Clinical Characteristics and Prognostic Factors of Lung Cancer in Korea: A Pilot Study of Data from the Korean Nationwide Lung Cancer Registry

Kim, Ho Cheol; Jung, Chi Young; Cho, Deog Gon; Jeon, Jae Hyun; Lee, Jeong Eun; Ahn, Jin Seok; Kim, Seung Joon; Kim, Yeong‐Dae; Kim, Young Chul; Kim, Jung Eun; Lee, Boram; Won, Young Joo; Choi, Chang

doi:10.4046/trd.2017.0128

Cited by 51 publications

(63 citation statements)

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“…The crude incidence rate was reported to be 35.1 per 100 000 in Korea . About 81.8% of lung cancer is histologically classified as non‐small cell lung cancer (NSCLC), with a five‐year survival rate of only 22.1% . The main reason for this dismal prognosis is that about 70% of the patients with NSCLC are diagnosed at stage III or IV …”

Section: Introductionmentioning

confidence: 99%

Efficacy of immune checkpoint inhibitors according to PD‐L1 tumor proportion scores in non‐small cell lung cancer

et al. 2019

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Background: We correlated the tumor proportion score (TPS) of programmed cell death ligand 1 (PD-L1, SP263 or 22C3) expression with the disease control rate (DCR, partial remission and stable disease), and progression free survival (PFS) after nivolumab or pembrolizumab treatment. Methods: A total of 70 case records (55 males, 15 females) of patients with nonsmall cell lung cancer (NSCLC, 46 adenocarcinoma, 22 squamous cell carcinoma, and two others) were reviewed. The PD-L1 expressions were divided into High (SP263 ≥ 30%, 22C3 ≥ 80%) and Low groups (SP263 < 30%, 22C3 < 80%). In the combined analysis, the PD-L1 group was defined as High if either of the two stains was classified as High and defined as Low if both stains were classified as Low. Results: Among the patients treated with nivolumab (n = 37), the SP263 High group showed higher DCR compared to the SP263 Low group (52.6% vs. 11.1%, P = 0.024). In patients treated with pembrolizumab (n = 33), no significant difference in DCR and PFS according to PD-L1 expression was observed. In the combined analysis (n = 36), patients in the PD-L1 High group showed significantly higher DCRs than those in the PD-L1 Low group (56.1% vs. 24.1%, P = 0.028). PFS was significantly longer in the PD-L1 High group than in the Low group (medians 4.1 vs. 1.6 months, respectively, P = 0.04). Conclusion: A high expression level of PD-L1 was correlated with a significantly higher DCR and longer PFS in NSCLC patients treated with nivolumab or pembrolizumab.

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Section: Introductionmentioning

confidence: 99%

Efficacy of immune checkpoint inhibitors according to PD‐L1 tumor proportion scores in non‐small cell lung cancer

et al. 2019

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“…The leading histopathologic subtype had changed from squamous cell carcinoma to adenocarcinoma [19]. While squamous cell carcinoma was the leading subtype in males, adenocarcinoma showed the highest incidence in females [6].…”

Section: Discussionmentioning

confidence: 99%

“…A recent Korean lung cancer epidemiology study showed that the most frequent histological subtype was adenocarcinoma [5]. Although squamous cell carcinoma was the most common subtype in male patients, adenocarcinoma was the most common subtype in female patients [6]. A few studies have looked at variations in lung cancer histology in relation to fine particulate matter, and only one study has found no clear relationships between exposure to fine particulate matter and specific histologic cancer type [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Air Pollution and Incidence of Lung Cancer by Histological Type in Korean Adults: A Korean National Health Insurance Service Health Examinee Cohort Study

