Clinical Characteristics and Outcomes in 314 Japanese Patients with Bacterial Endophthalmitis: A Multicenter Cohort Study from J-CREST

Abstract

Bacterial endophthalmitis is an intraocular infection that causes rapid vison loss. Pathogens can infect the intraocular space directly (exogenous endophthalmitis (ExE)) or indirectly (endogenous endophthalmitis (EnE)). To identify predictive factors for the visual prognosis of Japanese patients with bacterial endophthalmitis, we retrospectively examined the bacterial endophthalmitis characteristics of 314 Japanese patients and performed statistics using these clinical data. Older patients, with significantly more severe clinical symptoms, were prevalent in the ExE group compared with the EnE group. However, the final best-corrected visual acuity (BCVA) was not significantly different between the ExE and EnE groups. Bacteria isolated from patients were not associated with age, sex, or presence of eye symptoms. Genus Streptococcus, Streptococcus pneumoniae, and Enterococcus were more prevalent in ExE patients than EnE patients and contributed to poor final BCVA. The presence of eye pain, bacterial identification, and poor BCVA at baseline were risk factors for final visual impairment.

Endophthalmitis in children with open eye injury: epidemiology, risk factors, treatment

“…По данным японского многоцентрового когортного исследования J-CREST (314 пациентов), среди всего спектра выделенной микрофлоры при ТЭ Enterococcus, Streptococcus pneumoniae и Genus Streptococcus обладают самой высокой вирулентностью и ассоциировались с худшими исходами для взрослых пациентов и детей. Еще одним неблагоприятным фактором считается микст-инфекция: отсутствие полимикробной инфекции улучшало прогноз ТЭ (OR = 18,03; 95% CI: 0,9-344,4; p = 0,05) [19][20][21].…”