Clinical and pathological analysis of renal biopsies of elderly patients in Northeast China: a single-center study

Abstract

Purpose: To identify the clinical characteristics, histopathological features, and prognosis of kidney disease in a large cohort of elderly patients from Northeast China. Methods: We retrospectively analyzed the renal disease spectrum in 7,122 patients who underwent renal biopsies at the Second Hospital of Jilin University from 2006 to 2020. Patients were grouped according to age: below 60 years (non-elderly group, n ¼ 5923) and at least 60 years (elderly group, n ¼ 1199). The clinical and pathological characteristics of renal biopsy patients in the groups were analyzed using the t-test and chi-square test. Results: Compared with the non-elderly group, the elderly group had significantly fewer patients with primary glomerulonephritis, but more patients with tubulointerstitial disorders (p < .05). The incidence of IgA nephropathy, mesangial proliferative glomerulonephritis, and lupus nephritis was significantly lower in elderly patients than in non-elderly patients. The incidence of membranous nephropathy, membranoproliferative glomerulonephritis, diabetic nephropathy, hypertensive nephropathy, systemic vasculitis-associated renal damage, and amyloid nephropathy was significantly higher in elderly patients than in non-elderly patients (p < .05). The incidence of perinephric hematoma (!4 cm 2 ) in elderly patients with renal biopsy was lower than that in non-elderly patients. We noted that 79.9% of primary glomerulonephritis patients who received immunosuppressive therapy showed a remission rate of 83.5%. Conclusion:The spectrum of kidney disease in the elderly is different from that in the younger population.

Role of kidney biopsy in diagnosis of different patterns of kidney diseases: A Single-Center Experience

“…The difference between both studies can be explained by the small number of patients included in our cohort compared with the previous study and the difference in ethnic populations between the two studies. DN and hypertensive nephrosclerosis were predominate in the older age group and this was consistence with previous studies (19,20) Our study has some limitations: First, it was of a small sample size which could have a drawback effect on the conclusion of the study. Second, because it was a single center study, the findings might not accurately reflect the prevalence of glomerular diseases at other centers.…”

“…In this study, we have found that the main indication for kidney biopsy was a nephrotic syndrome with abnormal renal function which was present in 30% of patients followed by patients with sub-nephrotic range proteinuria with abnormal renal function in 23% of cases while patients with nephrotic syndrome with normal kidney function were found in 23% of cases. In a previous report (19), the nephrotic syndrome was the most prevalent manifestation in patients who had a biopsy, followed by glomerulonephritis, CKD, and AKI. In our cohort, the most common pathological findings were FSGS in 25% followed by lupus nephritis in 19.6%.…”

Review on epidemiology, disease burden, and treatment patterns of IgA nephropathy in select APAC countries

“…Six publications provided evidence on IgAN incidence [ 30 , 61 , 63 , 74 , 77 , 78 ] in Australia ( n = 2), Japan ( n = 2), mainland China ( n = 1), and Taiwan ( n = 1). Most were cross-sectional observational studies ( n = 4), and sample sizes ranged from 156 [ 74 ] to 270,902 [ 63 ].…”

A rare form of systemic amyloidosis with kidney damage — AFIB-amyloidosis

“…по данным ряда исследований, она встречается приблизительной в 4,5% случаев всех биопсий и занимает 7-е место по частоте обнаружения [2]. при этом в возрасте старше 60 лет амилоидная нефропатия обнаруживает- ся в 3,5% случаев, тогда как в возрасте младше 60 лет -только в 0,5% случаев [3]. ещё реже встречается амилоидное поражение почек при амилоидозе других типов (нааа и неAL).…”