Clinical characteristics and outcomes of COVID-19 patients in Bali, Indonesia

Masyeni, Sri; Nelwan, Erni Juwita; Fatawy, Rois Muqsith; Wibawa, S.Pd. I Made Citra; Nugraha, Putu Arya; Antara, Jarwa; Suparta, Adi; Asmara, D. G. Wedha; Yenny, L. G. Sri; Budhitresna, A. A. G.; Arimas, Dewi; Indriani, Dewi; Parwata, Kmg; Sutarjana, Ketut; Sugiartha, Eka; Kahari, Siska; Wardhana, Clareza Arief; Indraningrat, Anak Agung Gede; Mulyantari, Kadek; Pasek, Arya Widiyana; Putrawan, Oka; Yustiani, Nyoman Trisna; Wardana, Gede; Wijaya, Made Indra; Aryana, Suka; Gayatri, Yuli; Sukmawati, Dewi; Suastika, Ketut; Merati, Tuti Parwati; Bakta, I Made; Widiana, Raka

doi:10.1371/journal.pone.0269026

Cited by 4 publications

(3 citation statements)

References 34 publications

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“…Previous research has shown a correlation between anosmia and mortality in COVID-19 patients ( p =0.019) [ 19 ]. A study conducted in Bali, Indonesia [ 20 ] also found a link between anosmia and death in COVID-19 patients. Prior research confirmed a significant association between anosmia and dyspnea and mortality in patients with COVID-19 [ 21 ].…”

Section: Discussionmentioning

confidence: 98%

Determinant Factors of Mortality in Pre-elderly and Elderly Patients With COVID-19 in Jakarta, Indonesia

Febrianti,

Salama,

Inggariwati

et al. 2023

J Prev Med Public Health

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Objectives: This study aimed to identify risk factors associated with coronavirus disease 2019 (COVID-19) mortality in pre-elderly and elderly individuals in Jakarta, Indonesia.Methods: We employed a case-control study design, utilizing secondary data from the Epidemiology Surveillance, Immunization Prevention, and Disease Control Sections of the DKI Jakarta Provincial Health Office, collected from December 2020 to January 2021. The study included 188 cases and an equal number of controls. Cases were COVID-19 patients confirmed to have died, as reported by hospitals and communities and subsequently verified by healthcare workers. Control subjects were patients who completed a 14-day isolation period and had been officially declared recovered by healthcare professionals. The dependent variable was the mortality of COVID-19 patients in the January 2021 period. The independent variables consisted of demographic data (age and sex), clinical symptoms (cough, runny nose, anosmia, diarrhea, headaches, abdominal pain, muscle pain, and nausea/vomiting), and comorbidities (hypertension, heart disease, and diabetes). Multivariate analysis was conducted using multiple logistic regression.Results: The multiple logistic regression analysis revealed several factors associated with COVID-19 fatalities in Jakarta: age of 60 years or older (odds ratio [OR], 4.84; 95% CI, 3.00 to 7.80), male (OR, 2.38; 95% CI, 2.41 to 3.68), dyspnea (OR, 3.93; 95% CI, 2.04 to 7.55), anosmia (OR, 0.13; 95% CI, 0.04 to 0.46), and heart disease (OR, 4.38; 95% CI, 1.04 to 18.46).Conclusions: The control and prevention of COVID-19 among elderly individuals require particular vigilance. When a COVID-19 case is detected within this demographic, prompt treatment and medication administration are crucial to mitigate the presenting symptoms.

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Section: Discussionmentioning

confidence: 98%

Determinant Factors of Mortality in Pre-elderly and Elderly Patients With COVID-19 in Jakarta, Indonesia

Febrianti,

Salama,

Inggariwati

et al. 2023

J Prev Med Public Health

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“…Similar results were found in several studies where hyperglycemia was associated with adverse conditions in COVID-19, both with comorbid DM and no comorbid DM. [31]In the case group, 75% (24 cases) of patients with hyperglycemia died, and 25% (8 cases) lived. While in cases without hyperglycemia, 64 cases (68%) lived, and 30 cases (31.9%) died.…”

