Clinical and sexual risk correlates of<i>Mycoplasma genitalium</i>in urban pregnant and non-pregnant young women: cross-sectional outcomes using the baseline data from the Women’s BioHealth Study

Mycoplasma genitalium is a fastidious organism of the class Mollicutes, the smallest prokaryote capable of independent replication. First isolated in 1981, much is still unknown regarding its natural history in untreated infection. It is recognized as a sexually transmitted pathogen causing acute and chronic non-gonococcal urethritis (NGU) in men, with a growing body of evidence to suggest it also causes cervicitis and pelvic inflammatory disease in women. Its role in several other clinical syndromes is uncertain. The majority of people infected remain asymptomatic and clear infection without developing disease; asymptomatic screening is therefore not recommended. Prevalence rates are higher in patients attending sexual health clinics and in men with NGU. Limited availability of diagnostics has encouraged syndromic management, resulting in widespread antimicrobial resistance and given that few antimicrobial classes have activity against M. genitalium , there is significant concern regarding the emergence of untreatable strains. There is a need for wider availability of testing, which should include detection of macrolide resistance mediating mutations. Expertise in interpretation of microbiological results with clinical correlation ensures targeted treatment avoiding unnecessary antibiotic exposure. Public health surveillance nationally and internationally is vital in monitoring and responding to changing epidemiology trends. In this review, we summarize current knowledge of M. genitalium , including epidemiology, clinical and microbiological data, and discuss treatment challenges in the era of rising multidrug resistance.

show abstract

“…This suggests that high-risk sexual behaviour increases risk of acquisition of M. genitalium along with other STIs [16, 17].…”

Section: Risk Factors For Infectionmentioning

confidence: 99%

Mycoplasma genitalium: A Review

Gnanadurai

Fifer

2020

Microbiology

View full text Add to dashboard Cite

show abstract

“…These findings underscore the need for ongoing investigation of the predictors of MG infection and the development of additional tools to predict specific STIs. Clinical correlates of MG infection and the impact on vaginal microbiota are a topic of ongoing investigation, 23 but as shown here and in other studies, MG infection is a prevalent STI. 2,5,9 The cornerstone of STI prevention is diagnosis and treatment, and this study demonstrates that the use of an age-modified risk quiz may be useful for assessing the need for STI screening, including testing for MG.…”

Section: Discussionmentioning

confidence: 58%

“…Pregnant and non-pregnant female patients seeking routine gynecological or prenatal health services in outpatient AYA and Obstetrics and Gynecology clinics within a large, urban academic medical center in the mid-Atlantic United States were recruited for participation in the Women’s BioHealth study. 23 Patients aged 13 to 29 years were eligible to participate if they were having testing for CT and GC. 23 The Women’s BioHealth Study is a large longitudinal cohort study to determine the prevalence, clinical correlates, and outcomes of MG and TV in urban pregnant and non-pregnant females.…”

Section: Methodsmentioning

confidence: 99%

“…23 Patients aged 13 to 29 years were eligible to participate if they were having testing for CT and GC. 23 The Women’s BioHealth Study is a large longitudinal cohort study to determine the prevalence, clinical correlates, and outcomes of MG and TV in urban pregnant and non-pregnant females. 23 Non-English-speaking individuals and persons with cognitive or language impairments that prevented completion of informed consent procedures and the behavioral risk questions were excluded from the study.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Does the Sex Risk Quiz Predict Mycoplasma genitalium Infection in Urban Adolescents and Young Adult Women?

Ronda¹,

Gaydos²,

Perin³

et al. 2018

Sexual Trans Dis

Self Cite

View full text Add to dashboard Cite

show abstract

“…1,3 M. genitalium infection has been reported to be associated with other STIs specifically Chlamydia trachomatis . 4 The prevalence of M. genitalium infection is reported to be higher among people living with HIV (LWHIV) than in the general population. 5,6 However, the interplay of M. genitalium and HIV co-infection is poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Low prevalence of macrolide resistance in Mycoplasma genitalium infections in a cohort of pregnant women living with human immunodeficiency virus

et al. 2022

View full text Add to dashboard Cite

Objective Macrolide resistance in Mycoplasma genitalium ( M. genitalium) is increasing as a result of the widespread use of azithromycin in the treatment of sexually transmitted infections (STIs). To date, there are few published studies on macrolide resistance patterns in South African pregnant women. This study now contributes to the growing body of knowledge. Methods This study included 385 pregnant women living with HIV. Vaginal swabs were collected from consenting pregnant women and used for the detection of M. genitalium using the TaqMan assay . Macrolide resistance-associated mutations in the 23S rRNA gene were determined for all samples that tested positive for M. genitalium using the AllplexTM MG & AziR assay (Seegene) which allows for the simultaneous detection and identification of M. genitalium and six mutations ( A2058C, A2058G, A2058T, A2059C, A2059G and A2059T) responsible for azithromycin resistance. The correlation between the TaqMan assay and AllplexTM MG & AziR assay (Seegene) for the detection of M. genitalium was also performed in a subset of 121 samples. Results Of the 385 samples tested in this study, 14 samples were positive for M. genitalium estimating a prevalence of 3.6%. The same 14 samples also tested positive on the AllplexTM assay indicating a good correlation between the TaqMan Assay and the AllplexTM. Of the 14 positive samples, one sample carried a mutation at position A2059G denoting macrolide resistance in this pathogen. Mutations in the other regions of the 23S rRNA were not detected. All assay controls used in the mutation scanning produced the desired results showing the validity of the assay. Conclusion In this study, macrolide resistance in M. genitalium was detected. Despite the low prevalence of resistance determinants ongoing antimicrobial resistance surveillance is vital considering that azithromycin is used in the syndromic management for the treatment of vaginal discharge syndrome.

show abstract

Clinical and sexual risk correlates ofMycoplasma genitaliumin urban pregnant and non-pregnant young women: cross-sectional outcomes using the baseline data from the Women’s BioHealth Study

Abstract: MG infection was common, associated with STI co-infection and often asymptomatic, and pregnancy status did not confer protection.

Cited by 19 publications

References 13 publications

Mycoplasma genitalium: A Review

Mycoplasma genitalium: A Review

Does the Sex Risk Quiz Predict Mycoplasma genitalium Infection in Urban Adolescents and Young Adult Women?

Low prevalence of macrolide resistance in Mycoplasma genitalium infections in a cohort of pregnant women living with human immunodeficiency virus

Contact Info

Product

Resources

About