Clinical Application of the Effect of Acetone on Serum Lactate Dehydrogenase

Latner, A. L.; Turner, D.M.

doi:10.1016/s0140-6736(63)91987-1

Cited by 25 publications

(4 citation statements)

References 5 publications

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“…The relative affinities of lactate dehydrogenase isoenzymes for pyruvate and hydroxy butyrate (Wilkinson, Elliot, Cooke and Plummer, 1962), their relative heat stabilities (Wroblewski and Gregory, 1961;Latner and Skillen, 1963) and their sensitivity to acetone (Latner and Turner, 1963) have been used clinically. More recently chloroform inhibition has been shown to have some application (Warubrton, Smith and Laing, 1963).…”

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confidence: 99%

The Dehydrogenase Isoenzymes

Latner

1964

Proceedings of the Association of Clinical Biochemists

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confidence: 99%

The Dehydrogenase Isoenzymes

Latner

1964

Proceedings of the Association of Clinical Biochemists

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“…In the case of electrophoretic separation, the heart bands of LD5 and the lesser marked LD4 are reported to be still detectable two weeks after infarction (Latner and Skillen, 1961). This method is not particularly good for detecting second infarctions, rise in activity being judged by stain intensity, but the SCPK activity appears to be a very suitable test for this purpose.…”

Section: Discussionmentioning

confidence: 99%

Serum creatine phosphokinase estimations in myocardial infarction.

Warburton¹,

Bernstein²,

Wright³

1965

Heart

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“…The normal range for SGOT is 5-40 units and that for SGPT 5-35 units. The LDH was measured by the method of Berger and Broida (1964), and the acetonestable lactate dehydrogenase (ASLDH) by the method of Latner and Turner (1963). A normal figure for LDH was 250-500 BB units.…”

Section: Timing Of the Testsmentioning

confidence: 99%

Serum enzyme changes after major lung surgery--with and without halothane

Hunter¹

1968

Thorax

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The postoperative changes in serum aspartate aminotransferase (SGOT), serum alanine aminotransferase (SGPT), and lactate dehydrogenase (LDH) levels after major lung operations were studied in patients some of whom received halothane and some of whom did not. There were no differences between the two groups of cases. It seemed possible that the rises in SGOT and LDH which occurred quite frequently were an indication that tissue autolysis was occurring in the body.Retrospective statistical studies have largely discounted the risk of the development of massive hepatic necrosis as a complication of halothane anaesthesia (National Halothane Study, 1966;Mushin, Rosen, Bowen, and Campbell, 1964;Vickers and Dinnick, 1965;Henderson and Gordon, 1964). This form of investigation, however, involves a collection of data from a large number of sources with the inevitable accompanying variability in the material. One of the conclusions of the National Halothane Study was that prospective investigations of the toxicity of halothane would now be justified, and the present paper attempts this assessment.The most obvious method of detecting minor liver damage is the determination of the transaminase content of the serum of patients in the postoperative period, for such enzymes do not appear in appreciable quantity unless liver cells have been destroyed and are undergoing autolysis. A certain amount of work in this field has already been carried through (Ayres and Williard, 1960;Lawrence and Schulkins, 1956), including enzyme studies on patients to whom chloroform had been given (Fote,

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Clinical Application of the Effect of Acetone on Serum Lactate Dehydrogenase

Cited by 25 publications

References 5 publications

The Dehydrogenase Isoenzymes

The Dehydrogenase Isoenzymes

Serum creatine phosphokinase estimations in myocardial infarction.

Serum enzyme changes after major lung surgery--with and without halothane

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