Clinical Behavior of Prostatic Specific Antigen and Prostatic Acid Phosphatase: A Comparative Study

Robles, J. Morote; Morell, Á. Ruibal; Redorta, Joan Palou; Mateos, J A de Torres; Roselló, A Soler

doi:10.1159/000472983

Cited by 64 publications

(9 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is well-known that symptomatic prostatitis raises serum PSA level [14]. In a study of 50 acute prostatitis patients, mean serum PSA level was reported as 18.09 ng/ml [15]. Similarly, Hasui et al [16] detected positive correlation between histological acute and chronic active prostatitis and serum PSA level.…”

Section: Discussionmentioning

confidence: 93%

The correlation between serum prostate specific antigen levels and asymptomatic inflammatory prostatitis

et al. 2006

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 93%

The correlation between serum prostate specific antigen levels and asymptomatic inflammatory prostatitis

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Despite the fact that elevation of serum prostate specific antigen (PSA) levels in clinical acute prostatitis has been known for some time now, the exact underlying pathophysiological mechanisms appear largely unresolved [7][8][9][10]. Reports in the literature on the relationship between histologically confirmed prostatitis and serum PSA values are scanty [11,12] and do not appear to utilize a standardized histological classification of the prostatitis.…”

Section: Introductionmentioning

confidence: 99%

Relationship between Serum Prostate Specific Antigen and the Pattern of Inflammation in Both Benign and Malignant Prostatic Disease in Middle Eastern Men

et al. 2006

View full text Add to dashboard Cite

To determine the effect of prostatitis on serum prostate specific antigen in the diagnosis of prostate cancer in Middle Eastern men, H&E-stained sections of all consecutive prostate specimens were reviewed for diagnosis (malignant or benign) and pattern of inflammation. Inflammation was categorized into acute, active chronic and chronic inactive and graded semi-quantitatively according to previously published criteria. Results were correlated with serum PSA obtained from patients' records. Of 513 prostate specimens reviewed; 435 (84.8%) were benign and 78 (15.2%) were malignant. Chronic inactive prostatitis was present in 259 (204 benign, 55 malignant) and active chronic prostatitis in 221 (204 benign, 17 malignant). Acute prostatitis alone was not observed and prostatitis was absent in 33 (27 benign, 6 malignant). There was no significant difference in the prevalence of inactive chronic prostatitis between benign and malignant specimens (p < 0.071), but active chronic prostatitis was more prevalent in benign specimens (p < 0.001). Increasing serum PSA was observed for increasing grades of both inactive and active chronic prostatitis in both benign and malignant disease. Prostate cancer showed higher serum PSA levels than benign, at different cut-off points (4 ng/ml = p < 0.0001; 8 ng/ml = p < 0.0001; 12 ng/ml = p < 0.0001). However, significant numbers of patients with benign prostate biopsies presented with PSA above 12 ng/ml (82/260 = 32%). We conclude that active chronic prostatitis is common in Middle Eastern men with benign prostatic disease and a significant number of these present with very high PSA levels, some over 300 ng/ml.

show abstract

“…The utility of prostate specific antigen (PSA) has been well documented in the diagnosis [ 1,2,3], staging [3,4], and management [4,5] of patients with prostatic adenocarcinoma. PSA is a serine protease, elaborated by the prostatic ductal epithelium, is detectable in the serum of males (and females in low levels), and it was first isolated from seminal plasma [6,7]. Although it is elevated in patients with prostatic adenocarcinoma, a number of nonmalignant conditions of the prostate may cause elevations in PSA, specifically benign prostatic hyperplasia (BPH), prostatic massage, surgical prostatic manipulation, and prostatitis [3, 6,8].…”

Section: Introductionmentioning

confidence: 99%

“…PSA is a serine protease, elaborated by the prostatic ductal epithelium, is detectable in the serum of males (and females in low levels), and it was first isolated from seminal plasma [6,7]. Although it is elevated in patients with prostatic adenocarcinoma, a number of nonmalignant conditions of the prostate may cause elevations in PSA, specifically benign prostatic hyperplasia (BPH), prostatic massage, surgical prostatic manipulation, and prostatitis [3, 6,8]. It is clear that these conditions can cause confusion if PSA is to be used for the diagnosis and treatment of patients with prostate cancer without other tests.…”

Section: Introductionmentioning

confidence: 99%

Prostate specific antigen and prostatitis I. Effect of prostatitis on serum psa in the human and nonhuman primate

et al. 1992

View full text Add to dashboard Cite

Prostate specific antigen (PSA) has become a mainstay in the diagnosis and management of patients with prostate cancer. We have found, as have others, that it may be elevated in patients with prostatic inflammation. Ten patients had clinical evidence of prostatitis and elevated PSA levels. Six of these had persistently elevated levels after antibiotic treatment. After transrectal ultrasonography and biopsy, two had findings of adenocarcinoma, and the rest had a pathologic diagnosis of acute or chronic prostatitis. We studied this process in an experimental model of prostatitis using a nonhuman primate. We infected six cynomolgus monkeys and followed their PSA levels until resolution of the infection. The PSA peaked between 5 and 7 days after inoculation and gradually returned to baseline in 8 weeks. The dramatically elevated serum PSA levels in bacterial prostatitis can cause confusion in the diagnosis of prostatic carcinoma.

show abstract

Clinical Behavior of Prostatic Specific Antigen and Prostatic Acid Phosphatase: A Comparative Study

Cited by 64 publications

References 6 publications

The correlation between serum prostate specific antigen levels and asymptomatic inflammatory prostatitis

The correlation between serum prostate specific antigen levels and asymptomatic inflammatory prostatitis

Relationship between Serum Prostate Specific Antigen and the Pattern of Inflammation in Both Benign and Malignant Prostatic Disease in Middle Eastern Men

Prostate specific antigen and prostatitis I. Effect of prostatitis on serum psa in the human and nonhuman primate

Contact Info

Product

Resources

About