Clinical, Biochemical and Hormonal Profile of Polycystic Ovary Syndrome

Abstract

Background:The polycystic ovary syndrome is a heterogenous condition, the pathophysiology of which is multifactorial. It is considered as a systemic and metabolic disorder like hyperglycemia and insulin resistance with increased risk of type II diabetes mellitus and cardiovascular diseases. Objective: The purpose of the present study was to analyze the clinical, biochemical and hormonal profile of patients PCOS and to find out correlations among them. Methodology: This cross-sectional observational study was done including 100 diagnosed cases of PCOS attending the GOPD, BSMMU Hospital. This study was done to analyze the clinical, biochemical and hormonal characteristics of PCOS patients and to observe the correlations among them. Result: The mean age of study populations was 22.7± 6.9 years and more than half of them were overweight or obese. Menstrual abnormality like oligomenorrhoea and secondary amenorrhoea was found in 95% cases and 5% were eumenorrhic. Prevalence of hirsutism and subfertility was 69% and 50% respectively. More than half (52%) of cases had LH/FSH ratio >2 which is taken to be significant. About one-third (30%) of cases had total testosterone level above the reference range with a mean value of serum testosterone 71.4±27.9 ng/dL. Conclusion: Significant positive correlation was found among increased BMI, increased LH/FSH ratio, serum testosterone and serum TSH level. Further studies are needed to corroborate our findings and to find out the clinical, biochemical and endocrinological characteristics of our women of PCOS. [Journal of National Institute of Neurosciences Bangladesh, 2017;3(2): 94-98]

Evaluation of biochemical parameter in polycystic ovarian disease patients attending tertiary care hospital

“…As per selection criteria 50 patients diagnosed as polycystic ovarian disease and 50 healthy controls were enrolled for this study as per selection criteria. 16 Tosi et al has demonstrated that insulin resistance, as assessed by the glucose clamp technique, is a very common feature in women with PCOS, even in normalweight subjects this finding supports our study. 17 Goodarzi et al has reported that substantial heritabilities of APAs, particularly DHEAS, have been found in the general population and in women with PCOS that supports our study.…”

Study of Polycystic Ovarian Syndrome in Infertile Women in a Rural Hospital in Central India, Prospective Design

“…These elevated LH levels can harm the endometrium and oocytes by creating an unfavourable environment [13]. In more than half (52%) of the cases, LH to FSH ratio was found >2 by Nahar et al [14]. This is consistent with Begum et al findings (51%) [12].…”

Investigating Fetuin-A and Paraoxonase-1 Activity as Markers in Polycystic Ovary Syndrome Based on Body Mass Index: A Prospective Case-Control Study

“…It is characterized by polycystic ovaries, hyperandrogenism, and chronic anovulation, and is regarded as a multifactorial disorder because of its genetic and environmental onset [2,3]. Due to its systemic and metabolic pathogenesis, the risk of cardiovascular diseases, insulin resistance (IR), type II diabetes mellitus (DM), hyperinsulinemia, and dyslipidemia may increase in these patients [4,5].…”

“…Women with PCOS have hyperinsulinemia, which influences the hypothalamic-pituitary-gonadal axis, enhancing the luteinizing hormone (LH) secretion over follicle-stimulating hormone (FSH), reducing follicular maturation and sex hormone-binding globulin (SHBG), and producing ovarian androgen [ 4 ]. In addition, women with PCOS are at higher risk of other metabolic diseases such as obesity [ 6 ].…”