Clinical and parasitological assessment in mice treated with highly diluted Atropa belladonna

Sandri, Patrícia Flora; Portocarrero, Angela Rigo; Ciupa, Larissa; Veiga, Franciele Karina da; Falkowski, Gislaine Falkowski Sanchez; Benvenutti, Mateus Joacir; Rodrigues, Willian Nascimento de Souza; Aleixo, Denise Lessa; AraÃojo, Silvana Marques de

doi:10.51910/ijhdr.v13i47.734

Cited by 4 publications

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“…The patent mapping, obtained from the GTM analysis presented in Figure 5, consists of nodes with and without patents. Vacant technology identifies technology that is not patented, connecting non-patent nodes [100]. To determine the corresponding vacant technology, patents in the vicinity of the nodes must be analyzed [101].…”

Section: Identification Of Vacant Technology Through Generative Topog...mentioning

confidence: 99%

Patent Data Analytics for Technology Forecasting of the Railway Main Transformer

et al. 2022

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The railway main transformer is considered one of the most important electrical equipment for trains. Companies and research institutes around the world are striving to develop high-performance railway main transformers. In order to be the first mover for railway main transformer technology, companies and research institutes should predict vacant technology based on the analysis of promising detailed technology areas. Therefore, in this study, a patent analysis to predict vacant technologies based on identified promising IPC technology areas is provided. In order to identify promising detailed IPC technology areas, the technology mapping analysis, the time series analysis, and the social network analysis are conducted based on the patent-IPC matrix, extracted from the data information of 707 patents from the patent database of Korea, China, Japan, United States, Canada, and Europe. Then, through the GTM analysis based on promising detailed IPC technology areas, one vacant technology node and three analysis target nodes surrounding the vacant technology node are obtained to predict vacant technologies. From the analysis, we predict the following three groups of vacant technologies: (1) blowerless technology, (2) oil-free technology, and (3) solid-state technology. This study provides insights on the technology trend in railway main transformers, as well as the analysis framework for the development of R&D strategies based on the patent data.

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Section: Identification Of Vacant Technology Through Generative Topog...mentioning

confidence: 99%

Patent Data Analytics for Technology Forecasting of the Railway Main Transformer

et al. 2022

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In vivo evaluation of antipyretic effects of some homeopathic ultra-high dilutions on Baker's yeast-induced fever on Similia principle

Ahmad

Rehman

Abbasi

2018

Journal of Ayurveda and Integrative Medicine

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BackgroundHomeopathy is a controversial alternative system of medicine. The action of homeopathic medicines is considered slow and it is assumed that homeopathic medicines are ineffective in acute conditions such as fever.ObjectiveIn the present study, effects of 3 homeopathic medicines on baker's yeast induced fever were investigated.Materials and methods42 local strain rabbits were equally divided into 7 groups. Normal saline was orally administered to group 1 (normal control) rabbits without fever induction. Group 2 underwent baker's yeast-induced fever (negative control). Groups 3, 4, 5, 6 and 7 underwent baker's yeast-induced fever and were thereafter treated orally with paracetamol, Nux vomica 200C and 1M, Calcarea phos 200C and Belladonna 200C respectively. Rectal temperature was checked hourly. The abdominal writhing and frequency of loose stools were also monitored. ANOVA was applied for checking statistical significance. p ≤ 0.05 was considered significant.ResultsThe rectal temperature increased significantly (p < 0.05) in the negative control group when compared to the normal control. Abdominal writhing and loose stools monitoring showed increased writhing and loose stools frequency of group 2, 3, 6 and 7 rabbits. However, treatment of paracetamol significantly reduced rectal temperature. Group 4 & 5 showed significant reduction of rectal temperature together with abatement of abdominal writhing and loose stools.ConclusionN. vomica ultra-high dilutions have normalized rectal temperature and prevented the abdominal writhing and loose stools in baker's yeast-induced fever model of rabbits. It could be due to antidotal activity of N. vomica ultra-high dilutions. Therefore, N. vomica ultra-high dilutions can be useful antipyretic agents and can treat conditions associated with gastrointestinal symptoms. However, fixed conclusion can't be asserted due to caveat of small sample size.

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Evaluation of antipyretic activity of Belladonna and Pyrogenium ultrahigh dilutions in induced fever model

Ahmad

Abbasi

Rehman

2018

Journal of Complementary and Integrative Medicine

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Background Belladonna and Pyrogenium are commonly used to treat fever in homeopathy. But in vivo antipyretic activity of these medicines is not reported yet. The study was conducted to evaluate the effectiveness of ultrahigh dilutions of Belladonna (Bell) and Pyrogenium (Pyro) in fever model of rabbits induced by Baker's yeast. Methods Healthy, local strain rabbits (♂ and ♀) were divided into seven groups (n=42): Normal control, negative control, standard control, pyro 1000c, pyro 200c, Bell 1000c and Bell 200c. Fever was induced by intra peritoneal injection of 135 mg/kg Baker’s yeast suspension. Rectal temperature was measured hourly. All the medicines were administered once a day. The results were expressed as mean ± SEM. ANOVA and least significant difference post hoc test were applied for checking the level of significance, p-value of ≤0.05 was considered significant statistically. Results Pyro in both potencies significantly reduced fever in rabbits compared to negative control group, while both potencies of Bell were ineffective. Paracetamol and Pyro 1000c reduced by 1.2 °C (39.7 ± 0.1 to 38.5 ± 0.1), while Pyro 200c reduced by 1 °C temperature (39.7 ± 0.5 to 38.7 ± 0.2). Conclusions Pyro possesses marked antipyretic activity in rabbit’s Baker's yeast fever model. It would embolden its clinical use in fever with more guarantee of its efficacy. However, caveat of small sample size necessitates replication of experiment in large sample size.

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Clinical and parasitological assessment in mice treated with highly diluted Atropa belladonna

Cited by 4 publications

References 1 publication

Patent Data Analytics for Technology Forecasting of the Railway Main Transformer

Patent Data Analytics for Technology Forecasting of the Railway Main Transformer

In vivo evaluation of antipyretic effects of some homeopathic ultra-high dilutions on Baker's yeast-induced fever on Similia principle

Evaluation of antipyretic activity of Belladonna and Pyrogenium ultrahigh dilutions in induced fever model

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