Clinical Characteristics and Surgical Outcomes of Carotid Body Tumors: Data from the Carotid Paraganglioma Cooperative International Registry (CAPACITY) Group

González-Urquijo, Mauricio; Viteri-Pérez, Victor Hugo; Becerril-Gaitan, Andrea; Hinojosa-González, David Eugenio; Enríquez-Vega, María Elizabeth; Guzmán, Ivan Walter Soto Vaca; Valda-Ameller, Gregorio Eloy; García-Pérez, José de Jesús; Vaquero-Puerta, Carlos; Jaramillo-Vergara, Victor Hugo; Cisneros-Tinoco, Miguel Angel; Santoscoy-Ibarra, Joaquin Miguel; Fabiani, Mario Alejandro; Cárdenas-Figueroa, Edgar Geovanny; Borja-Rojas, Verónica Elizabeth; Salinas-Ramos, Ingrid Valeria; Gonzalez-Valladares, Alfonso Juan; Katherine-Perez, Aneiva Claudia; Bañuelos-Gutierrez, Gael; Garcia-Palafox, Jesus Isaias; Gardeazabal-Diaz, Gregorio Fernando; López-Aldayuz, César Armando; Barajas-Colón, José Ángel

doi:10.1007/s00268-022-06663-1

Cited by 18 publications

(14 citation statements)

References 41 publications

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“…4 In the past, these tumors have been considered highly aggressive with a high potential for malignancy; however, nowadays, it has been proven contrariwise, with a low metastasis incidence in less than 5% of the cases. [9][10][11] For some patients, significant comorbidities, high surgical risk, or own preferences have resulted in a strategy for observation. 12 Furthermore, due to the well-known COVID-19 pandemic, some surgeries were canceled or delayed, included patients with CBT.…”

Section: Introductionmentioning

confidence: 99%

High Altitude Carotid Body Tumors Growth During active Surveillance

González-Urquijo

Hinojosa-González

Fabiani

et al. 2023

Vasc Endovascular Surg

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Background The gold standard for patients with carotid body tumors (CBT) is surgical resection; nevertheless, some patients are unfit for surgery or, for other reasons, could not be operated on. Active surveillance has been known to be a reasonable strategy for these cases. This study aimed to evaluate tumor growth in unoperated patients with CBTs. Methods A retrospective review of all unoperated patients with CBT from a single academic hospital diagnosed between 2014 and 2021 was performed. Results of nonparametric testing were presented using the median and ranges for Mann-Whitney-U or Kruskal-Wallis. Significance was defined as a 2-tailed P < .05. Results The cohort included a total of 31 patients, with a median age of 60 years (range: 37-80 years), of which 27 (87.1%) were females. The patients live at a median altitude of 2800 meters (range: 2756-2980 meters) above sea level. Twenty (64.5%) patients had Shamblin I tumors, eight (25.8%) patients had Shamblin II tumors, and three (9.7%) patients had Shamblin III tumors. Median CBT volume at diagnosis was 14.1 cm3 (range: .9 - 213.3 cm3). Median volume at diagnosis of symptomatic tumors was substantially larger than asymptomatic tumors, 49.2 cm3 vs 7.9 cm3, respectively (P = .03). Median growth of the tumors during a median 15-month follow-up (range: 3-43 months) was 3.3 cm3 (range: 0-199.9 cm3). Overall, 77% (n = 24) of the CBTs grew at least 1 cm3. Conclusion Most patients in the present study had tumor growth by at least 1 cm3, with a median tumor growth of 3.3 cm.3 In the present study tumor growth was shown to be greater than other low altitude CBT active surveillance studies; therefore, surgical resection should be recommended in patients with CBT living at high altitudes.