Moon

Kwon

Kim

et al. 2020

IJERPH

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Studies have reported associations between long-term exposure to ambient air pollution and lung cancer. However, there have been inconsistent reports of such associations with lung cancer by histological type. Thus, the aim of this study was to assess the association of long-term exposure to particulate matter with an aerodynamic diameter up to 10 μm (PM10) and nitrogen dioxide (NO2) with lung cancer incidence by histological subtype in South Korea. This population-based cohort study included 6,567,909 cancer-free subjects from the Korean National Health Insurance Service (NHIS) database for 2006–2007. We linked population data to Korea Central Cancer Registry data to confirm lung cancer incidence for 2006–2013. Individual exposures to PM10 and NO2 were assessed as five-year average concentrations predicted at subjects’ district-specific home addresses for 2002–2007. We divided these exposures into two categories based on the 75th percentile. Cox proportional hazards models were used to estimate hazard ratios (HRs) of lung cancer incidence for the upper 25% exposure compared to the low 75% by histological subtypes at diagnosis after adjusting for potential confounders. A total of 27,518 lung cancer were found between 2006 to 2013. The incidence of lung cancer was higher in males, smokers, drinkers and subjects with chronic obstructive pulmonary disease. Overall, we did not find an increased risk of lung cancer with higher exposure to PM10 or NO2. However, high exposure to PM10 was associated with increased risk of adenocarcinoma in comparison with lower exposure in males and current smokers (HR, 1.14; 95% CI, 1.03–1.25). This study showed that long-term air pollution exposures were associated with an elevated risk of lung adenocarcinoma in male smokers in Korea.

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“…Finally, only patients diagnosed with adenocarcinoma were included in this study. Although adenocarcinoma is reported as the most common histologic type of lung cancer in South Korea, further evaluation is needed to determine whether this procedure will be effective in other cell types of lung cancer. The systemic antitumor effect of intrapleural docetaxel therapy, such as disease progression or mortality, also may need to be studied with a longer study period.…”

Section: Discussionmentioning

confidence: 99%

Effect of medical thoracoscopy‐guided intrapleural docetaxel therapy to manage malignant pleural effusion in patients with non‐small cell lung cancer: A pilot study

Choi

Park

et al. 2019

Thoracic Cancer

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Background Although chemical pleurodesis is a useful treatment option for malignant pleural effusion, little is known about the effects of intrapleural docetaxel therapy. Objectives This study aimed to evaluate the effects of medical thoracoscopy‐guided intrapleural docetaxel therapy in patients with lung cancer. Methods Patients with lung cancer who diagnosed malignant pleural effusion were enrolled in this single‐center prospective pilot study. The clinical response and toxicity were evaluated at two, six and 12 weeks post‐treatment. Results Medical thoracoscopy‐guided intrapleural docetaxel therapy was conducted in four patients between June 2016 and August 2017. The control rate of malignant pleural effusion was 100% (4/4), and the progression‐free duration of effusion was 527 ± 109 days. No serious adverse events were observed, but only mild‐to‐moderate adverse events were observed and well controlled by conservative management. Although the overall quality of life assessed using questionnaires did not show significant improvement, symptom burden due to dyspnea was significantly improved. Conclusions Intrapleural docetaxel therapy with medical thoracoscopy showed good clinical responses, relieving dyspnea symptoms and providing tolerable safety profiles in patients with non‐small cell lung cancer (NSCLC) with malignant pleural effusion. A further prospective trial is warranted to evaluate the clinical effects of intrapleural docetaxel therapy in order to compare it with other treatment modalities.

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Clinical Characteristics and Prognostic Factors of Lung Cancer in Korea: A Pilot Study of Data from the Korean Nationwide Lung Cancer Registry

Abstract: Lung cancer in Korea occurs predominantly in elderly patients, with adenocarcinoma being the most frequent subtype. The prognosis was poorer in ever-smokers and older, malnourished, and untreated patients with advanced lung cancer.

Cited by 51 publications

References 40 publications

Efficacy of immune checkpoint inhibitors according to PD‐L1 tumor proportion scores in non‐small cell lung cancer

Efficacy of immune checkpoint inhibitors according to PD‐L1 tumor proportion scores in non‐small cell lung cancer

Air Pollution and Incidence of Lung Cancer by Histological Type in Korean Adults: A Korean National Health Insurance Service Health Examinee Cohort Study

Effect of medical thoracoscopy‐guided intrapleural docetaxel therapy to manage malignant pleural effusion in patients with non‐small cell lung cancer: A pilot study

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