Clinical assessment of Citrosept Dental effectiveness in treatment of Candida-associated denture stomatitis, in patients using removable acrylic dentures

Abstract

Introduction. For patients using removable dentures the level of comfort and thus the life quality has substantially increased with the development of prosthetic dentistry. However, denture stomatitis, especially accompanied by fungal infections, remains a problem and affects many patients using prosthetic restorations. It is mainly caused by an increasing resistance of fungi to antifungal medications. Aim of the study. To assess clinically the effectiveness of a herbal grapefruit seed extract product called Citrosept Dental in treating Candida-associated denture stomatitis, in patients using acrylic removable dentures. Materials and methods. The studied group included 32 patients (18 women and 14 men) of the Department of Prosthetic Dentistry, Medical University of Warsaw, aged 41 to 83 years (average age 62 years), with symptoms of denture stomatitis accompanied by fungal infections, which were confirmed by a mycological test (group 1). Patients with a positive mycological test result used 1% Citrosept Dental gel on mucosal lesions three times a day after meals, for three weeks. Results. The lesions disappeared completely in 24 patients (75%) after three weeks of Citrosept Dental application. The mucosa of 13 patients with type 1 stomatitis (81.25%) was pink and healthy; that was also the case of 78.57% patients with diffuse erythema. In the three remaining patients with type 2 stomatitis lesions healed after using Citrosept Dental and only had single pinpoints of hyperaemia. There was no change in the oral mucosa of the patient with type 3 stomatitis. Conclusions. Citrosept Dental in in vivo studies reduced denture-associated mucosal inflammations in patients with denture stomatitis accompanied by fungal infections, and also produced resolution of subjective symptoms in a significant majority of patients.

Strategies for Preventing and Treating Oral Mucosal Infections Associated with Removable Dentures: A Scoping Review

“…In the domain of natural products used for managing DRS, a gel coupled with herbal grapefruit seed extract (Citrosept) resulted in a 75% remission of grade 1 and 2 inflammation. However, there was no discernible improvement in the inflammation of the oral mucosa in patients with type 3 inflammation [ 85 ].…”

“…Over this period, a notable evolution in the research landscape is evident, particularly characterized by a substantial increase in controlled clinical studies, contributing a high level of evidence to the area [ 18 , 24 , 27 , 40 , 44 , 57 , 68 , 70 , 71 , 72 , 74 , 75 , 85 , 89 , 92 , 110 , 112 , 115 ]. Employing crossover or parallel group models, these studies explored several methods, with particular emphasis on the combination of brushing and disinfection using solutions and indicated anti-biofilm effectiveness, as well as the remission of inflammation results that can be considered clinically relevant.…”

“…Ricinus communis Solution (2%) [80,135,139] Three-year simulation with 20 min daily immersion [80,135,139] One-and-a-half-year simulation with daily immersion for 8 h (overnight) [135] Tea tree Essential oils (0.188%, 0.375%, 0.5%, 0.75%, 1%) [82,86] Soak in the solutions for 1, 3, and 5 min [86] Copaiba Oil (10%) [82] Does not contain this information Herbal grapefruit seed extract Citrosept Gel (1%) [85] Three times a day for three weeks [85] Lemon grass Essential oil (0.125%, 0.25%, 0.5%, 1.0%, 0.5%) [86] Soak in the solutions for 1, 3, and 5 min [86] Cinnamomum zeylanicum Blume essential oil Essential oil spray (0.5 mg/mL) [88] Spray on dentures three times a day for 15 days [88] Propolis Gel [103] Four times a day for one week [103] Salivary polypeptides rich in histidine Mouthrinse (histidine-rich polypeptides 3 or 4) [65] Denture soak (histidine-rich polypeptides 3 or 4) [65] Mouthrinse twice a day for a period of 1 week [65] Overnight denture soak [65] Zataria multiflora Gel (0.1%) [78] Four times a day for 2 weeks [78] Table 2. Mechanical, chemical, physical, and associated methods used for the prevention and/or treatment of DRS.…”

“…In addition to denture hygiene methods for treatment of inflammation and/or mucosal infections, the literature indicates the use of a low-power laser [ 62 ], antifungals for local or systemic application, whether associated or not with photodynamic therapy [ 50 , 52 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 ], combined treatments using drugs with a local effect for stomatitis [ 73 ] and drugs with a systemic effect for patients with gastrointestinal pathologies, type 2 diabetes [ 74 ], or pathologies in the cardiovascular system [ 75 ]. Although less used, products based on organic acid, titanium dioxide, and inorganic silver antibacterial agents, and chlorine dioxide, as well as natural products used for immersion or incorporation into prosthetic materials, are also found in the literature [ 7 , 19 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 ].…”