The correlation between serum prostate specific antigen levels and asymptomatic inflammatory prostatitis

Özden, Cüneyt; Ozdal, Ozdem Levent; Güzel, Özer; Han, Özge; Seçkin, Selda; Memiş, Ali

doi:10.1007/s11255-006-9125-2

Cited by 36 publications

(38 citation statements)

References 24 publications

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“…PSA might be affected by prostate volume, the grade and stage of neoplasms, patient age, and ethnicity (Partin et al, 1990). Several studies reported that the extent and grade of inflammation were correlated positively with serum PSA levels (Kandirali et al, 2007;Ozden et al, 2007). We also reported that PSA levels were positively correlated with NLR which confirms the association of inflammation and PSA.…”

Section: Discussionsupporting

confidence: 78%

Is the Neutrophil-Lymphocyte Ratio an Indicator of Progression in Patients with Benign Prostatic Hyperplasia?

Tanık

Albayrak²,

Zengın³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Purpose: The aim of this study was to evaluate inflammation parameters and assess the utility of the neutrophillymphocyte ratio (NLR) as a simple and readily available predictor for clinical disease activity in patients with nenign prostate hyperplasia BPH. We also aimed to investigate the relationship between inflammatory parameters with α-blocker therapy response, and evaluate the potential association between NLR and the progression of benign prostatic hyperplasia (BPH). Materials and Methods: We examined 320 consecutive patients ( .001); however, there were no significant differences between the groups in terms of age (p>0.05), and prostate volume (p>0.05). Conclusions: NLR can predict BPH progression. We propose that increased inflammation is negatively associated with clinical status in BPH patients and suggest that NLR can give information along with LUTS severity which may be used as a readikly accessible marker for patient follow-up.

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Section: Discussionsupporting

confidence: 78%

Is the Neutrophil-Lymphocyte Ratio an Indicator of Progression in Patients with Benign Prostatic Hyperplasia?

Tanık

Albayrak²,

Zengın³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…As reported in several studies, the extent of inflammation and grade correlated positively with the serum PSA level (28,29). Probably in the Group II we have selected patients with lower extension and grade of flogosis: this finding is also supported by the fact that between the two subsets there were no statistical significant differences in terms of total PSA.…”

Section: Discussionsupporting

confidence: 63%

Effects of Serenoa Repens, Selenium and Lycopene (Profluss®) on chronic inflammation associated with Benign Prostatic Hyperplasia: results of “FLOG” (Flogosis and Profluss in Prostatic and Genital Disease), a multicentre Italian study

et al. 2013

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Objective: To evaluate the efficacy of Profluss® on prostatic chronic inflammation (PCI). Materials and Methods:We prospectively enrolled 168 subjects affected by LUTS due to bladder outlet obstruction submitted to 12 cores prostatic biopsy for suspected prostate cancer + 2 cores collected for PCI valuation. First group consisted of 108 subjects, with histological diagnosis of PCI associated with BPH and high grade PIN and/or ASAP, randomly assigned to 1:1 ratio to daily Profluss® (group I) for 6 months or to control group (group Ic). Second group consisted of 60 subjects, with histological diagnosis of BPH, randomly assigned to 1:1 ratio to daily Profluss® + α-blockers treatment (group II) for 3 months or to control group (group IIc). After 6 months first group underwent 24 cores prostatic re-biopsy + 2 cores for PCI while after 3 months second group underwent two-cores prostatic for PCI. Specimens were evaluated for changes in inflammation parameters and for density of T-cells (CD3, CD8), B-cells (CD20) and macrophages (CD68). Results: At follow-up there were statistical significant reductions of extension and grading of flogosis, mean values of CD20, CD3, CD68 and mean PSA value in group I compared to Ic, while extension and grading of flogosis in group II were inferior to IIc but not statistical significant. A statistically significant reduction in the density of CD20, CD3, CD68, CD8 was demonstrated in group II in respect to control IIc. Conclusions: Serenoa repens+Selenium+Lycopene may have an anti-inflammatory activity that could be of interest in the treatment of PCI in BPH and/or PIN/ASAP patients.

