Clinical and Oncological Value of Preoperative BMI in Gastric Cancer Patients: A Single Center Experience

Voglino, Costantino; Mare, Giulio Di; Ferrara, Francesco; Franco, Lorenzo Giacinto De; Roviello, Franco; Marrelli, Daniele

doi:10.1155/2015/810134

Cited by 16 publications

(15 citation statements)

References 37 publications

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“…BMI was higher in P2 than in P1, and some studies report that BMI could be an independent factor for long-term survival after surgical treatment for gastric cancer (27,28). In our study, the average BMI difference between the two periods was only 0.5, and Voglino et al suggested that BMI does not affect postoperative complications or long-term survival (29).…”

Section: Discussioncontrasting

confidence: 43%

Long-term outcomes of gastric cancer in a single small center: a retrospective analysis

Kim

Seo

et al. 2020

Preprint

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Background The aim of this study is to evaluate the long-term outcomes and short-term outcomes of gastric cancer patients who underwent surgical treatment in a small-sized single center by one surgeon. Methods We retrospectively reviewed the medical records of 950 patients who underwent surgical treatment for gastric cancer between January 2000 and January 2010 at Dong-rae Paik Hospital, Inje University College of Medicine, Busan, Korea. A total of 820 patients were included and analyzed. We divided the time period into 2 groups: 2000–2005 (period 1) and 2006–2010 (period 2). Since all the surgeries were performed by one surgeon, we were able to analyze the changes in long-term outcomes as the individual surgeon volume accumulated. Results The mean follow-up period was 78.26 months. The overall survival and relapse-free survival rates of all patients were 84.6%, and 86.5%, respectively; the postoperative morbidity and mortality rates were 12% and 0.36%, respectively. The relapse-free survival rate was higher in period 2 than in period 1 (82.9% versus 90.2%, p = 0.002) Conclusions Our study showed that the short-term outcomes and long-term outcomes of gastric cancer treatment in a small-sized hospital were comparable to those in large-sized hospitals. Accumulated individual surgeon volume was related to a high relapse-free survival rate.

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Section: Discussioncontrasting

confidence: 43%

Long-term outcomes of gastric cancer in a single small center: a retrospective analysis

Kim

Seo

et al. 2020

Preprint

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“…A meta-analysis has demonstrated that high BMI was associated with increased risk of gastric cardia cancer [ 16 ]. The association between BMI and clinical outcomes of gastric cancer has also been widely investigated, however, it was still under debate [ 10 – 13 ]. Thus, the present study aims to investigate the impact of BMI on the clinical outcomes of gastric cancer after radical gastrectomy.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies reported that BMI was associated with postoperative complications [ 4 ] and prognosis [ 11 ] of gastric cancer. However, no association between BMI and clinical outcomes of gastric cancer has also been reported [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of body mass index on surgical outcomes of gastric cancer

et al. 2018

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BackgroundThe association between body mass index (BMI) and clinical outcomes of gastric cancer were still under debate. The aim of the present study was to investigate the impact of BMI on intraoperative conditions, postoperative complications and prognosis of gastric cancer.MethodsFrom October 2008 to March 2015, 1210 gastric cancer patients treated with D2 gastrectomy were enrolled in the present study. Patients were divided into three groups: low BMI group (BMI < 18.5 Kg/m2), normal BMI group (18.5 Kg/m2 ≤ BMI < 25.0 Kg/m2) and high BMI group (BMI ≥ 25.0 Kg/m2). Clinicopathological characteristics and prognosis of patients were recorded and analyzed. Propensity score matching was used to match patients in the three groups.ResultsThere were 107 patients in low BMI group (8.9%), 862 patients in normal BMI group (71.2%) and 241 patients in high BMI group (19.95%). Before matching, BMI was inversely associated with tumor size, tumor depth, lymph node metastasis (LNM) and tumor stage (all P < 0.05). After matching, the clinicopathological features were all comparable among the three groups (all P > 0.05). High BMI was associated with increased blood loss and operation time, and deceased number of retrieved lymph nodes (all P < 0.05). For postoperative complications, low BMI was associated with decreased rate of postoperative fever (P = 0.025). Age, BMI, tumor size, Borrmann type, pathological type, type of gastrectomy, tumor depth, LNM and tumor stage were risk factors for the prognosis of gastric cancer. Multivariate analysis showed that only BMI, tumor size, tumor depth and LNM were independent prognostic factors. The overall survival of patients with low BMI was significantly worse than patients with normal (P < 0.05) or high BMI (P < 0.05). However, the overall survival was comparable between patients with normal and high BMI (P > 0.05).ConclusionsBMI was inversely associated with tumor size, tumor depth, LNM and tumor stage. High BMI was associated with increased blood loss and operation time, and deceased number of retrieved lymph nodes. Low BMI was associated with decreased rate of postoperative fever and decreased survival.

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“…Gastric cancer (GC) represents one of the most frequent neoplasia worldwide, and specifically the fourth and fifth most common cancer in men and women and the third and fifth cause of cancer-related death [1].…”

Section: Introductionmentioning

confidence: 99%

Impact of reconstructive procedures with and without preserving the duodenal passage on body weight in patients after total gastrectomy for gastric cancer

et al. 2017

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Introduction/Objective The ideal reconstruction procedure after total gastrectomy should replace all lost functions of the stomach. The aim of this study was to evaluate the usefulness of preserving the duodenal passage in subsequent improvement of body weight (BW) and body mass index (BMI) in patients with gastric cancer after total gastrectomy. Methods A total of 30 patients with gastric cancer were prospectively randomly divided into a group of reconstruction with double-tract (n = 15) and a group of reconstruction with simple Roux-en-Y after total gastrectomy. They were stratified by sex, age, their anthropometric measurements (BW, BMI), primary tumor localization, Lauren's classification, TNM stage classification, length of hospital stay, operation duration, postoperative complications, and mortality. Postoperatively, BW and BMI were measured at three, six, and 12 months and compared between the two groups. Results The clinical group of double-tract patients had significantly higher the values of BW in the postoperative period after six (66.6 ± 4.9 vs. 61.7 ± 7.6; p < 0.05 paired Student's t-test) and after 12 months (67.0 ± 4.9 vs. 62.3 ± 7.2; p < 0.05 paired Student's t-test) compared to the group of Roux-en-Y patients. On the other hand, the clinical group of double-tract patients also had significantly higher the values of BMI in postoperative period after 12 months (23.6 ± 1.1 vs. 22.5 ± 1.6; p < 0.05 paired Student's t-test) in relation to the Roux-en-Y group of patients. Conclusion Reconstruction procedure carried out after total gastrectomy which implies preserving the duodenal passage has significant increase of BW and BMI, compared to reconstruction procedure without the preservation of the duodenal passage.

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Clinical and Oncological Value of Preoperative BMI in Gastric Cancer Patients: A Single Center Experience

Cited by 16 publications

References 37 publications

Long-term outcomes of gastric cancer in a single small center: a retrospective analysis

Long-term outcomes of gastric cancer in a single small center: a retrospective analysis

Impact of body mass index on surgical outcomes of gastric cancer

Impact of reconstructive procedures with and without preserving the duodenal passage on body weight in patients after total gastrectomy for gastric cancer

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