Clinical and physiological basis for a new method underlying rehabilitation of the damaged visual nerve function by direct electric stimulation

Bechtereva, N.P.; Shandurina, A.N.; Khilko, V.A.; Lyskov, Eugene; Matveev, Yu. K.; Panin, A.V.; Nikolsky, A.V.

doi:10.1016/0167-8760(85)90004-2

Cited by 15 publications

(5 citation statements)

References 15 publications

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“…Stimulation of the visual system in a non-invasive manner has been studied in Russia for several decades. Bechtereva et al (1985) applied electrical stimulation for invasive treatment of injured optic nerves and found significant vision recovery after 3-4 weeks. Our non-invasive ACS stimulation protocol builds on this prior experience.…”

Section: Discussionmentioning

confidence: 99%

Non-invasive alternating current stimulation improves vision in optic neuropathy

Sabel

Fedorov

Naue

et al. 2011

Restorative Neurology and Neuroscience

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Partial blindness after visual system damage is considered irreversible, yet the brain has residual visual capacities and considerable plasticity potential. We now applied non-invasive alternating current stimulation (ACS) to the visual system of patients with optic nerve damage with the aim to induce recovery of visual functions. Methods: In a prospective, double-blind, randomized, placebo-controlled clinical trial patients with several year old partial optic nerve lesions were treated with ACS (n = 12) or placebo-stimulation (n = 10). ACS was delivered transorbitally for 40 minutes on 10 days. Visual outcome measures and EEG were measured before and after treatment. Results: ACS, but not placebo, led to significant improvement of a visual field detection deficit by 69%, and also significantly improved temporal processing of visual stimuli, detection performance in static perimetry, and visual acuity. These changes were associated with alpha-band changes in the EEG power spectra. Visual improvements were stable for at least 2-months. Conclusions: ACS can induce vision restoration many years after optic neuropathy. Though the mechanism is still unclear, EEG changes indicate increased synchronization in posterior brain regions. The present study provides Class Ib evidence that non-invasive transorbital ACS is well tolerated and improves visual function in optic neuropathy.

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Section: Discussionmentioning

confidence: 99%

Non-invasive alternating current stimulation improves vision in optic neuropathy

Sabel

Fedorov

Naue

et al. 2011

Restorative Neurology and Neuroscience

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“…Another variant of ACS -transorbital alternating current -was used as a treatment for patients with vision loss (Bechtereva et al, 1985;Shandurina et al, 1996;Chibisova et al, 2001). But it was not until recently that systematic, randomized clinical studies were conducted showing therapeutic efficacy of noninvasive brain stimulation to restore (recover) vision in patients with visual system damage (Gall et al, 2011(Gall et al, , 2013Fedorov et al, 2011;Sabel et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Preclinical model of transcorneal alternating current stimulation in freely moving rats

Sergeeva

Henrich‐Noack

Gorkin

et al. 2015

RNN

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“…In conclusion, ES and MFS affect numerous cellular components, including (Gahl & Kunze, 2018) cell membrane; (Trevor‐Roper, 1951) mitochondria, which induces changes in inflammation and cell death; and (Bechtereva et al., 1985) the cell nucleus, which induces reprogramming and differentiation (Zablotskii et al., 2016b). Therefore, they can be used not only for diseases of the optic nerve but also for other ocular diseases, including corneal ulcers (Kanavi et al., 2016), orbital inflammation, and RPE disease (Gamboa et al., 2010).…”

Section: Discussionmentioning

confidence: 99%

“…The application of electric currents in ophthalmology dates back to 1950 (Trevor‐Roper, 1951), when low‐vision patients were stimulated by ES to detect phosphene (bright spots of light in the visual field). Pioneering studies by Bechtereva and colleagues in the early 1970s (Bechtereva et al., 1985) explored the effects of direct electrical current stimulation on the optic nerve, leading to improved visual fields in patients with low vision. Significant vision recovery was observed 3–4 weeks after invasive stimulation and persisted for over two years.…”

Section: Introductionmentioning

confidence: 99%

Application of electrostimulation and magnetic stimulation in patients with optic neuropathy: A mechanistic review

Khalili,

Shadmani,

Sanie‐Jahromi

2024

Developmental Neurobiology

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Visual impairment caused by optic neuropathies is irreversible because retinal ganglion cells (RGCs), the specialized neurons of the retina, do not have the capacity for self‐renewal and self‐repair. Blindness caused by optic nerve neuropathies causes extensive physical, financial, and social consequences in human societies. Recent studies on different animal models and humans have established effective strategies to prevent further RGC degeneration and replace the cells that have deteriorated. In this review, we discuss the application of electrical stimulation (ES) and magnetic field stimulation (MFS) in optic neuropathies, their mechanisms of action, their advantages, and limitations. ES and MFS can be applied effectively in the field of neuroregeneration.. Although stem cells are becoming a promising approach for regenerating RGCs, the inhibitory environment of the CNS and the long visual pathway from the optic nerve to the superior colliculus are critical barriers to overcome. Scientific evidence has shown that adjuvant treatments, such as the application of ES and MFS help direct thetransplanted RGCs to extend their axons and form new synapses in the central nervous system (CNS). In addition, these techniques improve CNS neuroplasticity and decrease the inhibitory effects of the CNS. Possible mechanisms mediating the effects of electrical current on biological tissues include the release of anti‐inflammatory cytokines, improvement of microcirculation, stimulation of cell metabolism, and modification of stem cell function. ES and MFS have the potential to promote angiogenesis, direct axon growth toward the intended target, and enhance appropriate synaptogenesis in optic nerve regeneration.

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Clinical and physiological basis for a new method underlying rehabilitation of the damaged visual nerve function by direct electric stimulation

Cited by 15 publications

References 15 publications

Non-invasive alternating current stimulation improves vision in optic neuropathy

Non-invasive alternating current stimulation improves vision in optic neuropathy

Preclinical model of transcorneal alternating current stimulation in freely moving rats

Application of electrostimulation and magnetic stimulation in patients with optic neuropathy: A mechanistic review

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