Clinical characteristics and molecular epidemiology of children with meningitis in Tehran, Iran: a prospective study

Pormohammad, Ali; Lashkarbolouki, S.; Azimi, Taher; Gholizadeh, Pourya; Bostanghadiri, N.; Safari, Hossein; Armin, S H; Mohtavinejad, Naser; Fallah, Fatemeh

doi:10.1016/j.nmni.2019.100594

Cited by 11 publications

(4 citation statements)

References 33 publications

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“…There were more studies available on serogroup distribution from the EM region versus the NA region. Data were available from Iran (n = 2) [ 67 , 68 ], Kuwait (n = 1) [ 51 ], Qatar (n = 1) [ 69 ], Saudi Arabia (n = 6) [ 54 – 56 , 70 – 72 ], and Turkey (n = 8) [ 57 – 59 , 73 – 77 ], in the EM region (spanning 1987–2018), and from Egypt (n = 3) [ 61 , 78 , 79 ], Morocco (n = 6) [ 80 – 85 ], and Tunisia (n = 6) [ 64 , 86 – 90 ], in the NA region (spanning 1977–2019). Serogroups A, B and W were most frequently reported in the EM region, while B and C serogroups were most frequently reported in the NA region.…”

Section: Objective 2: Imd Epidemiologymentioning

confidence: 99%

Systematic review of invasive meningococcal disease epidemiology in the Eastern Mediterranean and North Africa region

Dogu

Oordt-Speets²,

Bruijn³

et al. 2021

BMC Infect Dis

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Background Invasive meningococcal disease (IMD) represents a global health burden. However, its epidemiology in the Eastern Mediterranean (EM) and North Africa (NA) regions is currently not well understood. This review had four key objectives: to describe asymptomatic meningococcal carriage, IMD epidemiology (e.g. serogroup prevalence, case-fatality rates [CFRs]), IMD presentation and management (e.g. clinical diagnosis, antibiotic treatments) and economic impact and evaluation (including health technology assessment [HTA] recommendations) in EM and NA. Methods A systematic literature search (MEDLINE and EMBASE) was conducted (January 2000 to February 2021). Search strings included meningococcal disease and the regions/countries of interest. Identified publications were screened sequentially by title/abstract, followed by screening of the full-text article; articles were also assessed on methodological quality. Literature reviews, genetic sequencing or diagnostic accuracy studies, or other non-pertinent publication type were excluded. An additional grey literature search (non-peer-reviewed sources; start date January 2000) was conducted to the end of April 2019. Results Of the 1745 publications identified, 79 were eligible for the final analysis (n = 61 for EM and n = 19 for NA; one study was relevant to both). Asymptomatic meningococcal carriage rates were 0–33% in risk groups (e.g. military personnel, pilgrims) in EM (no data in NA). In terms of epidemiology, serogroups A, B and W were most prevalent in EM compared with serogroups B and C in NA. IMD incidence was 0–20.5/100,000 in EM and 0.1–3.75/100,000 in NA (reported by 7/15 countries in EM and 3/5 countries in NA). CFRs were heterogenous across the EM, ranging from 0 to 57.9%, but were generally lower than 50%. Limited NA data showed a CFR of 0–50%. Data were also limited in terms of IMD presentation and management, particularly relating to clinical diagnosis/antibiotic treatment. No economic evaluation or HTA studies were found. Conclusions High-risk groups remain a significant reservoir of asymptomatic meningococcal carriage. It is probable that inadequacies in national surveillance systems have contributed to the gaps identified. There is consequently a pressing need to improve national surveillance systems in order to estimate the true burden of IMD and guide appropriate prevention and control programmes in these regions.

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Section: Objective 2: Imd Epidemiologymentioning

confidence: 99%

Systematic review of invasive meningococcal disease epidemiology in the Eastern Mediterranean and North Africa region

Dogu

Oordt-Speets²,

Bruijn³

et al. 2021

BMC Infect Dis

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“…Pormohammad et al reported 60% of the bacterial causes of meningitis in children in Tehran Hib (19).…”

