Clinical Benefits and Cost Effectiveness of Acticoat as a Dressing for Donor Sites

Honari, Shari; Gibran, Nicole S.; Engrav, Loren H.; Carlson, Andrea; Heimbach, David M.

doi:10.1097/00004630-200103002-00057

Cited by 5 publications

(2 citation statements)

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“…A further study, in which nanocrystalline silver dressings were compared against topical antibiotics in 20 patients who had meshed skin grafts, showed that the dressing group had better epithelialisation of their grafts (93). There were similar results in 14 burns patients when nanocrystalline silver dressings were compared with SSD(94), and a retrospective study involving 20 patients that showed that nanocrystalline silver dressings were better than SSD in preventing MRSA colonisation of burn wounds (95). It was suggested that these novel dressings can act as a barrier in a study of 10 patients who had MRSA‐colonised chronic wounds (73).…”

Section: Experimental and Clinical Evidence In Favour Of Silver Dressmentioning

confidence: 94%

Silver dressings: their role in wound management

Leaper

2006

International Wound Journal

365

257

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Dressings have a part to play in the management of wounds; whether they are sutured or open, usually chronic wounds of many aetiologies which are healing by secondary intention. They traditionally provide a moist wound environment, but this property has been extended through simple to complex, active dressings which can handle excessive exudate, aid in debridement, and promote disorganised, stalled healing. The control of infection remains a major challenge. Inappropriate antibiotic use risks allergy, toxicity and most importantly resistance, which is much reduced by the use of topical antiseptics (such as povidone iodine and chlorhexidine). The definition of what is an antimicrobial and the recognition of infection has proven difficult. Although silver has been recognised for centuries to inhibit infection its use in wound care is relatively recent. Evidence of the efficacy of the growing number of silver dressings in clinical trials, judged by the criteria of the Cochrane Collaboration, is lacking, but there are good indications for the use of silver dressings, to remove or reduce an increasing bioburden in burns and open wounds healing by secondary intention, or to act as a barrier against cross contamination of resistant organisms such as MRSA. More laboratory, and clinical data in particular, are needed to prove the value of the many silver dressings which are now available. Some confusion persists over the measurement of toxicity and antibacterial activity but all dressings provide an antibacterial action, involving several methods of delivery. Nanocrystalline technology appears to give the highest, sustained release of silver to a wound without clear risk of toxicity.

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Section: Experimental and Clinical Evidence In Favour Of Silver Dressmentioning

confidence: 94%

Silver dressings: their role in wound management

Leaper

2006

International Wound Journal

365

257

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“…Silver has been widely used in the treatment of S. aureus infections and one of its primary modes of action has been suggested to involve disruption of bacterial membrane integrity (Randall et al, 2013). Other clinical benefits of silver wound dressings include a reduction in wound associated pain (Rustogi et al, 2005), increased epithelialisation of skin grafts (Demling and Desanti, 2002) and increased efficiency at preventing MRSA colonisation of burn wounds (Honari et al, 2011). The anti-bacterial nature of the Ag(I) ion has also been exploited by its incorporation into topical, anti-bacterial agents such as burn wound creams (e.g.…”

Section: Introductionmentioning

confidence: 99%

Proteomic analysis of the proteins released from Staphylococcus aureus following exposure to Ag(I)

Smith

McCann

Kavanagh

2013

Toxicology in Vitro

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a b s t r a c tThe silver ion (Ag(I)) has well established antimicrobial properties and is widely used in a variety of antibacterial ointments and plasters for the control of wound infections. Wounds are frequently colonised by the bacterium Staphylococcus aureus and the aim of the work presented here was to establish how S. aureus responded following exposure to Ag(I). Exposure of S. aureus to Ag(I) resulted in the release of a range of proteins from cells. Analysis of proteins released revealed a number of proteins associated with the stress response (e.g. alkaline shock protein, methionine sulfoxide reductase), virulence (e.g. signal transduction protein) and metabolism (e.g. lipase, acetate kinase, phosphoglycerate mutase). The release of toxins (e.g. a-hemolysin, bifunctional autolysin, leucocidin F) was decreased. These results indicated that, while silver is a potent antimicrobial agent, exposure of S. aureus to this metal results in the release of a variety of proteins from the cell. Many of the proteins showing increased release were antigenic and would have the potential to induce an inflammatory response at the site of infection and thus delay healing.

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