Clinical application of mesenchymal stem cell in regenerative medicine: a narrative review

Abstract

The multipotency property of mesenchymal stem cells (MSCs) has attained worldwide consideration because of their immense potential for immunomodulation and their therapeutic function in tissue regeneration. MSCs can migrate to tissue injury areas to contribute to immune modulation, secrete anti-inflammatory cytokines and hide themselves from the immune system. Certainly, various investigations have revealed anti-inflammatory, anti-aging, reconstruction, and wound healing potentials of MSCs in many in vitro and in vivo models. Moreover, current progresses in the field of MSCs biology have facilitated the progress of particular guidelines and quality control approaches, which eventually lead to clinical application of MSCs. In this literature, we provided a brief overview of immunoregulatory characteristics and immunosuppressive activities of MSCs. In addition, we discussed the enhancement, utilization, and therapeutic responses of MSCs in neural, liver, kidney, bone, heart diseases, and wound healing.

Mesenchymal stem cell-derived exosomes: The dawn of diabetic wound healing

“…Stem cell-based therapies are now approved by several countries, and have been widely used in various disciplines. MSCs are currently the main experimental cell sources and have shown their excellent therapeutic potential and value in clinical trials in the field of regenerative medicine[ 16 , 54 ].…”

Cellular modifications and biomaterial design to improve mesenchymal stem cell transplantation

“…bone marrow, adipose tissue, placenta, umbilical cord, dental pulp), economics of expansion and transplantation, reduced immunogenicity, 2 and limited ethical considerations compared to their embryonic counterparts. 3 Mesenchymal stem cells have been explored in pre-clinical to clinical therapies, for neuropathies (spinal cord injury, Parkinson's disease, Alzheimer's disease), cardiomyopathies, diabetic nephropathies, cancer, and other disorders of the eye, bone, skeletomuscular tissue, cartilage, and skin. 4,5 To standardize the implementation of stem cell therapies, a reference plan was established called DOSES: Ddonor (autologous, allogenic or xenogeneic), Oorigin of tissue, Sseparation method, Eexhibited cell behaviour, Ssite of delivery.…”

A Novel Benchtop Device for Efficient and Simple Purification of Cytokines, Growth Factors and Stem Cells from Adipose Tissue

“…ADSCs display a high proliferation rate and differentiation multipotency. Moreover, they secrete multiple cytokines and proteins potentially associated with immunoregulatory and anti-inflammatory effects, making them an ideal biomedicine for tissue repair [ 6 ]. Currently, there are more than one thousand registered MSC clinical trials [ 7 ].…”