal isolate with 39.3%…”

Section: Discussionsupporting

confidence: 76%

“…Most common bacterial isolate was streptococcus pneumoniae(34.3%) followed by staphylococcus aureus (17.9%) which was comparable with Vasudha CL, 15 Jayashree MP et al, 16 whereas study done by Reena Anie Jose et al 20 showed staphylococcus epidermidis and Waghmare AS et al 11 showed staphylococcus aureus to be the most common bacterial isolate.…”

Section: Discussionsupporting

confidence: 63%

“…Similar findings are seen in most of the studies done. In a study done by Vasudha CL 15 vegetative trauma was 27.7% diabetes 16.6%, Waghmare AS et al, 11 Sharmila Raut et al 12 30% and 36% respectively.…”

Section: Discussionmentioning

confidence: 93%

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Microbiological profile of infective keratitis in a tertiary care hospital in north Karnataka

Biradar¹,

Nigudgi²,

Doddamani³

et al. 2021

IJMR

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Corneal blindness is seen worldwide with 1.5 to 2 million new cases reported every year and approximately there are 6.8 million cases of corneal blindness in India. The study constituted 109 clinically diagnosed infective keratitis cases. Aseptically collected corneal scrapings are subjected to Gram stain, KOH wet mount & Culture. Further identification done by study of Colony morphology, staining & biochemical tests. Antibiotic sensitivity was found using Kirby buer’s disc diffusion method following CLSI guidelines. Males affected more common than females. Common age group being 21-40 yrs. Infective keratitis is usually Bacterial(61.4%) in origin than fungal(22%). Trauma found to be the most common predisposing factor followed by diabetes, other ocular diseases, surgery & corticosteroid therapy. Trauma with vegetative material is most common. Streptococcus pneumonia & pseudomonas are most common bacterial cause while Fusarium & Aspergillus cause most fungal cases. Infective keratitis both bacterial & fungal are more common in working males, mainly agriculturists who are exposed to vegetative trauma. Early detection and treatment with proper antibacterial & antifungals is important to prevent ocular problems and scarring of cornea.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 76%

Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 93%

See 3 more Smart Citations

Microbiological profile of infective keratitis in a tertiary care hospital in north Karnataka

Biradar¹,

Nigudgi²,

Doddamani³

et al. 2021

IJMR

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The Clinical and Microbiological Characteristics of Fungal Keratitis in COVID-19 Period

Sankolli,

Biradar,

Shahapur

et al. 2024

Journal of Datta Meghe Institute of Medical Sciences University

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Context: In India, the incidence of fungal keratitis ranges from 44% to 47%, due to its tropical environment and huge at-risk agricultural population. The emergence of COVID-19 has influenced the medical management of fungal keratitis. Aim: The aim of this study was to assess the clinical and microbiological characteristics of fungal corneal ulcers during COVID-19 period. Settings and Design: This was a cross-sectional study of 1-year duration. Subjects and Methods: Fifty-two KOH mount-positive and fungal culture-positive patients were included in the study. Ophthalmic examination, including best-corrected visual acuity, slit-lamp examination, fluorescent staining was done, Anterior segment optical coherence tomography (ASOCT). Corneal scraping was sent for 10% KOH mount and fungal cultures with Sabouraud’s dextrose agar for growth. Statistical Analysis Used: The Statistical Package for the Social Sciences (Version 20) was used for statistical analysis. Results: Fifty-two KOH mount and fungal culture-positive patients were included, with a mean age of 50.88 years. 53.8% were farmers. 55.6% had a history of trauma with organic matter. The common signs noted were an irregular, dry looking, central corneal ulcer measuring 2-5mm extending 20-50% deep, mid stromal infiltration, satellite lesions and surrounding stromal oedema. Eleven presented with perforation. The best-corrected visual acuity was hand movements (32.7%). The KOH mount positive among the screened patients was 46.7%, of which 52 were culture positive. Aspergillus fumigatus (61.5%) was the predominant cause of mycotic keratitis. Conclusion: Mycotic keratitis was mostly caused by filamentous fungus and was most frequently observed among farmers. COVID-19 has increased the cases of perforated corneal ulcers, and ASOCT was the noninvasive, feasible tool to assess the cornea.

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Microbial Spectrum of Keratitis at a Rural Tertiary Care Teaching Hospital

Bhagath,

Prasad,

Natarajan

2024

Cureus

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Introduction: Microbial keratitis poses a significant threat to vision and is a common ocular infection. Its causative agents encompass a wide spectrum, including bacteria, fungi, viruses, and parasites. The microbiological profile of microbial keratitis is influenced by factors such as patient demographics, geographical location, climate, and occupational hazards and evolves over time. Methodology: Corneal scrapings were collected from 75 patients with a provisional diagnosis of microbial keratitis. The samples were processed in the microbiology laboratory, and the bacterial and fungal growth isolated in the study were identified according to standard procedures. Results: Among the 75 patients, 48 (64%) were male and 27 (36%) were female. Corneal ulceration was found in individuals of all age groups, with the highest prevalence of 77.33% (58/75) observed in the 21-60 age range. Farmers exhibited a higher susceptibility, constituting 66.67% (50/75) of the cases. The study noted a higher occurrence of keratitis from November to February, accounting for 69.33% (52/75). Microbial etiology was identified in 25.33% (19/75) of scrapings, with fungi accounting for 68.42% (13/19) and bacteria for 31.57% (6/19). The prevalent fungal species included Fusarium (7/13, 53.84%), Aspergillus (3/13, 23.07%), Colletotrichum (2/13, 15.38%), and Curvularia (1/13, 7.69%). Bacterial isolates featured Streptococcus pneumoniae (5/6, 83.33%) and Klebsiella pneumoniae (1/6, 16.66%). Conclusions: This study underscores the importance of regularly updating local microbial profiles and understanding antimicrobial resistance patterns. Such updates are critical for informed decision-making in selecting optimal topical treatments for microbial keratitis.

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Clinical and microbiological profile of infective keratitis and their antibiotic sensitivity

Cited by 3 publications

References 2 publications

Microbiological profile of infective keratitis in a tertiary care hospital in north Karnataka

Microbiological profile of infective keratitis in a tertiary care hospital in north Karnataka

The Clinical and Microbiological Characteristics of Fungal Keratitis in COVID-19 Period

Microbial Spectrum of Keratitis at a Rural Tertiary Care Teaching Hospital

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