Clinical characteristics in obsessive-compulsive disorder with schizophrenia

Özdemir, Özay; Tükel, Raşit; Türksoy, Nuray; Üçok, Alp

doi:10.1016/s0010-440x(03)00093-2

Cited by 28 publications

(25 citation statements)

References 26 publications

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“…This trend is also evident in our study sample whereby the male to female ratio was found to be 40/13, (75.5% males compared to 24.5% females) with a preponderance of male patients diagnosed with schizophrenia or schizoaffective disorder and co-morbid OCD/OCS. This finding is in keeping with results of a Turkish study 21 of schizophrenia subjects with co-morbid OCD, were the male to female ratio was 15/5. The association between male gender and schizophrenia with co-morbid OCD needs to be explored further.…”

Section: Discussionsupporting

confidence: 91%

Prevalence and clinical characteristics of obsessive-compulsive disorder and obsessive compulsive symptoms in Afrikaner schizophrenia and schizoaffective disorder patients

Seedat

Roos²,

Pretorius³

et al. 2008

Afr. J. Psych

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Objective: There is evidence of variation in the prevalence of co-morbid obsessive-compulsive disorder in schizophrenia amongst ethnic groups. This study evaluated the lifetime prevalence and clinical characteristics of obsessive-compulsive disorder (OCD)/ obsessive-compulsive symptoms (OCS) in Afrikaner schizophrenic and schizoaffective disorder patients. Method: An ongoing genetic study of schizophrenia is currently being conducted on the Afrikaner founder population. In this cohort of 400 subjects from the original genetic study, we identified 53 subjects with schizophrenia or schizoaffective disorder and co-morbid OCD/OCS (study group). They were matched for gender and age of onset of illness with 59 subjects who do not have OCD/OCS (control group). The diagnostic instrument used in this cohort is the Diagnostic Interview for Genetic Studies (DIGS) version 2, which has been translated into Afrikaans. In addition to the DIGS, information for the relevant clinical characteristics reported in this study was also drawn from a detailed narrative chronological summary report and clinical files. A checklist was completed. Results: The prevalence of co-morbid OCD/OCS amongst 400 subjects with schizophrenia or schizoaffective disorder was 13.2% [n=53] of which 40 were male and 13 female patients. The prevalence of OCD was 10.7% and OCS was 2.5%. Contamination obsessions [n=17] were the most common type of obsession reported, followed by religious obsessions [n=8]. The most prevalent compulsions were repetitive rituals [n=32] followed by checking behaviour [n=22]. Onset of psychotic symptoms was found to be insidious in 86.8% of the study group compared to 24.6% of the control group (p<0.0001). Second-generation antipsychotic use was found to be statistically more prevalent in the study group (77.4%), compared to the control group (45.8%) (p=0.0008). 73% of the study group experienced depressive symptoms compared to 50.8% of the control group. Both groups were found to have a similar incidence of suicidal thoughts and suicide attempts. Substance abuse amongst the control group was significantly higher (35.9%) compared to the study group (19.2%) (p <0.05). Cannabis was most commonly abused in both groups, followed by alcohol. Conclusion: The prevalence rate of 13.2% of co-morbid OCD/OCS in Afrikaner schizophrenia and schizoaffective disorder patients differs from findings in other ethnic groups, suggesting the possible role of genetic and cultural factors in the prevalence of co-morbid OCD/OCS. Second-generation antipsychotic use amongst schizophrenia and schizoaffective disorder patients with co-morbid OCD/OCS was found to be significantly higher than in those without co-morbid OCD/OCS. Clinical characteristics of Afrikaner schizophrenics and schizoaffective disorder patients with and without co-morbid OCD/OCS are the same, both groups were associated with significant psychopathology and a poor prognosis. phenomena in schizophrenia at between 3-59.2%. 4 This is considerably higher than the rate of 2-3% of OCD...

