Clinical and prognostic relevancy of left ventricular trabeculation assessed by cardiac magnetic resonance in patients with dilated cardiomyopathy

Mazurkiewicz, Łukasz; Petryka, Joanna; Śpiewak, Mateusz; Miłosz-Wieczorek, Barbara; Małek, Łukasz A.; Jasińska, Anna; Jarmus, Ewelina; Marczak, Magdalena; Miśko, Jolanta; Grzybowski, Jacek

doi:10.5603/kp.a2017.0097

Cited by 12 publications

(6 citation statements)

References 27 publications

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“…In our study, LGE was noted in 25% of patients with LVNC, which is similar to data reported by Cheng et al and Nucifora et al, who demonstrated the same prevalence of LGE in their cohorts [19,20]. The percentage of adults with LVNC in whom LGE is recorded varies; however, typically it is more commonly observed and the reported prevalence ranges between 13 and 55% [17,[45][46][47][48][49]. The distribution of LGE is diverse-in the majority of patients it is mid-myocardial; however, subendocardial, subepicardial, and transmural LGE is also described.…”

Section: Fibrosis In Pediatric Lvncsupporting

confidence: 90%

Left and Right Ventricular Morphology, Function and Myocardial Deformation in Children with Left Ventricular Non-Compaction Cardiomyopathy: A Case-Control Cardiovascular Magnetic Resonance Study

Sarnecki

Paszkowska

Petryka-Mazurkiewicz

et al. 2022

JCM

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Background: Left ventricular non-compaction (LVNC) is a rare cardiomyopathy typically involving the left ventricle (LV); however, the right ventricle (RV) can also be affected. This case-control study aimed to assess the morphology and function of LV and RV in children with LVNC. Methods: Sixteen children (13 ± 3 years, six girls) with LVNC were compared with 16 sex- and age-matched controls. LV and RV morphology and function were evaluated in cardiovascular magnetic resonance (CMR) studies. Additionally, LV and RV global radial (GRS), circumferential (GCS), and longitudinal strain (GLS) were assessed using tissue-tracking analysis. Results: Patients with LVNC did not differ from the healthy controls in terms of age, height, weight, and body surface area (BSA). In total, 4/16 subjects with LVNC had mid-wall late gadolinium enhancement (LGE). Compared to the control group, patients with LVNC had higher end-diastolic volume (EDV) indexed for body surface area (BSA), lower ejection fraction (EF), and lower LV strain parameters (all p < 0.05). Children with LVNC also presented with thicker RV apical trabeculation, whereas there were no differences in RV EF and EDV/BSA between the groups. Nevertheless, children with LVNC had impaired RV GRS and GCS (both p < 0.05). Conclusions: LVNC in pediatric patients is associated with LV enlargement and impaired LV systolic function. Additionally, children with LVNC have increased RV trabeculations and subclinical impairment of RV myocardial deformation.

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Section: Fibrosis In Pediatric Lvncsupporting

confidence: 90%

Left and Right Ventricular Morphology, Function and Myocardial Deformation in Children with Left Ventricular Non-Compaction Cardiomyopathy: A Case-Control Cardiovascular Magnetic Resonance Study

Sarnecki

Paszkowska

Petryka-Mazurkiewicz

et al. 2022

JCM

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“…We calculated the hazard ratios of the noncompaction degree for MACE in the patients who met the Peterson criteria ( n = 133), and came to a consistent result: there was no significant correlation between the degree of noncompaction and the incidence of MACE. However, other previous studies showed that the NC/C ratio, segments, and mass of noncompaction were independent predictors of LV systolic dysfunction 22,23 . Therefore, the effect of the degree of noncompaction on prognosis needs further investigation.…”

Section: Discussionmentioning

confidence: 88%

Prognosis and subtype analysis of left ventricular noncompaction in adults: A retrospective multicenter study

