Clinical Characteristics and Outcomes of Möbius Syndrome in a Children's Hospital

Kataoka, Ai; Yamamoto, Akira; Tanoue, Koji; Kurosawa, Kenji; Shibasaki, Jun; Ohyama, Makiko; Aida, Noriko

doi:10.1016/j.pediatrneurol.2014.08.011

Cited by 18 publications

(22 citation statements)

References 25 publications

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“…Moebius syndrome is characterized by congenital palsy of the 6th and 7th cranial nerves, but may also be associated with palsies of other cranial nerves, including the 9th and 10th, creating dysfunction of the pharynx, dysphagia, feeding difficulties, retention of oral secretions and recurrent bouts of aspiration pneumonia [8][9][10][11]25], and can also be associated with central alveolar hypoventilation. Postoperative use of opioid, sedative and anesthetic agents in th presence of central hypoventilation can predispose to grave respiratory consequences.…”

Section: Discussionmentioning

confidence: 99%

“…Postoperative use of opioid, sedative and anesthetic agents in th presence of central hypoventilation can predispose to grave respiratory consequences. In addition, postoperative pain assessment is difficult due to absence of facial expression because of the facial palsy [9,10,25,26].…”

Section: Discussionmentioning

confidence: 99%

“…These patients require somewhat specialized anesthetic care due to their abnormal airway kinetics, frequently associated congenital cardiac anomalies and positioning issues [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

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Airway Management in Neonates with Pierre Robin Syndrome along with Mobius Syndrome and Platoglossal Fusion

Elmatite¹,

Haykal²,

Upadhyay³

et al. 2017

J Anesth Clin Res

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Pierre Robin Syndrome is a rare congenital syndrome presenting challenges of airway management not only during anesthesia, but also in the Neonatal Intensive Care Unit (NICU). We present a case of Pierre Robin Syndrome which was unusual because it had Mobius Syndrome and palatoglossal fusion as comorbidies, further complicating airway management. We successfully intubated the patient using a fiberoptic laryngoscope via the nasal route.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Airway Management in Neonates with Pierre Robin Syndrome along with Mobius Syndrome and Platoglossal Fusion

Elmatite¹,

Haykal²,

Upadhyay³

et al. 2017

J Anesth Clin Res

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“…1). Abnormalities of horizontal gaze may be seen in children due to focal neurologic lesions or congenital syndromes such as Mobius syndrome or horizontal gaze palsy with progressive scoliosis [1,2]. Here, we present the unusual finding of transient horizontal gaze palsy associated with skull fracture and focal traumatic subarachnoid hemorrhage in a young infant.…”

Section: Introductionmentioning

confidence: 97%

Transient Horizontal Gaze Palsy in a One-Month-Old Boy after a Fall

Bourne

Duhaime²

2015

Pediatr Neurosurg

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A 1-month-old boy was evaluated after a fall from a height of 3 feet and found to have right parietal skull fracture as well as right and left frontal traumatic hemorrhage. Ten days after the injury, he represented with a persistent left gaze preference. Further workup including MRI and EEG determined that this finding was most likely due to a small, focal, left-frontal eye field lesion. We review the horizontal gaze pathway and demonstrate that this is present at this very young age, and that a very focal and relatively minor injury can cause gaze disturbance.

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“…Other associated manifestations include seizure disorders, congenital heart diseases, hypotonia, hypogonadotropic hypogonadism, hydrosyringomyelia, and some degree of mental retardation 2 . The cause of Moebius syndrome is unknown, but rhomboencephalic maldevelopment and brainstem ischemia between 5 to 8 weeks of gestation 3 are two possible etiological hypotheses in children with normal karyotype. The list of potential associated teratogenic events includes hyperthermia, trauma, thrombus formation, embolism, hemorrhage, as well as in utero exposure to various medications including misoprostol 4 .…”

Section: Introductionmentioning

confidence: 99%

Moebius Syndrome: Challenges of Airway Management

Budić

Surdilovic

Slavkovic

et al. 2016

ACC

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SUMMARY -Moebius syndrome is a rare nonprogressive congenital neurological disorder with a wide range of severity and variability of symptoms. This diversity is a consequence of dysfunction of different cranial nerves (most often facial and abducens nerves), accompanying orofacial abnormalities, musculoskeletal malformations, congenital cardiac diseases, as well as specific associations of Moebius and other syndromes. The authors present anesthesia and airway management during the multiple tooth extraction surgery in a 10-year-old girl with Moebius syndrome associated with Poland and trigeminal trophic syndromes.

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Clinical Characteristics and Outcomes of Möbius Syndrome in a Children's Hospital

Cited by 18 publications

References 25 publications

Airway Management in Neonates with Pierre Robin Syndrome along with Mobius Syndrome and Platoglossal Fusion

Airway Management in Neonates with Pierre Robin Syndrome along with Mobius Syndrome and Platoglossal Fusion

Transient Horizontal Gaze Palsy in a One-Month-Old Boy after a Fall

Moebius Syndrome: Challenges of Airway Management

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