Section: International Journal Of Scientific Advances Issn: 2708-7972mentioning

confidence: 99%

Hyperglycemia and Obesity as Risk Factors for Severe Covid-19

Nugraha¹,

Ngurah²,

Sajinadiyasa³

et al. 2023

International Journal of Scientific Advances

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Background: Obesity and hyperglycemia are common in patients with COVID-19 and are associated with an aggravating risk of COVID-19. This study assesses hyperglycemia and obesity as risk factors for developing severe COVID-19. Method: Analytical observational research with the design used is a matched case-control study. This study divided subjects into two groups according to the dependent variable category of severe COVID-19 as a case and not as severe as a control group. In each group, a history of hyperglycemia and obesity was traced. The analysis includes descriptive tests, bivariate with Chi-Square and multivariate with linear logistic regression using Statistical Product and Service Solutions (SPSS) 26. Result: 126 subjects divided into two groups with 63 subjects each. By age, the COVID-19 group was found to be severe, with an average of 57.9±12.731, and the COVID-19 group was not severe, with an average of 57.53±12.589. Hyperglycemia was associated with severe COVID-19 with a p-result of 0.000 (OR 11.8; CI 95% 3.819-36.456). Obesity was associated with severe COVID-19 with a result of p 0.001 (OR 4.6; CI 95% 1.8 – 11.756). Another covariant factor related to the severity of COVID-19 is Diabetes mellitus (OR: 4.6; CI 95% 2.148–10.137; p=0.028)cardiovascular disease (OR:4.7; 95% CI 1.258-17600; P=0.013),chronic lung disease(OR: 14.5; CI 95% 1.835-115.999).The results of multivariate analysis of Adj Odd Ratio10.038 (95% CI 2.447 – 41.172; P<0.001)and the association with obesity with the Adj Odd Ratio 4.846 (95% CI 1.187 – 19.789; P=0.028). Conclusion: Hyperglycemia and obesity are risk factors for severe COVID-19.

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“…The FDA authorized chloroquine sulfate and hydroxychloroquine sulfate as first-line treatments on the basis of early clinical studies. However, antiviral medications including molnupiravir, remdesivir, and kaletra (a combination medicine of lopinavir and ritonavir) have also been proposed to help COVID-19 sufferers feel better [12][13][14] .…”

Section: Introductionmentioning

confidence: 99%

Curcumin from Curcuma longa L. as Dual Inhibitors Against Indonesian SARS-CoV-2 Isolates: A Molecular Docking Study

Nidom¹,

Ansori²,

Nidom³

et al. 2023

Pharmacogn J.

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Using Lipinski's rule of five on the SCFBIO web server (http://www.scfbio-iitd. res.in/software/ drugdesign/lipinski.jsp), curcumin was utilized for further drug-likeness analysis. It was regarded as a successful forecast when two minimal guidelines ABSTRACT COVID-19 has become a global pandemic since 2020. The search for promising drugs based on the abundant herbal ingredients in Indonesia is one of the breakthroughs. Curcumin is a chemical compound with various potentials such as antioxidant, anti-inflammatory and antiviral. We conducted a molecular docking analysis to determine the potential of curcumin against SARS-CoV-2 non-structural and structural proteins, such as the main protease and spike protein. This study used the compound of curcumin (PubChem CID: 969516) from Curcuma longa L. or turmeric and two Indonesian SARS-CoV-2 isolates that have been deposited in the GISAID database (hCoV-19/Indonesia/JI-PNF-217315/2021 -EPI_ ISL_12777089 or lineage B.1.617.2 and hCoV-19/Indonesia/JI-PNF-211373/2021 -EPI_ISL_6425649 or lineage B.1.470). In addition, we used molnupiravir (PubChem CID: 145996610) as a drug control. We performed molecular docking analysis with PyRx software 0.9.9 (academic license) and visualization of molecular docking results with PyMOL software 2.5.4 (academic license). The results of this study found that curcumin had good potential against main protease and spike protein compared to the drug (control). In summary, we suggested that curcumin is a potential drug candidate against SARS-CoV-2. However, there is a need for future wet laboratory-based pre-clinical research such as in vitro and in vivo.

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Clinical characteristics and outcomes of COVID-19 patients in Bali, Indonesia

Cited by 4 publications

References 34 publications

Determinant Factors of Mortality in Pre-elderly and Elderly Patients With COVID-19 in Jakarta, Indonesia

Determinant Factors of Mortality in Pre-elderly and Elderly Patients With COVID-19 in Jakarta, Indonesia

Hyperglycemia and Obesity as Risk Factors for Severe Covid-19

Curcumin from Curcuma longa L. as Dual Inhibitors Against Indonesian SARS-CoV-2 Isolates: A Molecular Docking Study

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