Clinical and phytochemical studies of Plantago major in pressure ulcer treatment: A randomized controlled trial

Ghiasian, Masoud; Niroomandi, Zahra; Dastan, Dara; Poorolajal, Jalal; Zare, Fateme; Ataei, Sara

doi:10.1016/j.ctcp.2021.101325

Cited by 9 publications

(20 citation statements)

References 12 publications

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“…In the clinical trial carried out by Ghiansian et al, 16 the authors observed that the group treated with P major experienced better recovery compared with the control group ( P < .05). According to previous studies with P major , its effect on wound healing can be attributed to its antioxidant, anti-inflammatory, antimicrobial, and tissue-repairing effects 45,46 …”

Section: Discussionmentioning

confidence: 94%

Topical Intervention of Natural Products Applied in Patients with Pressure Injuries: A Scoping Review

Ouchi

Pereira

Okuyama

2023

Adv Skin Wound Care

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OBJECTIVEPressure injuries (PIs) represent a major medical and nursing problem in individuals with decreased or limited mobility. This scoping review aimed to map the controlled clinical trials with topical interventions of natural products applied to patients with PIs and to verify the existence of phytochemical similarities among these products.DATA SOURCESThis scoping review was developed according to the JBI Manual for Evidence Synthesis. Controlled trials were searched in the following electronic databases from their inceptions until February 1, 2022: Cochrane Central Register of Controlled Trials, EMBASE, PubMed, SciELO, Science Direct, and Google Scholar.STUDY SELECTIONStudies involving individuals with PIs, individuals treated with topical natural products compared to a control treatment, and outcomes with wound healing or wound reduction were included in this review.DATA EXTRACTIONThe search identified 1,268 records. Only six studies were included in this scoping review. Data were independently extracted using a template instrument from the JBI.DATA SYNTHESISThe authors summarized the characteristics of the six included articles, synthesized outcomes, and compared similar articles. Honey and Plantago major dressings were the topical interventions that significantly reduced wound size. The literature suggests that the effect on wound healing of these natural products may be related to the presence of phenolic compounds.CONCLUSIONSThe studies included in this review show that natural products can positively impact the healing of PIs. However, there are limited controlled clinical trials addressing natural products and PIs in the literature.

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Section: Discussionmentioning

confidence: 94%

Topical Intervention of Natural Products Applied in Patients with Pressure Injuries: A Scoping Review

Ouchi

Pereira

Okuyama

2023

Adv Skin Wound Care

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“…The prepared extract was re-filtered through a high-purity filter paper and then dried using a rotary evaporator under a vacuum at 45EC. The obtained extract was stored at -40EC for further experiments 11 .…”

Section: Methodsmentioning

confidence: 99%

“…In traditional medicine, this plant has been extensively administered in a number of diseases related to skin, circulation, reproduction, respiratory organs, digestive organs, infections and tumors [7][8][9] . Interestingly enough, it has been suggested that P. major exerts its wound healing effect through different mechanisms including antioxidant, antiinflammatory and antimicrobial functions and stimulation of fibroblast proliferation [10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

Healing Effect of Plantago major and Photodynamic Therapy Combination on Skin Wounds

Rahim¹,

Masseh²,

Salih³

et al. 2023

International J. of Pharmacology

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Background and objective: Current strategies to address wound care include both traditional and modern options. Medicinal plants, as a part of traditional medicine and photodynamic therapy, as a modern option, have shown promising effects in wound care and repair.In this study, a combination of Plantago major and laser therapy might have more effective wound healing effects was hypothesized. Materials and Methods: To examine this, P. major extract was prepared through the maceration method. Human fibroblasts were harvested in FBS and antibiotic-contained DMEM. Upon reaching 70-80% confluency, cells were seeded in a 96-well plate and then treated with P. major (different concentrations), laser (980 nm) and P. major-laser combination. To determine the cell viability percentage, an MTT assay was performed. A scratch assay to investigate HFFF2 migration after treatment with P. major, laser and their combination was also carried out. The expression of IL-6 and TNF-" as pro-inflammatory cytokines and VEGF as a growth factor were analyzed using a real-time PCR technique. Results: Current findings showed that 160 µg mLG 1 P. major as well as the combination of 160 µg mLG 1 P. major and laser posed no cytotoxicity to HFFF2 cells. Scratch assay results indicated that the P. major and laser combination could effectively increase HFFF2 migration ability as compared to control cells. An upregulated VEGF, IL-6 and TNF-" gene expression in cells treated with the combined P. major and laser was also found. Conclusion: The evidence from this study suggested that the combination of traditional and modern wound repair approaches could result in more favorable outcomes.

