Clinical Application of Exhaled Nitric Oxide Measurements in a Korean Population

Song, Woo-Jung; Kwon, Ji‐Won; Kim, Eun Jin; Lee, Sang‐Min; Kim, Sae‐Hoon; Lee, So‐Yeon; Kim, Sang‐Heon; Park, Heung-Woo; Chang, Yoon‐Seok; Kim, Woo Kyung; Shim, Jung Yeon; Seo, Ju‐Hee; Kim, Byoung-Ju; Kim, Hyo Bin; Song, Dae Jin; Jang, Gwang Cheon; Jang, An‐Soo; Park, Jung-Won; Yoon, Haesang; Lee, Joo-Shil; Cho, Sang Heon; Hong, Soo‐Jong

doi:10.4168/aair.2015.7.1.3

Cited by 27 publications

(29 citation statements)

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“…An elevated eNO >35 ppb,15 which is a significantly higher value than that of 95% upper limit of Korean healthy elementary school children,16 was interpreted as having asthma. However, low eNO could not exclude asthma because eNO can vary according to the age, height, weight, gender, the presence of atopy, and the analytic instruments 17. Finally, for those who were between 3 and 5 years of age, typical asthmatic symptoms plus either a positive mAPI or objective measures of asthmatic airways, i.e.…”

Section: Methodsmentioning

confidence: 99%

Asthma Severity and the Controller Prescription in Children at 12 Tertiary Hospitals

Suh

Yang

Kim

et al. 2017

Allergy Asthma Immunol Res

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PurposeGuidelines need to be tailored to where they are applied. We aimed to describe the distinctive asthma severity profile and the pattern of controller prescription in Korean children.MethodsTwelve pediatric allergists from tertiary medical centers reviewed medical records of all asthmatic children who visited their clinics between September 1 and November 30 of 2013. Controller prescriptions were re-classified into 4 categories, then the prevalence of each asthma severity category and the controller prescription patterns according to asthma severity assessed by a Western (Global Initiative for Asthma, GINA) and an Asia-Pacific (Japanese Pediatric GuideLine, JPGL) guideline were evaluated.ResultsA total of 840 cases were reviewed. Both GINA and JPGL revealed that 328 (39.0%) and 249 (29.6%) subjects had intermittent asthma whereas 24 (2.9%) and 21 (2.5%) subjects had severe persistent asthma, respectively. Although higher category controllers tended to be prescribed to those who had more severe asthma, there was much overlap in categories of prescribed controllers between groups with regard to asthma severities. Leukotriene receptor antagonists (LTRA) was the most frequently prescribed as a single controller (40%) or as an add-on medication (19%) in the group of asthmatic children <6 years.ConclusionsKorean children have distinctive patterns of asthma severity and management strategies with a lower prevalence of severe asthma and a preference toward LTRA rather than low dose inhaled corticosteroids (ICS) alone or add-on long-acting beta-agonist (LABA) in the group of <6 year-old asthmatics that has not been predicted in Western countries. Thus, strategies tailored to regional situations need to be developed and recommended.

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Section: Methodsmentioning

confidence: 99%

Asthma Severity and the Controller Prescription in Children at 12 Tertiary Hospitals

Suh

Yang

Kim

et al. 2017

Allergy Asthma Immunol Res

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“…Clinically and scientifically, there is considerable interest in eNO measurements. Many recent studies have suggested that eNO is useful as a biomarker for diagnosing asthma and predicting steroid responsiveness in airway inflammatory diseases, such as chronic obstructive pulmonary disease (COPD) .…”

Section: Introductionmentioning

confidence: 99%

The clinical value of exhaled nitric oxide in patients with lung cancer

Liu

Zhao

Yan

et al. 2016

Clinical Respiratory J

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Introduction and Objectives: To investigate the clinical value of fractional exhaled nitric oxide (FeNO) in lung cancer patients. Methods: A total of 172 healthy control subjects and 164 patients with histopathologically confirmed lung cancer were enrolled in this study. The FeNO measurements and pulmonary function tests were conducted in the Chinese PLA General Hospital. The recorded data included FeNO, the forced expiratory volume in one second (FEV 1 ), the forced vital capacity (FVC), FEV 1 /FVC, the FEV 1 (% predicted), the demographic characteristics, the presence of complications and the smoking status. Results: The patients with lung cancer had a significantly higher level of eNO than the healthy control subjects (33.85 6 15.63 ppb, n 5 163; 16.83 6 4.17 ppb, n 5 172; P < 0.01). The areas under receiver operating characteristic curves for eNO predicting airway inflammation in lung cancer subjects and healthy control subjects was 0.932 (95% confidence interval: 0.904-0.961). In the lung cancer group, the eNO levels in the squamous cell carcinoma, adenocarcinoma, small-cell lung cancer and lung carcinoid tumor groups were significantly different (P < 0.01). Lung cancer patients with a predicted FEV 1 % value <80% had a higher level of eNO than the patients with a predicted FEV 1 % value 80%. Conclusions: The eNO levels in patients with lung cancer were higher than the normal level, especially in the patients with squamous cell carcinoma and small-cell lung cancer. The differences in eNO among the lung cancer subtypes were statistically significant. Measuring eNO will be helpful in diagnosing airway inflammation in lung cancer and in the classification of lung cancer.Please cite this paper as:

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“…However, it should be noted that the reference values were obtained from relatively small numbers of studies conducted in Western populations [6, 7]. For FeNO analyses, the potential discrepancy between different ethnic or demographic groups have been suggested (frequently higher in Asians than Caucasians) [11, 14]. That was a motivation that we attempted to determine reference ranges in Korean adults in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…Briefly, they were asked to avoid medication or food intake which could interfere with the results. They were also instructed to avoid smoking or exercise within one hour before on the day of testing [14]. Then, they inhaled over 2-3 seconds to total lung capacity through NIOX filter, and exhaled as an upper airway pressure of 5-20 cm H 2 O. FeNO was measured during its plateau status at least for 3 seconds.…”

Section: Methodsmentioning

confidence: 99%

Reference ranges for induced sputum eosinophil counts in Korean adult population

Kim

Lee

et al. 2014

Asia Pacific Allergy

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BackgroundInduced sputum analyses are widely utilized to evaluate airway inflammation in asthmatics. However, the values have not been examined in Korean adults.ObjectiveThe purpose of this study is to determine reference ranges for induced sputum eosinophils and their influencing factors in Korean adults.MethodsA total of 208 healthy nonasthmatic adults were recruited. Sputum induction and processing followed the international standard protocols.ResultsAdequate sputum samples were successfully collected from 81 subjects (38.9%). The upper 90 percentile for sputum eosinophil was calculated as 3.5%. The median value of eosinophil count percentage was significantly higher in subjects with atopy than those without atopy (median, 1.6%; range, 0-11.0% vs. median, 0%; range 0-3.6%, p=0.030). However, no significant correlations were found with age, gender, body mass index, smoking status, blood eosinophil, or fractional exhaled nitric oxide levels.ConclusionCurrent study was the first attempt to determine the reference ranges of induced sputum eosinophils in Korean adults. The cutoff value for sputum eosinophilia was 3.5%, and was significantly associated with atopy.

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Clinical Application of Exhaled Nitric Oxide Measurements in a Korean Population

Cited by 27 publications

References 100 publications

Asthma Severity and the Controller Prescription in Children at 12 Tertiary Hospitals

Asthma Severity and the Controller Prescription in Children at 12 Tertiary Hospitals

The clinical value of exhaled nitric oxide in patients with lung cancer

Reference ranges for induced sputum eosinophil counts in Korean adult population

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