Clinical applicability of the <scp>T</scp>hy3a cytological category in thyroid nodules aspirates. Our experience in one hundred and fifty‐seven patients with <scp>T</scp>hy3 cytology

Wong, Gentle; Awad, Zaid; Wong, Phui Yee; Wood, Stephen L.; Farrell, Roy

doi:10.1111/coa.12307

Cited by 5 publications

(3 citation statements)

References 7 publications

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“…Alexander [11], Mihai [12], Tysome [13], Dutta [14], Lakhani [15], Pagni [16], Wong [17], Rago [18], Brophy [19], Trombetta [20], Giusti [21], Khalil [22]. Finally, 13 articles; Agrawal [23], Dallari [24], Deandrea [25], Doddi [26], Fadda [27], Gill [28], Glynn [29], Kelly [30], Lobo [31], Mehanna [32], Montgomery [33], Mullen [34] and Parkinson [35] were included in the present systematic review and meta-analysis.…”

Section: Qualitative Analysis (Systematic Review)mentioning

confidence: 99%

Risk of malignancy in the various categories of the UK Royal College of Pathologists Thy terminology for thyroid FNA cytology: A systematic review and meta‐analysis

Poller

Bongiovanni

Trimboli³

2019

Cancer Cytopathology

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Background. The UK Royal College of Pathologists Thy terminology for reporting thyroid FNAC cytology was first published in 2009, used throughout the United Kingdom and Ireland, in some parts of Italy and Switzerland, and elsewhere. There is no review of the literature or meta-analysis of the risk of malignancy (ROM) in the various categories of the UK Thy terminology. The study goal was to establish the published ROM for each Thy category and compare results with other existing terminology systems where similar meta-analyses were available. Methods. A comprehensive literature search of online databases was conducted in May 2019 examining the ROM for histologically proven nodules with preoperative FNAC classified according to the UK Thy terminology. Results. 25 articles were identified showing results of both cytology and histology. 12 of these were excluded to prevent selection bias as they showed data in just one Thy category. In the remaining 13 articles the pooled ROM was as follows;

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Section: Qualitative Analysis (Systematic Review)mentioning

confidence: 99%

Risk of malignancy in the various categories of the UK Royal College of Pathologists Thy terminology for thyroid FNA cytology: A systematic review and meta‐analysis

Poller

Bongiovanni

Trimboli³

2019

Cancer Cytopathology

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“…Prior to this, all encapsulated follicular pattern tumours with nuclear features of papillary thyroid cancer (PTC) were classified as malignant irrespective of their invasive potential [ 8 ]. The new category aimed to reduce the overtreatment of such nodules by removing the term carcinoma [ 9 ]. However, these nodules are not truly benign, with the WHO classifying NIFTP as ‘unspecified, borderline or uncertain behaviour’ [ 7 ].…”

Section: Methodsmentioning

confidence: 99%

Have We Got Thy3 Wrong in the UK? A Four-Year Single-Site Analysis of Malignancy Rates in Thy3 Nodules

Chandrasekar¹,

Jayaram²,

Carpentier³

2021

Cureus

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Introduction Thyroid nodules routinely undergo ultrasound-guided fine-needle aspiration (FNA), as recommended by the National Institute for Health and Care Excellence (NICE) and the British Thyroid Association (BTA). The cytology results are classified using the “Thy” system from Thy1 to Thy5. Intermediate Thy3 FNA results are challenging, as this suggests malignancy is possible, but the relatively low rates of malignancy can make decision-making difficult. Thy3 is further subdivided into Thy3a and Thy3f. BTA recommends further ultrasound with or without FNA cytology for Thy3a nodules and hemithyroidectomy for Th3yf nodules based on a published positive predictive value (PPV) for malignancy of 17% for Thy3a and up to 40% for Thy3f results. We aim to compare the actual malignancy rates of Thy3 nodules in our unit to these figures. Methods A retrospective study was performed looking at the histologically confirmed malignancy rates in Thy3a and Thy3f cytology over four years between January 2016 and December 2019. Results There were 162 separate Thy3 nodules in 156 patients included in this study, of which 60 were classified as Thy3a and 102 as Thy3f. 10% of patients with Thy3a nodules underwent repeat cytology. The histologically confirmed malignancy rate was 33% in Thy3a and 11% in Thy3f lesions. Discussion We found the rates of histologically confirmed malignancy are reversed compared to the published PPVs with a higher rate in Thy3a nodules and a lower rate in Thy3f. This suggests that the surgical decision-making and patient counselling may be based on flawed data in our unit and possibly throughout the UK, making a wider study involving multiple centers desirable.

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“…41,42 In contrast, Thy3a has shown a range in surgical management (21%) with discrepant malignancy outcomes, from 15% to 50%. 43,44 Therefore, the alignment of these three diagnostic terminologies and the emergence of a single, internationally agreed upon system could potentially provide the necessary platform to design larger studies. This international effort could significantly aid in the identification of those cytologic and clinical features that better correlate with malignancy.…”

Section: Introductionmentioning

confidence: 99%

Terminology and nomenclature schemes for reporting thyroid cytopathology: An overview

Collins

Rossi

Chandra

et al. 2015

Seminars in Diagnostic Pathology

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Clinical applicability of the Thy3a cytological category in thyroid nodules aspirates. Our experience in one hundred and fifty‐seven patients with Thy3 cytology

Cited by 5 publications

References 7 publications

Risk of malignancy in the various categories of the UK Royal College of Pathologists Thy terminology for thyroid FNA cytology: A systematic review and meta‐analysis

Risk of malignancy in the various categories of the UK Royal College of Pathologists Thy terminology for thyroid FNA cytology: A systematic review and meta‐analysis

Have We Got Thy3 Wrong in the UK? A Four-Year Single-Site Analysis of Malignancy Rates in Thy3 Nodules

Terminology and nomenclature schemes for reporting thyroid cytopathology: An overview

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