Clinical characteristics and risk assessment of newborns born to mothers with COVID-19

Yang, Pu; Wang, Xia; Pin, Liu; Cong, Wei; He, Bingwei; Zheng, Jiandong; Zhao, Dongchi

doi:10.1016/j.jcv.2020.104356

Cited by 172 publications

(204 citation statements)

References 6 publications

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“…On one hand, the limited available evidence suggests that vertical transmission in utero is rare, as reported in two recent series of 19 and seven pregnant infected women in China whose infants all tested negative for the virus. 26,27 On the other hand, a recent Italian report of only two cases shows horizontal mother-newborn transmission: both the infants described were exclusively breastfed and maternal milk was tested negative for SARS-CoV-2, so the way of transmission was presumably maternal droplets. One of the two newborns was completely asymptomatic, while the other showed mild symptoms (cough, diarrhea, and poor feeding) with no need for intensive care.…”

Section: Discussionmentioning

confidence: 95%

Management and Nutrition of Neonates during the COVID-19 Pandemic: A Review of the Existing Guidelines and Recommendations

Genoni¹,

Conio²,

Binotti³

et al. 2020

Am J Perinatol

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Objective We aimed at reviewing the currently available guidelines and scientific recommendations regarding the neonatal in-hospital management and feeding in the light of the coronavirus disease 2019 (COVID-19) pandemic. Study Design We systematically searched the guideline databases, Medline, Embase, and nationale/international neonatal societies websites as of June 19, 2020, for guidelines on neonatal management and feeding during the COVID-19 pandemic, at the same time assessing the methodological quality using the Appraisal of Guidelines for Research and Evaluation II tool. Results Eleven guidelines were included. The Chinese and American recommendations suggest separation of the mother and her neonate, whereas in French, Italian, UK, Canadian, and World Health Organization consensus documents the rooming-in is suggested, with Centers for Disease Control and Prevention guidelines suggesting to decide on a case-by-case basis. All the guidelines recommend breastfeeding or feeding with expressed maternal milk; the only exception is the Chinese recommendations, these last suggesting to avoid breastfeeding. Conclusion This review may provide a useful tool for clinicians and organizers, highlighting differences and similarities of the existing guidelines on the management and feeding strategies in the light of the COVID-19 pandemic. Key Points

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Section: Discussionmentioning

confidence: 95%

Management and Nutrition of Neonates during the COVID-19 Pandemic: A Review of the Existing Guidelines and Recommendations

Genoni¹,

Conio²,

Binotti³

et al. 2020

Am J Perinatol

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show abstract

“…Since the time of SARS-CoV-2003, there existed convincing evidence that aerosol-generating procedures (AGP) could potentially result in a wider human-to-human coronavirus droplet transmission radius [1]. There have been reports of COVID-19 being found in faeces and cerebral spinal fluid, but none in vaginal and amniotic fluid [2][3][4][5]. There have yet to be any studies assessing COVID-19 in peritoneal fluid.…”

Section: Introductionmentioning

confidence: 99%

COVID-19 not detected in peritoneal fluid: a case of laparoscopic appendicectomy for acute appendicitis in a COVID-19-infected patient

Ngaserin

Koh

Ong

et al. 2020

Langenbecks Arch Surg

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Purpose COVID-19 greatly affected millions and affected the way we practice with heightened posture in the way we treat surgical patients. Surgical consensus guidelines are recommending caution in the use of laparoscopy for the theoretical possibility of viral transmission from aerosolization of tissue and peritoneal fluid during surgery. However, there has yet to be proof of COVID-19 being present in peritoneal fluid, justifying the consensus statements. We aim to assess the presence of COVID-19 in peritoneal fluid. Methods We performed a laparoscopic appendicectomy for a COVID-19-infected patient with acute appendicitis. Peritoneal fluid and peritoneal washings were collected and sent for COVID-19 PCR. Results The peritoneal fluid sample collected on entry and at the end of the operation was negative for COVID-19 on PCR. The patient had an uneventful recovery from surgery.

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“…Considering the neonate, we found no evidence for any vertical transmission of COVID-19 between mother and the baby. However, there have been reported cases of early COVID-19 detection in newborns, implying the potential risk of vertical transmission (21), although in the vast majority of cases, no such evidence has been identi ed (22,23). Since only a handful of cases have been reported in the literature, vertical transmission cannot be ruled out until systematic studies have been undertaken.…”

Section: Discussionmentioning

confidence: 99%

Complicated COVID-19 in pregnancy: a case report with severe liver and coagulation dysfunction promptly improved by delivery

Ronnje

Länsberg

Vikhareva

et al. 2020

Preprint

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BackgroundIt has been proposed that pregnant women and their fetuses may be particularly at risk for poor outcomes due to the coronavirus (COVID-19) pandemic. From the few case series that are available in the literature, women with high risk pregnancies have been associated with higher morbidity. It has been suggested that pregnancy induced immune responses and cardio-vascular changes can exaggerate the course of the COVID-19 infectionCase presentationA 26-year old Somalian woman (G2P1) presented with a nine-day history of shortness of breath, dry cough, myalgia, nausea, abdominal pain and fever. A nasopharyngeal swab returned positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Her condition rapidly worsened leading to severe liver and coagulation impairment. An emergency Caesarean section was performed at gestational week 32+6 after which the patient made a rapid recovery. Severe COVID-19 promptly improved by the termination of the pregnancy or atypical HELLP (Hemolysis, Elevated Liver Enzymes and Low Platelet Count) exacerbated by concomitant COVID-19 infection could not be ruled out. There was no evidence of vertical transmission. ConclusionThis case adds to the growing body of evidence which raises concerns about the possible negative maternal outcomes of COVID-19 infection during pregnancy and advocates for pregnant women to be recognized as a vulnerable group during the current pandemic.

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Clinical characteristics and risk assessment of newborns born to mothers with COVID-19

Cited by 172 publications

References 6 publications

Management and Nutrition of Neonates during the COVID-19 Pandemic: A Review of the Existing Guidelines and Recommendations

Management and Nutrition of Neonates during the COVID-19 Pandemic: A Review of the Existing Guidelines and Recommendations

COVID-19 not detected in peritoneal fluid: a case of laparoscopic appendicectomy for acute appendicitis in a COVID-19-infected patient

Complicated COVID-19 in pregnancy: a case report with severe liver and coagulation dysfunction promptly improved by delivery

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