Clinical and Research Solutions to Manage Obstructive Sleep Apnea: A Review

Xia, Fen

doi:10.3390/s21051784

Cited by 27 publications

(23 citation statements)

References 125 publications

(148 reference statements)

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“…This obstruction is a life-threatening disease that needs consistent assessment and either non-invasive or different invasive intervention methods [ 19 ]. Among a series of methods to treat upper airway obstruction, electrical stimulation shows a potential high-performance solution [ 20 ]. The principle of an electrical stimulation system is to treat upper airway obstruction since the genioglossal muscle can be contracted when stimulating the hypoglossal nerve.…”

Section: Proposed System Modulesmentioning

confidence: 99%

A Closed-Loop Approach to Fight Coronavirus: Early Detection and Subsequent Treatment

et al. 2022

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The recent COVID-19 pandemic has caused tremendous damage to the social economy and people’s health. Some major issues fighting COVID-19 include early and accurate diagnosis and the shortage of ventilator machines for critical patients. In this manuscript, we describe a novel solution to deal with COVID-19: portable biosensing and wearable photoacoustic imaging for early and accurate diagnosis of infection and magnetic neuromodulation or minimally invasive electrical stimulation to replace traditional ventilation. The solution is a closed-loop system in that the three modules are integrated together and form a loop to cover all-phase strategies for fighting COVID-19. The proposed technique can guarantee ubiquitous and onsite detection, and an electrical hypoglossal stimulator can be more effective in helping severe patients and reducing complications caused by ventilators.

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Section: Proposed System Modulesmentioning

confidence: 99%

A Closed-Loop Approach to Fight Coronavirus: Early Detection and Subsequent Treatment

et al. 2022

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“…This obstruction is a life-threatening disease which needs consistent assessment and either non-invasive or different invasive intervention methods [14]. Among series of methods to treat upper airway obstruction, electrical stimulation show potential high-performance solution [15]. The principle of electrical stimulation system to treat upper airway obstruction since the genioglossal muscle can be contracted when stimulating the hypoglossal nerve.…”

Section: Respiration Monitoring and Electrical/magnetic Stimulationmentioning

confidence: 99%

A Closed-loop Approach to Fight Coronavirus: Early Detection and Subsequent Treatment

Rong¹,

Zheng²,

Yang³

et al. 2022

Preprint

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The recent COVID-19 pandemic has caused tremendous damage to social economy and people’s health. Some major issues fighting COVID-19 include early and accurate diagnosis and the shortage of ventilator machines for critical patients. In this work, we propose a closed-loop solution to deal with COVID-19: portable biosensing and wearable photoacoustic imaging for early and accurate diagnosis of infection and magnetically neuromodulation or minimally invasive electrical stimulation to replace the traditional ventilation. Proposed technique can guarantee ubiquitous and onsite detection, and electrical hypoglossal stimulator can be more effective in helping severe patients as well as reducing complications caused by ventilators.

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“…In 2016, the first case of HNS for OSA in adolescents with DS was reported ( 15 ). Although most research in recent years have shown that HNS is a better option, these studies have limitations in terms of sample size, in follow-up duration, and in documentation of complications ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

Hypoglossal nerve stimulation in adolescents with down syndrome and obstructive sleep apnea: A systematic review and meta-analysis

et al. 2022

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ObjectiveTo evaluate the efficacy and adverse effects of hypoglossal nerve stimulation in adolescents with down syndrome and obstructive sleep apnea.MethodsA systematic search was conducted using PubMed, Web of Science, Embase, and Scopus databases. The systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A comprehensive search strategy used a combination of Medical Subject Headings and free words with “OR” and “AND.” Articles were screened to extract data reporting apnea-hypopnea index, quality of life, voltage, follow-up duration, and complications. All included participants were adolescents with down syndrome and obstructive sleep apnea.ResultsA total of 92 articles were identified, of which 9 articles met the inclusion criteria. A total of 106 patients were included. All the studies showed that patients receiving hypoglossal nerve stimulation experienced a significant decrease in apnea-hypopnea index (at least 50%). The pooled AHI was significantly lower in patients following treatment (mean AHI reduction 17.43 events/h, 95% confidence interval 13.98–20.88 events/h, P < 0.001) after 2 case reports were excluded. The pooled OSA-18 were significantly decreased in 88 patients after treatment (mean OSA-18 reduction 1.67, 95% confidence interval 1.27–2.08, P < 0.001) after excluding 5 studies. Four investigations examined the necessity to optimize stimulation voltage for arousal during treatment. The most common complication was pain or discomfort in the tongue or mouth. Most studies had relatively short patient follow-up periods, with the most extended follow-up being 44–58 months.ConclusionHypoglossal nerve stimulation significantly reduces apnea-hypopnea index and improves the quality of life; and thus, could be a potential alternative therapy for obstructive sleep apnea in adolescents with down syndrome. The adolescent's age, potential complications, adverse events, long-term efficacy, and comfort, needs to be considered while performing hypoglossal nerve stimulation.

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Clinical and Research Solutions to Manage Obstructive Sleep Apnea: A Review

Cited by 27 publications

References 125 publications

A Closed-Loop Approach to Fight Coronavirus: Early Detection and Subsequent Treatment

A Closed-Loop Approach to Fight Coronavirus: Early Detection and Subsequent Treatment

A Closed-loop Approach to Fight Coronavirus: Early Detection and Subsequent Treatment

Hypoglossal nerve stimulation in adolescents with down syndrome and obstructive sleep apnea: A systematic review and meta-analysis

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