Clinical Aspects of Dermatophyte Infections

Brasch, Jochen; Hipler, Uta‐Christina

doi:10.1007/978-3-540-79307-6_13

Cited by 6 publications

(3 citation statements)

References 183 publications

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“…The fungal form and localization in the model have not been clarified in detail, and those were histopathologically examined in this study. The histopathological observation showed that most fungi in the nails of the guinea pig model were present in an arthrospore form, as reported in human nails [ 18 ]. Moreover, several fungi infected the nail plate rather than the nail’s surface.…”

Section: Discussionmentioning

confidence: 65%

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Evaluation of Topical Antifungals Using a New Predictive Animal Model for Efficacy against Severe Tinea Unguium: A Comparison of Efinaconazole and Luliconazole

et al. 2022

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Development of new topical drugs requires an animal onychomycosis model that can predict the drug efficacy against moderate to severe human onychomycosis because the severity of onychomycosis varies and affects the drug efficacy. This study established a non-immunosuppressive guinea pig tinea unguium model under 8-week infection condition in addition to a previously reported model under 4-week infection condition. In the tinea unguium model, most fungi were tightly present in the arthrospore form, like in human onychomycosis. The topical formulations of efinaconazole and luliconazole, two azole class anti-onychomycosis drugs, were evaluated for their efficacy in these models. In the untreated group, the nail fungal burden in the 8-week model was higher than that in the 4-week model and the stronger infection intensity affected the efficacy of the drugs, suggesting that the 8-week model was more severe. The 90% efficacy rate (42%) of luliconazole in the 8-week model was significantly lowered than that (83%) in the 4-week model, and its 99% efficacy rates were 0% in both models. Conversely, the 90% and 99% efficacy rates of efinaconazole (92% and 50% in the 4-week model, and 75% and 25% in the 8-week model, respectively) were not significantly different between the two infection durations. In addition, efinaconazole was more effective than luliconazole in reducing the nail fungal burden. Considering the relevance of clinical reports of the effectiveness of efinaconazole on severe onychomycosis, the new severe tinea unguium model would predict drug efficacy against moderate to severe onychomycosis.

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Section: Discussionmentioning

confidence: 65%

“…Dermatophytes form arthrospores in the human nails and the stratum corneum of the human skin [ 18 ]. Arthrospore formation is believed to be primarily responsible for dermatophyte infection and transmission in humans [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Topical Antifungals Using a New Predictive Animal Model for Efficacy against Severe Tinea Unguium: A Comparison of Efinaconazole and Luliconazole

et al. 2022

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“…There cent prevalence of 6 dermatophytos is in India ranges from 36.6-78.4%. Skin mycosis is the most frequent form of skin infections 7,8 accounting for 20-25% of world population. Currently, dermatologists across India are inundated with cases of dermatophytosis presenting with unusual large lesions, ring within ring lesions, multiple site lesions (tinea cruris et corporis), and corticosteroid modified lesions, making diagnosis a difficult bet.…”

Section: Introductionmentioning

confidence: 99%

Across-Sectional Study on Prevalence of Qooba (Ring Worm) in Adult Rural Population in the Age Group of 30-60 Years

Aamir¹,

Ansari²,

Safee³

2022

IJUM

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Introduction: Currently, dermatologists across India are inundated with cases of dermatophytosis presenting with unusual large lesions, ring within ring lesions, multiple site lesions (tinea cruris et corporis), and corticosteroid modified lesions, making diagnosis a difficult bet. This changed face of dermatophytosis has created a real panic among dermatologists. The recent prevalence of dermatophytos is in India ranges from 36.6–78.4%. Skin mycosis is the most frequent form of skin infections accounting for 20-25% of world population Dermatophytosis management has become an important public health issue, with a large void in research in the area of disease pathophysiology and management. Methodology: A cross sectional study was conducted to find out the prevalence of Qooba in adult rural population of Pune, Maharashtra. Subjects in the age group of 30 – 60 years of either gender attending the outpatient departments of hospitals from the designated study areas were included for the study. The random sampling method was used to obtain the sample of studied population. Approval of the Institutional Ethical Committee was also obtained. Assessment of subjective and objective parameters was done as per the pre-tested Performa and scales. KOH test was used as investigation of evaluation. The collected data was entered in MS-Excel and the master chart prepared accordingly data. The qualitative data was analyzed by chi square test. Result: The prevalence of dermatophytosis was 18.88%. Majority of patients (60%) having dermatophytosis were in the age group of 30-35 years. Dermatophytosis was found to be predominant in males. Itching was found in all the positive cases. The results revealed that Tinea Cruris was the most prevalent among the cases. Conclusion: Overcrowding, low socioeconomic status, unhygienic living conditions, outdoor work, increased physical activity and excessive sweating predisposes to ring worm infection. The present study showed the involvement of several fungi in dermatophytosis infection and hence detection of the causative agent is necessary for appropriate treatment of dermatophytosis.

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Synthesis and biological evaluation of (+)-labdadienedial, derivatives and precursors from (+)-sclareolide

González

Mancebo‐Aracil

Tangarife-Castaño

et al. 2010

European Journal of Medicinal Chemistry

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Clinical Aspects of Dermatophyte Infections

Cited by 6 publications

References 183 publications

Evaluation of Topical Antifungals Using a New Predictive Animal Model for Efficacy against Severe Tinea Unguium: A Comparison of Efinaconazole and Luliconazole

Evaluation of Topical Antifungals Using a New Predictive Animal Model for Efficacy against Severe Tinea Unguium: A Comparison of Efinaconazole and Luliconazole

Across-Sectional Study on Prevalence of Qooba (Ring Worm) in Adult Rural Population in the Age Group of 30-60 Years

Synthesis and biological evaluation of (+)-labdadienedial, derivatives and precursors from (+)-sclareolide

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