Clinical applications of anterior segment swept-source optical coherence tomography: A systematic review

Mirzayev, Ibadulla; Gündüz, Ahmet Kaan; Ellialtıoğlu, Pınar Aydın; Gündüz, Ömür Özlenen

doi:10.1016/j.pdpdt.2023.103334

Cited by 19 publications

(4 citation statements)

References 226 publications

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“…To gain a more detailed understanding of corneal changes and complications following cataract surgery in uveitis patients, we recognize the potential value of incorporating advanced imaging technology in future studies. Specifically, the use of anterior segment swept-source optical coherence tomography (AS-OCT) could provide invaluable insights into the structural changes and pathologies affecting the cornea after surgery [21].…”

Section: Resultsmentioning

confidence: 99%

Early and Late Complications after Cataract Surgery in Patients with Uveitis

Bajraktari,

Jukić,

Kalauz

et al. 2023

Medicina

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Background and Objectives: Uveitis, a prevalent eye disorder characterized by inflammatory processes, often leads to cataract formation and significant visual impairment. This study aimed to evaluate preoperative conditions and postoperative outcomes following cataract surgery in uveitis patients. Materials and Methods: A retrospective study was conducted at the University Hospital Center Rebro Zagreb, Croatia, involving uveitis patients who underwent cataract surgery between 2013 and 2022. Eligible patients had uveitic cataracts affecting visual acuity or posterior segment visualization in a “quiet eye” and were disease-inactive for at least three months. Patients with certain pre-existing ocular conditions were excluded. The data collected included patient demographics, uveitis type, preoperative therapy, preexisting lesions, and postoperative outcomes such as visual acuity, intraocular pressure, central macular thickness, and complications. Statistical analysis was performed to identify risk factors associated with complications. Results: This study included 105 patients. The most common uveitis types were idiopathic uveitis, HLA-B27-associated uveitis, and JIA uveitis. After cataract surgery, there was a significant improvement in visual acuity at various time points, with 90% of eyes showing improvement. Intraocular pressure decreased over time. Central macular thickness increased at three months post-surgery but remained stable thereafter. Early and late complications were observed in 52.4% and 63.8% of eyes, respectively. The most common complications were posterior capsular opacification (53.3%), macular edema (26.6%), and epiretinal membrane formation (9.52%). The factors associated with complications varied between early and late stages but included age, age at the onset of uveitis, and the uveitis type. Conclusions: In patients with quiescent uveitis undergoing cataract surgery, significant visual improvement was achieved. This study highlights the importance of careful patient selection, preoperative and postoperative inflammation management, and precise surgical techniques. Although complications were common, the risk of capsular opacification, macular edema, and epiretinal membrane formation after surgery increased. However, future investigations should address this study’s limitations and further refine perioperative strategies.

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Section: Resultsmentioning

confidence: 99%

Early and Late Complications after Cataract Surgery in Patients with Uveitis

Bajraktari,

Jukić,

Kalauz

et al. 2023

Medicina

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“…Compared to spectral domain OCT (SD-OCT), SS-OCT achieves greater penetration, allowing better observation of tissue structure. In addition, it signi cantly improves the image acquisition speed, and further improves the axial resolution, scanning range and depth [39,40]. Thus, our study aimed to investigate the differences in AC and angle characteristics among hyperopic, emmetropic, and myopic children using SS-OCT.…”

Section: Introductionmentioning

confidence: 99%

Anterior chamber and angle characteristics in Chinese children (6-11 years old) with different refractive status using swept-source optical coherence tomography