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Section: Discussionsupporting

confidence: 91%

Prevalence and clinical characteristics of obsessive-compulsive disorder and obsessive compulsive symptoms in Afrikaner schizophrenia and schizoaffective disorder patients

Seedat

Roos²,

Pretorius³

et al. 2008

Afr. J. Psych

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“…Many studies have reported that OCD can be a comorbid diagnosis with SCZ or that patients with SCZ can have OCD symptoms (35)(36)(37)(38)(39)(40)(41)(42). Presented findings of a significant overlap in sMRI phenotypes along with the known SCZ/OCD genetic correlations suggests that more work should examine shared pathophysiologic features between these disorders and should assess the degree to which confounds, such as medication status or chronicity, might explain these results.…”

Section: Discussionmentioning

confidence: 94%

Structural Brain Imaging Studies Offer Clues about the Effects of the Shared Genetic Etiology among Neuropsychiatric Disorders

Radonjić

Hess

Rovira

et al. 2019

Preprint

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WordsBackground: Genomewide association studies have found significant genetic correlations among many neuropsychiatric disorders. In contrast, we know much less about the degree to which structural brain alterations are similar among disorders and, if so, the degree to which such similarities have a genetic etiology. Methods:From the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) consortium, we acquired standardized mean differences (SMDs) in regional brain volume and cortical thickness between cases and controls. We had data on 41 brain regions for: attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BD), epilepsy, major depressive disorder (MDD), obsessive compulsive disorder (OCD) and schizophrenia (SCZ). These data had been derived from 24,360 patients and 37,425 controls. Results:The SMDs were significantly correlated between SCZ and BD, OCD, MDD, and ASD. MDD was positively correlated with BD and OCD. BD was positively correlated with OCD and negatively correlated with ADHD. These pairwise correlations among disorders were significantly correlated with the corresponding pairwise correlations among disorders derived from genomewide association studies (r = 0.494; p = 0.025). Conclusions:Our results show substantial similarities in sMRI phenotypes among neuropsychiatric disorders and suggest that these similarities are accounted for, in part, by corresponding similarities in common genetic variant architectures.

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“…A number of authors have since confirmed higher rates of social impairment [54,60,66,72] and poorer functioning [56,64,65,68,70] in comorbid OCS patients. Further findings included: more affective blunting [70]; higher likelihood of an insidious onset; more negative symptoms; worse academic performance [55]; emotional distress related to OCS [56,65,68]; higher levels of positive and negative symptoms [65]; poorer cognitive performance [58,64,65,68,76]; increased motor symptoms [61,62,71]; more neurological soft signs [64]; more EPSEs [74]; and more perinatal insults and a greater prevalence of structural brain abnormalities [55].…”

Section: Comorbid Ocs/ocd and Outcomementioning

confidence: 99%

Prevalence of Comorbid Anxiety Disorders in Schizophrenia Spectrum Disorders: A Literature Review

Castle¹

2006

CPSR

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Objective: We conducted a comprehensive review of the English language literature on the comorbidity of anxiety symptoms/disorders in schizophrenia spectrum disorders (SSDs) in order to determine: their prevalence rates in clinical and non-clinical populations, the temporal relationship of anxiety comorbidity to SSDs, and the effect of comorbidity on outcome.Results: Overall lifetime prevalence rates for any anxiety disorder ranged from 30% to 85% with most studies showing rates higher than in the general population. In more than 50% of patients, the anxiety disorder preceded the onset of psychosis. Patients with comorbid panic symptoms were more frequent service users, had additional comorbidities and were more likely to be suicidal. Comorbid obsessive-compulsive symptoms (OCS) tended to be associated with poorer social functioning, worse cognitive impairment and motor symptoms.Conclusions: There is a clear link between SSDs and anxiety disorders though its nature remains unclear. This has important implications for psychiatric nosology, aetiology and treatment.

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Clinical characteristics in obsessive-compulsive disorder with schizophrenia

Cited by 28 publications

References 26 publications

Prevalence and clinical characteristics of obsessive-compulsive disorder and obsessive compulsive symptoms in Afrikaner schizophrenia and schizoaffective disorder patients

Prevalence and clinical characteristics of obsessive-compulsive disorder and obsessive compulsive symptoms in Afrikaner schizophrenia and schizoaffective disorder patients

Structural Brain Imaging Studies Offer Clues about the Effects of the Shared Genetic Etiology among Neuropsychiatric Disorders

Prevalence of Comorbid Anxiety Disorders in Schizophrenia Spectrum Disorders: A Literature Review

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