Clinical burden of preoperative albumin-globulin ratio in esophageal cancer patients

Oki, Satoshi; Toiyama, Yuji; Okugawa, Yoshinaga; Shimura, Takaya; Okigami, Masato; Yasuda, Hiromi; Fujikawa, Hiroyuki; Okita, Yoshiki; Yoshiyama, Shigeyuki; Hiro, Junichiro; Kobayashi, Minàko; Ohi, Masaki; Araki, Toshimitsu; Inoue, Yasuhiro; Mohri, Yasuhiko; Kusunoki, Masato

doi:10.1016/j.amjsurg.2017.04.007

Cited by 53 publications

(50 citation statements)

References 32 publications

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“…Several publications have described the AGR as a prognostic marker in patients with solid tumors (Table ) . In the present study, the ROC analysis determined that the ideal AGR cut‐off value was 1.40, which was similar to the value reported from a previous investigation into esophageal cancer (1.41) . However, the ideal AGR cut‐off value was 1.6 for patients with bladder cancer .…”

Section: Discussionsupporting

confidence: 81%

Prognostic role of the preoperative serum albumin : globulin ratio after radical nephroureterectomy for upper tract urothelial carcinoma

et al. 2018

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Section: Discussionsupporting

confidence: 81%

Prognostic role of the preoperative serum albumin : globulin ratio after radical nephroureterectomy for upper tract urothelial carcinoma

et al. 2018

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“…In fact, different studies used different methods to calculate the cutoff values for AGR. Some studies used the median value as the cutoff value (Okis et al, ), and some studies used an ROC curve analysis to find the optimal cutoff values (Duran et al, ; Shibutani et al, ). In addition, some patients were even divided into equal quartiles according to the 33rd and 66th AGR percentile (Azab et al, ).…”

Section: Discussionmentioning

confidence: 99%

Preoperative albumin‐to‐globulin ratio predicts survival in patients with non‐small‐cell lung cancer after surgery

Zhang

Zhu

et al. 2018

Journal Cellular Physiology

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The prognostic value of the preoperative albumin‐to‐globulin ratio (AGR) has not been investigated in non‐small‐cell lung cancer (NSCLC). Therefore, we aimed to assess the clinical applicability of the preoperative AGR to predict the prognosis in patients with NSCLC. We retrospectively enrolled 545 patients with stage I/II/III NSCLC who underwent surgery at our institution. The cutoff value for preoperative AGR was calculated by using a receiver operating characteristic curve analysis. A low AGR was associated with several clinicopathological variables related to tumor progression. In the multivariate analyses, the preoperative AGR was identified as an independent prognostic factor for disease‐free survival (DFS; P = 0.003) and overall survival (OS; P = 0.005). For patients with stage II and III with a preoperative AGR ≤ 1.43, the surgery plus chemotherapy group had a significantly longer DFS and OS than the surgery alone group (P = 0.002 and P = 0.001, respectively); however, a significant difference in DFS and OS between these two groups was not observed in patients with stage II and III with an AGR > 1.43 (P = 0.808 and P = 0.842, respectively). The preoperative AGR is an independent, significant predictor of DFS and OS in patients with NSCLC. Our results also demonstrate that the preoperative AGR might be a predictive marker of the therapeutic effect of postoperative chemotherapy in patients with stage II and III NSCLC.

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“…Serum globulin plays an important role in immunity and inflammation [28]. The serum AGR can reflect both malnutrition and systemic inflammation in patients with cancer [29] and has been used as a prognostic factor in various malignancies [10][11][12][13][14][15].…”

Section: Discussionmentioning

confidence: 99%

“…Previous work by our group has shown that several systemic inflammatory scores can be used as noninvasive biomarkers to predict outcomes in patients with gastrointestinal cancer [12,[15][16][17][18][19][20]. In this study, we assessed the preoperative serum AGR and other representative tumor markers to clarify their significance as predictive biomarkers for recurrence and prognosis in patients with RC.…”

Section: Introductionmentioning

confidence: 99%

“…Although the albumin-globulin ratio (AGR) was originally shown to be a clinical indicator in patients with multiple myeloma and other immunoproliferative disorders, emerging evidence has shown its potential as a predictive biomarker for long-term mortality in various solid cancers, including nasopharyngeal carcinoma [10], CRC [11,12], lung cancer [13], breast cancer [14], and esophageal cancer [15]. However, its clinical and prognostic significance in patients with neoadjuvant CRT (nCRT)-treated RC remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Impact of Preoperative Albumin-Globulin Ratio in Patients with Rectal Cancer Treated with Preoperative Chemoradiotherapy

Toiyama¹,

Oki²,

Okugawa³

et al. 2018

Oncology

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Objective: The serum albumin-globulin ratio (AGR) is associated with malignancy outcomes. However, among patients with rectal cancer (RC) who undergo neoadjuvant chemoradiotherapy (nCRT), the clinical and prognostic significance of the pretreatment AGR is unclear. Methods: We investigated whether the pre-nCRT AGR can help predict oncological outcomes in patients with RC receiving nCRT. We analyzed 114 patients with RC who received nCRT followed by total mesorectal excision at our institution. Results: A lower AGR in pre-nCRT serum was significantly correlated with shorter overall survival and disease-free survival in patients with nCRT-treated RC. In multivariate analysis, a high carcinoembryonic antigen (CEA) level and a low AGR in pre-nCRT serum were independent predictors of a poor prognosis in these patients. Furthermore, combining the AGR with CEA provided a more accurate indicator of poor prognosis and early recurrence in these patients. In particular, a low pre-nCRT AGR was a stronger indicator of a poor prognosis and early recurrence in patients without than with pathological lymph node metastasis. Combining the pre-nCRT AGR with CEA could more precisely stratify patients’ oncological outcome risks. Conclusion: Assessment of the pretreatment AGR with or without CEA can guide postoperative treatment in patients with RC who undergo nCRT.

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Clinical burden of preoperative albumin-globulin ratio in esophageal cancer patients

Cited by 53 publications

References 32 publications

Prognostic role of the preoperative serum albumin : globulin ratio after radical nephroureterectomy for upper tract urothelial carcinoma

Prognostic role of the preoperative serum albumin : globulin ratio after radical nephroureterectomy for upper tract urothelial carcinoma

Preoperative albumin‐to‐globulin ratio predicts survival in patients with non‐small‐cell lung cancer after surgery

Clinical Impact of Preoperative Albumin-Globulin Ratio in Patients with Rectal Cancer Treated with Preoperative Chemoradiotherapy

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