Clinical Aspects of Gestational Trophoblastic Disease

Richter, C.; Schwartz, Peter E.

doi:10.1007/978-1-61779-394-3_12

Cited by 1 publication

(3 citation statements)

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“…The incidence of GTD in North America and Europe has remained constant between 1–2/1000 deliveries [ 8 ]. Worldwide, the incidence of GTD has been decreasing likely due to the improved nutritional status of women in underdeveloped countries [ 2 , 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…GTD incidence is higher in both extremes of maternal age, with bimodal risk distribution [ 5 , 7 ]. Previous spontaneous abortion doubles the risk of molar pregnancy and a previous GTD is associated with 10 times increased risk of molar pregnancy [ 2 , 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…Gestational trophoblastic neoplasia (GTN), especially chorio-carcinoma is an aggressive neoplasm arising out of the uterine body with a very high propensity for metastasis [ 1 ]. Fortunately, it is also very susceptible to chemotherapy with cure rates of more than 90%, even in high-risk patients with the presence of widespread metastases [ 2 ]. It was the first medically cured solid cancer in 1956 [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

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A Rare Case of Combined Choriocarcinoma and Placental Site Trophoblastic Tumor Presenting as Skin Lesion: A Case Report

et al. 2022

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Patient: Female, 41-year-old Final Diagnosis: Choriocarcinoma • gestational thropoblastic neoplasia • placental site tumor Symptoms: Headache • scalp swelling • soft tissue swelling Medication: — Clinical Procedure: — Specialty: Dermatology • Obstetrics and Gynecology • Oncology Objective: Unusual clinical course Background: Despite the tendency to metastasize widely, Gestational Trophoblastic Neoplasia (GTN) is one of the most curable solid tumors with chemotherapy. Case Report: A 41-year-old female, G4P2A2, presented with a slowly growing lump on the left side of the scalp associated with a headache. The patient had intermittent, sharp left eye pain which radiated to the side of her face, photophobia, early morning blurring of vision, and nausea. Palpation over scalp lesion produced deep retro-orbital pain and pain was exacerbated with bending over. An ophthalmological evaluation was unremarkable. Ultrasonography (USG) of the left scalp showed an intramuscular mass superficial to the left frontal bone. During excision biopsy, the mass was found to be invading the frontal bone. Histopathology showed a metastatic trophoblastic tumor with mixed features of choriocarcinoma and placental site trophoblastic tumor. A pregnancy test was positive, the beta HCG level was elevated but USG did not show intrauterine pregnancy. CT head demonstrated an intracranial, dural-based mass that extended against the brain but did not breach the pial membrane. CT chest, abdomen, pelvis, and PET scan showed no evidence of metastatic disease. She was successfully treated with resection of the transcranial lesion followed by aggressive chemotherapy – Etoposide, Methotrexate, Actinomycin-D, Vincristine, and Cyclophosphamide. Conclusions: This was an unusual case of GTN due to its primary presentation as skin metastasis, without any lung metastasis and no identifiable primary lesion. It is also very unusual to see a combination of choriocarcinoma and placental site trophoblastic tumor cells in the same tumor mass.

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Section: Discussionmentioning

confidence: 99%