Clinical characteristics and outcomes of pediatric patients with CMV DNA detection in bronchoalveolar lavage fluid

Burgener, Elizabeth B.; Waggoner, Jesse J.; Pinsky, Benjamin A.; Chen, Sharon F.

doi:10.1002/ppul.23494

Cited by 12 publications

(8 citation statements)

References 27 publications

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“…In 1988, CMV detection by rapid culture of bronchoalveolar lavage (BAL) fluid became the mainstay of diagnosis for CMV pneumonia [4]. However, while CMV DNA-specific PCR is widely used as a surveillance method for blood and serum specimens and because many laboratories have largely abandoned traditional virologic techniques, the usefulness of quantitative PCR of BAL as a diagnostic tool for CMV pneumonia is poorly defined [5][6][7][8], and the recently updated international definition guidelines provide only limited definitive evidence for using PCR as an acceptable test for disease diagnosis [9,10]. The key reason for the dilemma is that the presence of CMV DNA may not constitute disease, owing to the well-described phenomenon of pulmonary CMV shedding [11,12].…”

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confidence: 99%

Cytomegalovirus (CMV) DNA Quantitation in Bronchoalveolar Lavage Fluid From Hematopoietic Stem Cell Transplant Recipients With CMV Pneumonia

Boeckh

Stevens-Ayers²,

Travi³

et al. 2017

The Journal of Infectious Diseases

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confidence: 99%

Cytomegalovirus (CMV) DNA Quantitation in Bronchoalveolar Lavage Fluid From Hematopoietic Stem Cell Transplant Recipients With CMV Pneumonia

Boeckh

Stevens-Ayers²,

Travi³

et al. 2017

The Journal of Infectious Diseases

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“…Burgener et al reported on the clinical outcome of patients with positive CMV‐DNA detection in BAL. This is an important topic, as the definitive identification of CMV infection versus simple presence of the virus can only be established by tissue biopsy, which is often not available in children.…”

Section: Diagnostic Testing/endoscopymentioning

confidence: 99%

Pediatric Pulmonologyyear in review 2016: Part 1

et al. 2017

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Our journal covers a broad range of research and scholarly topics related to children's respiratory disorders. For updated perspectives on the rapidly expanding knowledge in our field, we will summarize the past year's publications in our major topic areas, as well as selected publications in these areas from the core clinical journal literature outside our own pages. The current review covers articles on neonatal lung disease, pulmonary physiology, and respiratory infection.Word count: 71 3

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“…Vergera et al [7] founded that cytomegalovirus (CMV ) detected positive in BALF from critically ill patients was associated with longer hospital length of stay ( HLOS ) and higher mortality rate. Meanwhile, another study on pediatric patients whose CMV DNA was detected from BALF concluded that the CMV was commonly found in BALF, which didn't mean acute dominant CMV infection and wouldn't be regarded as the rst primary diagnose [8].…”

Section: Introductionmentioning

confidence: 99%

Prognosis of lower respiratory tract infected patients with virus detected in bronchial alveolar lavage fluid: a retrospective observational study

Zhang¹,

Huang²,

Zhou³

et al. 2020

Preprint

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Background and Objectives The influence of virus detected in BALF is still debating. This study aimed to compare the prognosis of lower respiratory tract infected patients with virus detected in bronchial alveolar lavage fluid (BALF) and patients with virus undetected by using metagenomic next-generation sequencing technology.Methods This was a retrospective cohort study. 53 patients with lower respiratory tract infection were enrolled. BALF samples were collected from each patient and sent to perform mNGS pathogenic test in the study. According to the results of mNGS test, patients were divided into virus-detected group and virus-undetected group. In the meanwhile, patients’ clinical information, medical history, disease severity scores, parameters of organ function at the day of ICU admission, prognosis, hospital length of stay, ICU length of stay and needs for medical support were also collected.Results 39.6 percent (21/53) of the BALF samples were virus nucleic acid positive. Mortality rate, tracheotomy rate, mechanical ventilation supporting time, blood transfusion rate were significantly higher in virus-detected group than that in virus-undetected group. Virus-detected was closely related to hospital and ICU survival time.Conclusions Patients with virus detected in BALF were prone to a poorer prognosis. The detection of virus was a high-risk factor of death for LRTI patients. Virus-detected patients required more medical resources.

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Clinical characteristics and outcomes of pediatric patients with CMV DNA detection in bronchoalveolar lavage fluid

Abstract: CMV is frequently recovered from BAL specimens but does not usually indicate acute CMV pulmonary disease. We would suggest that other diagnoses be considered first, even if CMV is recovered. Pediatr Pulmonol. 2017;52:112-118. © 2016 Wiley Periodicals, Inc.

Cited by 12 publications

References 27 publications

Cytomegalovirus (CMV) DNA Quantitation in Bronchoalveolar Lavage Fluid From Hematopoietic Stem Cell Transplant Recipients With CMV Pneumonia

Cytomegalovirus (CMV) DNA Quantitation in Bronchoalveolar Lavage Fluid From Hematopoietic Stem Cell Transplant Recipients With CMV Pneumonia

Pediatric Pulmonologyyear in review 2016: Part 1

Prognosis of lower respiratory tract infected patients with virus detected in bronchial alveolar lavage fluid: a retrospective observational study

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