Section: Discussionmentioning

confidence: 99%

Natural Acquired Immunity Against Haemophilus influenzae Type-B in Patients Undergoing Hemodialysis Jahrom, Iran, 2022

et al. 2023

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Background: End stage renal disease (ESRD) patients who undergo hemodialysis treatment suffer from immune system disorders. The immunodeficiency of these patients makes them prone to various infections. Objectives: To investigate the prevalence of naturally acquired immunity against Haemophilus influenzae type-B (Hib) and its association with the duration of dialysis treatment, gender, and age of patients in hemodialysis patients in Jahrom city, Iran. Methods: This cross-sectional descriptive was conducted on ESRD patients undergoing hemodialysis treatment, referred to Jahrom Hemodialysis Center, March - August,2022. In order to determine the presence or absence of an immunity to Hib in the patients, the qualitative level of anti-Hib Polyribosyl-ribitol-phosphate (anti-Hib PRP) antibodies in the serum of the patients were determined using the ELISA test using a specialized commercial kit. SPSS-21 was used to analyze the data. The chi-square test, univariate and multivariable logistic regression were used for data analysis. Results: The prevalence of naturally acquired immunity to Hib in patients was 26.13% (10.22% short-term immunity, 15.91% long-term immunity). A significant relationship was found between the prevalence of long-term immunity to Hib in patients and the number of dialysis sessions three times per week (P < 0.001). Conclusions: Considering that hemodialysis patients in Iran are not vaccinated against Hib, 26.13% prevalence of natural immunity against Hib indicates the same prevalence of Hib infection history in hemodialysis patients. A case-control study with a large sample size on hemodialysis patients is recommended to accurately determine the prevalence of Hib and to decide whether to implement a Hib vaccination program in these patients.

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“…Otros agentes infecciosos no son estudiados de manera rutinaria, ya sea por falta de recursos o por dificultades prácticas frente al envío y manejo de la muestra. (14) En la actual investigación, no fueron posibles los estudios establecidos nacionales e internacionalmente para el diagnóstico adecuado y tratamiento oportuno de las meningoencefalitis agudas coincidiendo con Dickinson F y colaboradores, (15) lo cual nos lleva a meditar y a tener en cuenta para posteriores estudios.…”

Section: Discussionunclassified

Infections of the central nervous system in pediatric patients clinical epidemiological aspects

Cordero-Cabrera,

Álvarez Reinoso,

Serrano Pérez

et al. 2023

Salud, Ciencia y Tecnología - Serie de Conferencias

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Introducción: las infecciones del sistema nervioso central constituyen un problema de salud en el planeta. Objetivo: caracterizar clínica epidemiológicamente niños con infecciones del sistema nervioso central ingresados en el Hospital Pediátrico Provincial Docente "Pepe Portilla" de Pinar de Río en los años 2020-2021. Método: estudio observacional descriptivo, transversal. Universo: 63 pacientes con diagnóstico de infección del Sistema Nervioso Central. Se seleccionó una muestra de 40 pacientes mediante muestreo aleatorio simple. Se empleó la estadística descriptiva e inferencial. Resultados: predominó la meningoencefalitis de etiología viral en 82,5 % de la muestra, con edades de 11 a 13 años en el 75,0 %. El sexo masculino representó el 67,5 % de los casos estudiados. Se identificó la fiebre en 97,5 % de los pacientes como síntoma más frecuente. Se encontró la no lactancia materna en el 92,5 %de los pacientes como factor de riesgo asociado a las infecciones del sistema nervioso central. En el año 2020 se reportó la epilepsia en el 12,5 % de los pacientes como la más frecuente complicación y en el año 2021 representó el 20,0 %. La letalidad de la infección del sistema nervioso central se mostró en 5,0 % de los casos en el 2020 y en 2021 se presentó el desenlace fatal en 2,5 %. Conclusiones: se evidenció el importante impacto social de las infecciones del sistema nervioso central en pacientes pediátricos por su evolución clínica, resolución fatal o la presencia de secuelas.

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Clinical characteristics and molecular epidemiology of children with meningitis in Tehran, Iran: a prospective study

Cited by 11 publications

References 33 publications

Systematic review of invasive meningococcal disease epidemiology in the Eastern Mediterranean and North Africa region

Systematic review of invasive meningococcal disease epidemiology in the Eastern Mediterranean and North Africa region

Natural Acquired Immunity Against Haemophilus influenzae Type-B in Patients Undergoing Hemodialysis Jahrom, Iran, 2022

Infections of the central nervous system in pediatric patients clinical epidemiological aspects

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