Zhao

Tang

et al. 2023

Preprint

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Purpose To quantify and analyze the anterior chamber (AC) and angle (ACA) characteristics in Chinese children with different refractive status by swept-source optical coherence tomography (SS-OCT). Methods In a cross-sectional observational study, 383 children from two primary schools in Shandong Province, China, underwent a complete ophthalmic examination. First, the anterior chamber depth (ACD), anterior chamber width (ACW), angle-opening distance (AOD), and trabecular-iris space area (TISA) were evaluated automatically using a CASIA2 imaging device. AOD and TISA were measured at 500, 750µm nasal (N1 and N2, respectively), and temporal (T1 and T2, respectively) to the scleral spur (SS). Cycloplegic refraction and axial length (AL) were then measured. According to spherical equivalent refraction (SER), the children were assigned to hyperopic (SER > 0.50D), emmetropic (-0.50D < SER ≤ 0.50D), and myopic groups (SER ≤ -0.50D). Results Out of the 383 children, 349 healthy children (160 girls) with a mean age of 8.23 ± 1.06 years (range: 6–11 years) were included. The mean SER and AL were − 0.10 ± 1.57D and 23.44 ± 0.95mm, respectively. The mean ACD and ACW were 3.17 ± 0.24mm and 11.69 ± 0.43mm. The mean AOD were 0.72 ± 0.25, 0.63 ± 0.22mm at N1, T1, and 0.98 ± 0.30, 0.84 ± 0.27mm at N2, T2. The mean TISA were 0.24 ± 0.09, 0.22 ± 0.09mm2 at N1, T1, and 0.46 ± 0.16, 0.40 ± 0.14mm2 at N2, T2. The myopic group had the deepest AC and the widest angle. Compared with boys, girls had shorter AL, shallower ACD, narrower ACW, and ACA (all p < 0.05). By Pearson’s correlation analysis, SER was negatively associated with ACD, AOD, and TISA. AL was positively associated with ACD, ACW, AOD, and TISA. In the multiple regression analysis, AOD and TISA were associated with deeper ACD, narrower ACW, and longer AL. Conclusion In primary school students, the myopic eyes have deeper AC and wider angle. ACD, ACW, AOD, and TISA all increase with axial elongation. ACA is highly correlated with deeper ACD.

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“…While some studies suggest that cycloplegia can alter corneal curvature, anterior chamber depth, and axial length in normal eyes, others report no significant changes (15,16). Given the distinct corneal biomechanics and morphology in keratoconus, cycloplegia's effects might differ significantly from those in normal eyes (17,18). This study aims to conduct a comparative analysis of ocular biometric parameters in individuals with and without keratoconus, both pre-and post-cycloplegia (19).…”

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of Cycloplegia’s Effect on Intraocular Parameters in Keratoconus and Controls

Khan,

Kanwal,

Ullah

et al. 2023

JHRR

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Background: Cycloplegia, the paralysis of the ciliary muscle, can significantly alter ocular biometrics. However, its effect on the intraocular parameters in individuals with keratoconus (KC), a corneal condition causing visual impairment, remains inadequately understood. This study aimed to elucidate and compare the impact of cycloplegia on ocular parameters in KC patients and controls. Objective: To determine the effects of cycloplegia on anterior chamber depth (ACD), lens thickness (LT), and axial length (AL) in individuals with keratoconus compared to age-matched controls. Methods: This pre- and post-interventional study was conducted at Al-Shifa Trust Eye Hospital's Cornea Department in Rawalpindi. Subjects with KC, diagnosed using the Rabinowitz criteria, and age-matched controls were enrolled. Comprehensive anterior segment examinations, including slit lamp biomicroscopy, were performed. Cycloplegia was induced using 1% cyclopentolate. Measurements of ACD, LT, and AL were taken using the IOL Master 700, both before and after cycloplegia. Data analysis was carried out using DataTab. Results: The study encompassed 72 participants in each of the KC and control groups. The mean ages were 20.46 ± 6.47 (KC) and 22.14 ± 5.8 (controls), with a gender distribution of 58.33% male and 41.67% female in the KC group, and 54.17% male and 45.83% female in the control group. Significant differences were observed in ACD and LT pre- and post-cycloplegia in both groups, but no significant changes were noted in AL. The KC group showed changes in ACD (3.75 ± 0.28 to 3.84 ± 0.28, p < 0.001) and LT (3.49 ± 0.24 to 3.45 ± 0.24, p < 0.001), while AL remained stable (23.5 ± 0.88). Controls showed similar trends in ACD and LT with no significant change in AL. Notably, post-cycloplegia, differences in ACD and LT were significant between the KC and control groups. Conclusion: Cycloplegia significantly influences anterior chamber depth and lens thickness in both keratoconus patients and controls, while axial length remains unaffected. These findings underscore the importance of considering cycloplegic effects in ocular biometric assessments in keratoconus and normal eyes.

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Clinical applications of anterior segment swept-source optical coherence tomography: A systematic review

Cited by 19 publications

References 226 publications

Early and Late Complications after Cataract Surgery in Patients with Uveitis

Early and Late Complications after Cataract Surgery in Patients with Uveitis

Anterior chamber and angle characteristics in Chinese children (6-11 years old) with different refractive status using swept-source optical coherence tomography

Comparative Analysis of Cycloplegia’s Effect on Intraocular Parameters in Keratoconus and Controls

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