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“…Extracts of leaves, stems, and roots have long been used as a treatment for kidney stones, antifungal, bladder, antioxidant, gastrointestinal infections, diabetes, and anticancer (Kartini & Azminah, 2012;Hossain & Ismail, 2016). Several studies have proven that Plantago major, Sonchus arvensis, Strobilanthes crispus, and Orthosiphon stamineus have nephrolithiasis effects (Singh et al, 2009;Alkreathy et al, 2014;Chun et al, 2020;Ghiasian et al, 2021). Jimoh et al (2021) proved that luteolin, quercetin, apigenin, and sinensetin compounds play a role in controlling the crystallization process of kidney stones (jimoh et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…The research that has been carried out is limited to determining marker compounds in single herbal plants and has not been applied to the formulation of herbal medicinal preparations using the TLC-Densitometry method (Abdullah et al, 2012;Hossain & Ismail, 2016;Kuppusamy et al, 2017). Several analytical methods for determining luteolin, quercetin, apigenin, and sinensetin have been developed using the HPLC method (Kuppusamy et al, 2017;Grek et al, 2019;Ghiasian et al, 2021). however, this instrument is expensive and require expertise specialized in instrument operation.…”

Section: Introductionmentioning

confidence: 99%

Optimization Method and Stability Test to Determinate Luteolin, Quercetin, Apigenin, and Sinensetin Levels in Herbal Medicines Using TLC-Densitometry

Hidayatullah

Yuwono

Primaharinastiti

2022

JFIKI

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Background: Nephrolithiasis is a condition in which there are one or more kidney stones in the pelvis or calyces. Luteolin, quercetin, apigenin, and sinensetin are marker compounds in the extracts of Plantago major, Sonchus arvensis, Strobilanthes crispus and Orthosiphon stamineus which have nephrolithiasis activity. To control the quality of herbal medicines, a TLC-Densitometry method was developed in this study using luteolin, quercetin, apigenin, and sinensetin as phytochemical markers. Objective: The present work aimed to develop optimal conditions for analyzing luteolin, quercetin, apigenin, and sinensetin. Methods: Determination of optimal conditions for analysis is carried out by determining the composition of the mobile phase, chamber saturation time, and analysis wavelength. Silica gel 60 F254 was used as the stationary phase. Stability tests were carried out by analyzing standards and samples at 0, 4, 8, and 24 hours. Results: The best separation that produces symmetrical peaks of herbal medicine was achieved under isocratic conditions using the composition of the mobile phase chloroform : acetone: dichloromethane : acetonitrile : formic acid (6 : 2: 2 : 0,05 : 0.05 v/v/v/v/ v) with a wavelength of 335 nm with a saturation time of 30 minutes. Conclusion: In this study, the optimal conditions for the analysis of luteolin, quercetin, apigenin, and sinensetin. Luteolin, quercetin, apigenin, and sinensetin are unstable during 8 hours of storage. Therefore, standard solutions and samples must be made fresh to maintain stability.

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Clinical and phytochemical studies of Plantago major in pressure ulcer treatment: A randomized controlled trial

Cited by 9 publications

References 12 publications

Topical Intervention of Natural Products Applied in Patients with Pressure Injuries: A Scoping Review

Topical Intervention of Natural Products Applied in Patients with Pressure Injuries: A Scoping Review

Healing Effect of Plantago major and Photodynamic Therapy Combination on Skin Wounds

Optimization Method and Stability Test to Determinate Luteolin, Quercetin, Apigenin, and Sinensetin Levels in Herbal Medicines Using TLC-Densitometry

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