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“…Some of these studies found that tPSA levels were significantly higher in patients with prostatitis; however, others failed to support that conclusion, stating that there was no significant association between the existence of prostatitis and tPSA levels, age and prostatic volume. [19][20][21][22][23] In the present study, neither prostatic pathology and tPSA nor age and tPSA were found to be related.…”

Section: Discussioncontrasting

confidence: 82%

The risk factors for acute urinary retention in patients with benign prostatic hyperplasia

Demirel¹,

Gökkaya²,

Özden³

et al. 2012

Turkish Journal of Urology

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ÖZETAmaç: Akut üriner retansiyonun (AUR) ensık sebebi benign prostat hiperplazisidir(BPH). AUR'un etyolojisini ayrıntılı bir şekilde araştırmak için, BPH'lı hastalarda AUR ve histolojik prostatik inflamasyon ilişkisini değerlendirdik. Gereç ve Yöntem:Çalışmaya Ocak-Aralık 2008 tarihleri arasında BPH'ne bağlı AUR veya alt üriner sistem semptomları (AÜSS) nedeniyle trans üretral rezeksiyon-prostat (TURP) yapılan 226 hasta dahil edildi. Hastalar AUR(+) (n=89) ve AUR(-) (n=137) olmak üzere 2 gruba ayrıldı. Bu iki grup; yaşlarına, rezeke edilen prostat dokusu ağırlığına (Rt), total prostat spesifik antijen (tPSA) düzeylerine ve prostat dokusu patolojisinde inflamasyon varlığına göre karşılaştırıldı. AUR için bağımsız risk faktörleri lojistik regresyon analizi ile değerlendirildi ve P değeri <0.005 ise anlamlı olarak kabul edildi. Bulgular: Bu 226 hastanın ortalama yaşları 67.7±7.7 yıl, ortalama tPSA değeri 6.45±4.97 ng/ml, ortalama rezeke edilen prostat ağırlığı (Rt) 25.47±21.77 gr. idi. Ortalama yaş ve ortalama Rt, AUR(+) grubunda diğer gruba göre anlamlı olarak daha fazla idi (p<0.0001 ve p= 0.031). Prostatik inflamasyonu olan hastalarda AUR gelişme riski olmayanlara göre anlamlı olarak daha yüksek bulundu (p= 0.049). Yapılan lojistik regresyon analizinde, 70 yaşın üzerinde, 25 gr'dan fazla doku çıkarılması ve prostatik inflamasyon varlığı AUR gelişiminde bağımsız risk faktörleri olarak bulundu.Sonuç: Sonuçlarımız göstermektedir ki; BPH'li hastalarda 70 yaşın üzerinde olmak, 25 gr'dan fazla doku çıkarılması ve prostatik inflamasyon varlığı AUR gelişiminde bağımsız risk faktörleridir.Anahtar sözcükler: Akut üriner retansiyon; benign prostat hiperplazisi; alt üriner sistem semptomları; prostat spesifik antijen. ABSTRACT Objective:The most common cause of obstructive acute urinary retention (AUR) is benign prostatic hyperplasia (BPH). To investigate the etiology of AUR, we evaluated the relationship between AUR and histological prostatic inflammation in patients with BPH. Materials and Methods:Between January and December of 2008, 226 patients who underwent transurethral resection of prostate (TURP) for AUR or lower urinary tract symptoms (LUTS) as a result of BPH were included in the study. Patients were classified into AUR(+) (n=89) and AUR(-) (n=137) groups. The two groups were compared along the following dimensions: age, weight of resected prostatic tissue (Rt), total prostate specific antigen (tPSA) levels and the presence of inflammation in the prostatic pathology. Independent risk factors for AUR were evaluated using logistic regression analysis. P values <0.05 were considered significant. Results:The mean age of the 226 patients was 67.7±7.7 years; the mean tPSA level was 6.45±4.97 ng/ml; and the mean weight of resected prostatic tissue (Rt) was 25.47±21.77 g. The mean age and Rt of the AUR(+) group were significantly higher than those of the AUR(-) group (p<0.0001 and p= 0.031, respectively). The odds of AUR were significantly higher in the patients with inflammation than in those without (p= 0.049). An age ...

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The correlation between serum prostate specific antigen levels and asymptomatic inflammatory prostatitis

Abstract: High serum PSA levels may correlate with asymptomatic inflammatory prostatitis with high aggressiveness score in BPH patients without clinical prostatitis.

Cited by 36 publications

References 24 publications

Is the Neutrophil-Lymphocyte Ratio an Indicator of Progression in Patients with Benign Prostatic Hyperplasia?

Is the Neutrophil-Lymphocyte Ratio an Indicator of Progression in Patients with Benign Prostatic Hyperplasia?

Effects of Serenoa Repens, Selenium and Lycopene (Profluss®) on chronic inflammation associated with Benign Prostatic Hyperplasia: results of “FLOG” (Flogosis and Profluss in Prostatic and Genital Disease), a multicentre Italian study

The risk factors for acute urinary retention in patients with benign prostatic hyperplasia

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