Clinical Characteristics, Antimicrobial Susceptibilities, and Outcomes of Patients with &lt;i&gt;Chryseobacterium indologenes&lt;/i&gt; Bacteremia in an Intensive Care Unit

Chou, Deng-Wei; Wu, Shuling; Lee, Chao-Tai; Tai, Fan-Ting; Yu, Wen-Liang

doi:10.7883/yoken.64.520

Cited by 42 publications

(12 citation statements)

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“…In this study, C. gleum , C. indologenes , C. joostei , C. daecheongense , C. daeguense , C. shigense , C. soldanellicola , C. soli , C. ureilyticum , C. vrystaatense , C. wanjuense and E. meningoseptica were resistant to most of the antimicrobials evaluated. The findings in this study were also in agreement with those of other authors [ 61 , 62 ]. In this study, C. indologenes (isolated from soil, water and the clinical environment) and C. joostei (isolated from raw milk) were resistant to most (8/10) of the antimicrobials.…”

Section: Resultssupporting

confidence: 94%

Pathogenic Potential and Control of Chryseobacterium Species from Clinical, Fish, Food and Environmental Sources

et al. 2022

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Chryseobacterium species are isolated and taxonomically evaluated from a wide range of sources. While C. gleum and C. indologenes have been implicated in human disease, the potential pathogenicity of numerous other species have not been investigated. The aims were therefore to evaluate 37 Chryseobacterium species and Elizabethkingia meningoseptica from environmental, food, fish, water and clinical sources for production of haemolysis, growth at 37 °C, and production of virulence enzymes. The control of these strains were investigated by determination of antimicrobial and disinfectant resistance. All the species produced α- or β-haemolysis. In terms of growth at 37 °C and production of virulence enzymes, C. soldanellicola (environmental), C. oranimense (food) and C. koreense (natural mineral water) could be potential human pathogens. Chryseobacterium piscium might be pathogenic to fish. Trimethoprim could be the most effective antimicrobial for the treatment of a Chryseobacterium species infection, while the disinfectants that contain poly-dimethyl ammonium chloride or benzalkonium chloride could be regarded as the most effective for decontamination of surfaces contaminated with Chryseobacterium species.

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Section: Resultssupporting

confidence: 94%

Pathogenic Potential and Control of Chryseobacterium Species from Clinical, Fish, Food and Environmental Sources

et al. 2022

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“…Although genus Chryseobacterium is composed of more than 130 species [ 50 ], the majority of information about Chryseobacterium antibiotic resistance has been obtained from three main human-infecting species: C. indologenes , C. meningosepticum , and C. gleum [ 51 ]. Clinical Chryseobacterium isolates are known to be highly resistant to most β-lactam agents, aminoglycosides, tetracyclines, macrolides, chloramphenicol, erythromycin, and ticarcillin-clavulanate [ 11 , 26 , 52 , 53 ]. Information about the resistance of the environmental Chryseobacterium spp.…”

Section: Discussionmentioning

confidence: 99%

Novel Antibiotic Resistance Genes Identified by Functional Gene Library Screening in Stenotrophomonas maltophilia and Chryseobacterium spp. Bacteria of Soil Origin

Klimkaitė

Ragaišis

Krasauskas

et al. 2023

IJMS

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As one of the most diverse habitats of microorganisms, soil has been recognised as a reservoir of both antibiotics and the antibiotic resistance genes (ARGs). Bacteria naturally inhabiting soil or water often possess innate ARGs to counteract the chemical compounds produced by competitors living in the same environment. When such bacteria are able to cause infections in immunocompromised patients, their strong innate antibiotic resistance mechanisms make treatment difficult. We generated functional gene libraries using antibiotic-resistant Stenotrophomonas maltophilia and Chryseobacterium spp. bacteria isolated from agricultural soils in Lithuania to select for the genetic determinants responsible for their resistance. We were able to find novel variants of aminoglycoside and β-lactam resistance genes, with β-lactamases isolated from the Chryseobacterium spp. functional gene library, one of which is a variant of IND-like metallo-β-lactamase (MBL) IND-17 and the other of which is a previously uncharacterised MBL we named CHM (Chryseobacterium metallo β-lactamase). Our results indicate that soil microorganisms possess a diversity of ARG variants, which could potentially be transferred to the clinical setting.

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“…Clinically benign infections in some people are temporary and have no significant sequelae. However, because of dysfunctional or overwhelmed immune responses, bacteremia can evolve into a bloodstream infection with serious clinical symptoms, including systemic inflammatory response syndrome, sepsis, septic shock, and multiple organ dysfunction syndrome [ 5 , 6 , 7 , 8 , 9 , 10 , 11 ]. With high mortality rates after the progression to sepsis, bacteremia requires urgent treatment via appropriate antibiotics.…”

Section: Introductionmentioning

confidence: 99%

Haptoglobin-Conjugated Gold Nanoclusters as a Nanoantibiotic to Combat Bacteremia

Chu

Chen²,

Kuo

et al. 2022

Nanomaterials

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Gold nanoclusters have revealed great potential as nanoantibiotics due to their superior chemical and physical characteristics. In this study, a peptide with 83 amino acids derived from haptoglobin was utilized as a surface ligand to synthesize gold nanoclusters via a facile hydrothermal approach. Characterization of the structural and optical properties demonstrated the successful synthesis of derived haptoglobin-conjugated gold nanoclusters. The spherical derived haptoglobin-conjugated gold nanoclusters exhibited a (111) plane of cubic gold and an ultra-small size of 3.6 ± 0.1 nm. The optical properties such as ultraviolet-visible absorption spectra, X-ray photoelectron spectroscopy spectra, fluorescence spectra, and Fourier transform infrared spectra also validated the successful conjugation between the derived haptoglobin peptide and the gold nanoclusters surface. The antibacterial activity, reactive oxygen species production, and antibacterial mechanisms of derived haptoglobin-conjugated gold nanoclusters were confirmed by culturing the bacterium Escherichia coli with hemoglobin to simulate bacteremia. The surface ligand of the derived haptoglobin peptide of derived haptoglobin-conjugated gold nanoclusters was able to conjugate with hemoglobin to inhibit the growth of Escherichia coli. The derived haptoglobin-conjugated gold nanoclusters with an ultra-small size also induced reactive oxygen species production, which resulted in the death of Escherichia coli. The superior antibacterial activity of derived haptoglobin-conjugated gold nanoclusters can be attributed to the synergistic effect of the surface ligand of the derived haptoglobin peptide and the ultra-small size. Our work demonstrated derived haptoglobin-conjugated gold nanoclusters as a promising nanoantibiotic for combating bacteremia.

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Clinical Characteristics, Antimicrobial Susceptibilities, and Outcomes of Patients with <i>Chryseobacterium indologenes</i> Bacteremia in an Intensive Care Unit

Cited by 42 publications

References 0 publications

Pathogenic Potential and Control of Chryseobacterium Species from Clinical, Fish, Food and Environmental Sources

Pathogenic Potential and Control of Chryseobacterium Species from Clinical, Fish, Food and Environmental Sources

Novel Antibiotic Resistance Genes Identified by Functional Gene Library Screening in Stenotrophomonas maltophilia and Chryseobacterium spp. Bacteria of Soil Origin

Haptoglobin-Conjugated Gold Nanoclusters as a Nanoantibiotic to Combat Bacteremia

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