Feng

Ning

Zhang

et al. 2023

Clinical Cardiology

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Background: Left ventricular noncompaction (LVNC) is a heterogeneous myocardial disorder with an uncertain prognosis. There was a lack of studies on LVNC subtypes at present. This study sought to identify the prognosis of the overall population of LVNC and to describe the distribution of different subtypes and compare their prognosis.Hypothesis: Patients with different subtypes of LVNC may have different prognoses.Methods: Patients who fulfilled the Jenni criteria and/or Petersen criteria were included. Major adverse cardiovascular events (MACE) were defined as a combination of heart failure (HF) hospitalization and all-cause mortality.Results: A total of 200 patients from four hospitals were included. The mean age at diagnosis was 48.2 years, and 61.5% of the patients were male. Left ventricular ejection fraction (LVEF) < 50% was present in 54% of the patients. Over a mean retrospective time period of 22.2 months, 47 (23.5%) patients experienced MACE.Age (hazard ratio [HR] 1.03; 95% confidence interval [CI] 1.01-1.06; p = .004), LVEF < 50% (HR 2.32; 95% CI 1.09-4.91; p = .028) and ventricular tachycardia/ ventricular fibrillation (HR 2.17; 95% CI 1.08-4.37; p = .03) were significantly associated with the risk of MACE. The most common subtype was dilated LVNC (51.3%), followed by benign LVNC (21.3%) and LVNC with arrhythmias (10.5%).Patients with dilated LVNC had significantly increased cumulative incidence of MACE, HF hospitalization, and all-cause mortality (p < .05).Conclusions: Age, LVEF < 50%, and ventricular tachycardia/ventricular fibrillation were independent risk factors for prognosis of LVNC. The most common subtype was dilated LVNC, which had a worse prognosis.

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“…Обна-ружение отсроченного накопления гадолиния и его клиническое значение было ранее изучено в качестве предиктора будущих сердечных событий у пациентов с дилатационной кардиомиопатией [13][14][15]. В 2018 г. были опубликованы результаты мета-анализа С. Grigoratos, включавшим в себя 4 исследования [16][17][18][19]. У пациентов с НКЛЖ, включенных в данный мета-анализ [20], отсроченное накопление гадолиния в миокарде ассоциировалось с прогностически неблагоприятным течением заболевания и являлось предиктором серьезных неблагоприятных сердечно-сосудистых событий, таких как сердечная смерть, ишемический инсульт, фибрилляция желудочков, госпитализация по поводу сердечной недостаточности.…”

Section: Discussionunclassified

New Variant of <i>MYH7</i> Gene Nucleotide Sequence in Familial Non-Compaction Cardiomyopathy with Benign Course

Myasnikov¹,

Куликова²,

Мешков³

et al. 2020

Racionalʹnaâ farmakoterapiâ v kardiologii

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Некомпактная кардиомиопатия левого желудочка (НКЛЖ) -генетически детерминированная кардиомиопатия, для которой характерны различные варианты клинического течения. Семейные случаи НКЛЖ позволяют более детально изучить роль генетических факторов в патогенезе и прогнозе кардиомиопатии, а также определить особенности клинического течения. Цель. Продемонстрировать случай семейной формы некомпактной кардиомиопатии со стабильным течением заболевания и оценить возможную связь найденной мутации с прогнозом заболевания. Материал и методы. В исследование была включена семья с НКЛЖ. Пробанду с некомпактной кардиомиопатией и его родственникам 1 и 2 степени родства было проведено клинико-инструментальное обследование и экзомное секвенирование. НКЛЖ был диагностирован у пробанда и у отца пробанда. Диагноз НКЛЖ был установлен на основании эхокардиографических критериев и подтвержден при проведении магнитно-резонансной томографии (МРТ). Результаты. В данной статье представлены результаты комплексного клинико-инструментального обследования семьи с НКЛЖ с выявленным новым вариантом в гене MYH7, отсутствием интрамиокардиального фиброза по данным МРТ сердца и благоприятным течением заболевания, как у отца пробанда, так и у самого пробанда. Проведен сравнительный анализ полученных данных с результатами последних крупных исследований и мета-анализов, посвященных изучению прогностических факторов у пациентов с НКЛЖ, с выявленными вариантами в гене MYH7. Заключение. Выявленный в гене MYH7 вариант p.His1338Pro может иметь отношение к развитию НКЛЖ с доброкачественным течением.

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Clinical and prognostic relevancy of left ventricular trabeculation assessed by cardiac magnetic resonance in patients with dilated cardiomyopathy

Cited by 12 publications

References 27 publications

Left and Right Ventricular Morphology, Function and Myocardial Deformation in Children with Left Ventricular Non-Compaction Cardiomyopathy: A Case-Control Cardiovascular Magnetic Resonance Study

Left and Right Ventricular Morphology, Function and Myocardial Deformation in Children with Left Ventricular Non-Compaction Cardiomyopathy: A Case-Control Cardiovascular Magnetic Resonance Study

Prognosis and subtype analysis of left ventricular noncompaction in adults: A retrospective multicenter study

New Variant of <i>MYH7</i> Gene Nucleotide Sequence in Familial Non-Compaction Cardiomyopathy with Benign Course

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