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Section: Introductionmentioning

confidence: 99%

High Altitude Carotid Body Tumors Growth During active Surveillance

González-Urquijo

Hinojosa-González

Fabiani

et al. 2023

Vasc Endovascular Surg

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“…Cranial nerve injury (CNI) is the most common adverse event after surgery, with an incidence of up to 15-30%, and can place a significant burden on patients' quality of life due to its disabling and long-lasting effects [8][9][10]. Most patients with CBTs are young or middle-aged.…”

Section: Introductionmentioning

confidence: 99%

Study on the Influencing Factors of Short‐Term Recovery of Neurological Symptoms after Carotid Body Tumor Resection

et al. 2023

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Objective To compare the differences in the short-term recovery from neurological symptoms (SRN) (B 6 months) and clinical characteristics of patients with different Shamblin classifications carotid body tumor (CBT) resection and to analyze the risk factors affecting SRN after surgery. Methods Patients who underwent CBT resection between June 2018 and September 2022 were recruited. Perioperative factors and indicators of the nature of the tumor were recorded. The risk factors affecting SRN after CBT resection were analyzed using logistic regression analysis. Results Eighty-five patients (43.86 ± 12.7 years, 46 females) were included, 40 (47.06%) of whom exhibited SRN. Univariate logistic regression showed that preoperative symptoms, surgical side, bilateral posterior communicating artery (PcoA) opening, some indicators of tumor size, operative/anesthesia time, and Shamblin III classification were correlated with postoperative neurological prognosis (all p \ 0.05). After adjusting for confounders, preoperative symptoms (OR, 5.072; 95% CI 1.027-25.052; p = 0.046), surgical side (OR, 0.025; 95% CI 0.003-0234; p = 0.001), bilateral PcoA opening (OR, 22.671;; p = 0.005), distance from the tip of the C2 dens to the superior aspect (dens-CBT) (OR, 0.918; 95% CI 0.858-0.982; p = 0.013) and Shamblin III classification (OR, 28.488;; p = 0.014) were correlated with postoperative neurological symptom recovery. Conclusion Preoperative symptoms, surgical side (right), bilateral PcoA opening, a short dens-CBT and Shamblin III classification are risk factors affecting SRN after CBT resection. Early resection is recommended for small-volume CBTs without neurovascular compression or invasion to obtain SRN.

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“…Solo en el 5% de los casos es bilateral 7 . En México ha sido más evidente esta relación en poblaciones que habitan sobre los 2,000 m.s.n.m., con la hipótesis de ser resultado de la estimulación hipóxica crónica 8,9 . La presentación familiar se encuentra hasta en el 10% de los tumores, mientras que aquellos cuya etiología se adjudica a la altitud se clasifican como «hiperplásicos», considerándose como los más comunes 9,10 .…”

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Experiencia quirúrgica de tumor del cuerpo carotídeo en un hospital de segundo nivel

Hernández-Sotelo¹,

Gutiérrez-Alanis²,

Jiménez-Tejeda³

et al. 2023

RMA

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Métodos: Estudio retrospectivo de la experiencia en el Hospital General Regional 2, el Marqués. Revisión de cuatro casos de tumores del cuerpo carotideo reportados durante un periodo de 3 años y 2 meses en nuestra institución. La presentación del paciente, el abordaje y la resección quirúrgica, la evolución clínica y el seguimiento fueron las variables analizadas. Resultados: Se presentaron cuatro casos, todos pacientes del sexo femenino con una edad promedio de 52 años, rango de 36 a 64, el tipo más frecuente fue Shamblin III. Todos los tumores fueron resecados con éxito, la complicación más grave fue la bradicardia transoperatoria que se presentó en un caso, los restantes sin complicaciones. Los cuatro pacientes tuvieron una evolución favorable durante el seguimiento. Conclusión: La resección quirúrgica de los Tumores de Cuerpo Carotideo se puede realizar de forma segura y eficaz con baja morbilidad y mortalidad en el segundo nivel.

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Clinical Characteristics and Surgical Outcomes of Carotid Body Tumors: Data from the Carotid Paraganglioma Cooperative International Registry (CAPACITY) Group

Cited by 18 publications

References 41 publications

High Altitude Carotid Body Tumors Growth During active Surveillance

High Altitude Carotid Body Tumors Growth During active Surveillance

Study on the Influencing Factors of Short‐Term Recovery of Neurological Symptoms after Carotid Body Tumor Resection

Experiencia quirúrgica de tumor del cuerpo carotídeo en un hospital de segundo nivel

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