Effects of Serenoa Repens, Selenium and Lycopene (Profluss®) on chronic inflammation associated with Benign Prostatic Hyperplasia: results of “FLOG” (Flogosis and Profluss in Prostatic and Genital Disease), a multicentre Italian study

Abstract

Objective: To evaluate the efficacy of Profluss® on prostatic chronic inflammation (PCI). Materials and Methods:We prospectively enrolled 168 subjects affected by LUTS due to bladder outlet obstruction submitted to 12 cores prostatic biopsy for suspected prostate cancer + 2 cores collected for PCI valuation. First group consisted of 108 subjects, with histological diagnosis of PCI associated with BPH and high grade PIN and/or ASAP, randomly assigned to 1:1 ratio to daily Profluss® (group I) for 6 months or to control group (group Ic). Second group consisted of 60 subjects, with histological diagnosis of BPH, randomly assigned to 1:1 ratio to daily Profluss® + α-blockers treatment (group II) for 3 months or to control group (group IIc). After 6 months first group underwent 24 cores prostatic re-biopsy + 2 cores for PCI while after 3 months second group underwent two-cores prostatic for PCI. Specimens were evaluated for changes in inflammation parameters and for density of T-cells (CD3, CD8), B-cells (CD20) and macrophages (CD68). Results: At follow-up there were statistical significant reductions of extension and grading of flogosis, mean values of CD20, CD3, CD68 and mean PSA value in group I compared to Ic, while extension and grading of flogosis in group II were inferior to IIc but not statistical significant. A statistically significant reduction in the density of CD20, CD3, CD68, CD8 was demonstrated in group II in respect to control IIc. Conclusions: Serenoa repens+Selenium+Lycopene may have an anti-inflammatory activity that could be of interest in the treatment of PCI in BPH and/or PIN/ASAP patients.

Lycopene Attenuates Colistin-Induced Nephrotoxicity in Mice via Activation of the Nrf2/HO-1 Pathway

“…Another study showed that daily intake of 150 ml tomato juice (equal to administration of lycopene at approximately 15 mg/day) for 5 weeks can significantly reduce the serum concentration of 8-OhdG (8-hydroxy-2=-deoxyguanosine, a critical biomarker of oxidative stress) after extensive physical exercise (50). In addition, lycopene is the most effective quencher of oxygen free radicals across all of the naturally occurring carotenoids and demonstrates potential anticancer properties (35,51); the latter has been evaluated in clinical trials in several countries (52)(53)(54).…”

Modern extraction techniques and their impact on the pharmacological profile of Serenoa repens extracts for the treatment of lower urinary tract symptoms

“…At follow-up there were statistical significant reductions of extension and grading of flogosis (mean values of CD20, CD3, CD68, and PSA). This product may have an anti-inflammatory activity that could be of interest in the treatment of PCI in BPH [42]. …”

Multimodal therapy for category III chronic prostatitis/chronic pelvic pain syndrome in UPOINTS phenotyped patients

“…The latter was administered alone, or in the form of a combined tablet preparation (Profluss ® ; Konpharma, Rome, Italy) including S. repens (640 mg/day), lycopene (10 mg/day) and selenium (100 μg/day) (17,18). …”