Clinical and Social Aspects of Marihuana Intoxication

Wikler, Abraham

doi:10.1001/archpsyc.1970.01750040032005

Cited by 16 publications

(2 citation statements)

References 12 publications

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“…is the better prognosticator of consequences for his health and for the health of others in his social milieu [33]. In the study described above, responding was well maintained by the stimuli associated with the injection, even when cocaine injections were no longer scheduled.…”

Section: Figurementioning

confidence: 91%

Preclinical assessment of abuse liability of drugs

Katz¹,

Goldberg²

1988

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Studies that are used in preclinical assessment of the liability of a drug to become an abuse problem are reviewed. These studies examine the capacity of a drug to produce physiological dependence or to function as a reinforcer. Studies that examine physiological dependence by assessing whether a drug reverses signs of withdrawal from a standard drug are rapid, reliable and inexpensive methods for determining if a drug produces dependence of a type similar to the standard. However, these techniques will not determine if the drug produces a unique type of dependence. Studies that examine whether a drug functions as a reinforcer have been predictive of whether a drug will be abused in human populations. Attempts to rank order drugs with respect to their efficacy as reinforcers, however, are not predictive of measures of extent of abuse in human populations. Since abuse of drugs in human populations is a function of societal variables in addition to pharmacological factors, it is unlikely that preclinical assessments will ever yield more than qualitative information on abuse liability of drugs.

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Section: Figurementioning

confidence: 91%

Preclinical assessment of abuse liability of drugs

Katz¹,

Goldberg²

1988

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“…Many workers have demonstrated that novices react more adversely to the use of cannabis than the habitual usersindicating that ability to contain and enjoy the effects of cannabis is probably a learnt behaviour. Setting, as well as the mental set, has an important influence on the effects of cannabis use (Wikler 1970, Waskow et al 1970). In isolation and in austere setting the effect of cannabis is more sedative than euphoric.…”

Section: Factors Affecting Human Responsementioning

confidence: 99%