Clinical characteristics of Actinotignum schaalii bacteremia in a Japanese tertiary hospital

Nakaoka, Yusuke; Kitagawa, Hirohisa; Kohno, Hiroyuki; Koba, Yumiko; Hara, Takatoshi; Nagaoka, Rie; Tadera, Kayoko; Kashiyama, Seiya; Nomura, Toshihito; Omori, Keitaro; Shigemoto, Norifumi; Yokozaki, Michiya; Ohge, Hiroki

doi:10.1016/j.anaerobe.2022.102513

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…Gram-staining of the pus sample showed a polymicrobial pattern. The pus sample was cultured as previously described [ 17 ]. Anaerobic conditions were established using an AnaeroPack System anaerobic jar (Mitsubishi Gas Chemical Co., Inc., Tokyo, Japan) equipped with an AnaeroPack (Mitsubishi Gas Chemical Co., Inc.).…”

Section: Case Presentationmentioning

confidence: 99%

“…The two anerobic bottles were subcultured, as well as the pus sample, as previously described. The isolates were identified by using matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) as previously described [ 17 ]. On the third day of incubation, tiny colonies of small gram-negative bacillus were observed on Brucella blood agar supplemented with hemin and vitamin K1 plates cultured under anaerobic conditions.…”

Section: Case Presentationmentioning

confidence: 99%

“…The subculture plates were incubated until day 5; however, no other species grew. Then, 16S rRNA gene sequencing was performed to identify D. micraerophilus isolates, as previously described [ 17 ]. This strain showed 100% (1440/1440 bp) similarity to D. micraerophilus DSM 19965 (accession number: AF473837).…”

Section: Case Presentationmentioning

confidence: 99%

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A case of bacteremia caused by Dialister micraerophilus with Enterocloster clostridioformis and Eggerthella lenta in a patient with pyometra

Kitagawa,

Tadera,

Omori

et al. 2024

BMC Infect Dis

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Background Infection by Dialister micraerophilus, an obligate anaerobic gram-negative bacillus, has rarely been described, and its clinical characteristics remain unclear. Case presentation We report a case of bacteremia caused by D. micraerophilus, Enterocloster clostridioformis, and Eggerthella lenta in a 47-year-old woman, associated with pyometra. D. micraerophilus was identified using 16S rRNA gene sequencing and matrix-assisted laser desorption ionization time-of-flight mass spectrometry. D. micraerophilus was detected by polymerase chain reaction using D. micraerophilus-specific primers and E. clostridioformis and E. lenta was isolated from the drainage pus sample obtained from the pyometra uterus. The patient achieved a cure after abscess drainage and 2-week antibiotic treatment. Conclusions To the best of our knowledge, this is the first report of D. micraerophilus bacteremia. D. micraerophilus may be associated with gynecological infections. Clinicians should consider both oral and gynecological sites when searching to identify the focus of D. micraerophilus infection.

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Section: Case Presentationmentioning

confidence: 99%

Section: Case Presentationmentioning

confidence: 99%

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A case of bacteremia caused by Dialister micraerophilus with Enterocloster clostridioformis and Eggerthella lenta in a patient with pyometra

Kitagawa,

Tadera,

Omori

et al. 2024

BMC Infect Dis

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One case of Actinotignum schaalii-induced repeated infections at periumbilical scar accompanied by abscess formation and literature review

Li,

Yang,

et al. 2024

BMC Infect Dis

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To enhance the current clinical understanding and improve the diagnosis and treatment of Actinotignum schaalii infections, we have presented here a report of the case of recurrent infections at a periumbilical scar, induced by Actinotignum schaalii and complicated by abscess formation in a 50-year-old woman with persistent festering at the site of a periumbilical scar after laparoscopy 9 years ago, with subsequent ruptures over the past 2 years. Physical examination revealed a radial fold scar with localized redness and slight swelling of the skin below the navel. Although no significant increase in the local skin temperature was noted, tenderness was present. A rupture at the site was also observed, and gentle compression produced a small amount of odorless and yellowish viscous pus. Anerobic culturing of the pus for 3 days revealed gray-white, non-hemolytic, spore-free, gram-positive, slightly curved rod-shaped bacteria. These bacteria were identified as A. schaalii using matrix-assisted laser desorption ionization time-of-flight mass spectrometry. The patient was subsequently treated with a 1-month course of oral amoxicillin, combined with debridement and drainage. Her condition improved with regular dressing changes. However, during follow-up 6-month later, the patient presented with a recurrence of the local infection at the scar site, again accompanied by abscess formation and rupture. Notably, the wound size was smaller, and after a 1-week treatment with silver ion, without any systemic antibiotic administration, her condition improved. Next, triamcinolone acetonide combined with lidocaine was injected into the scar three times. No further local infections were observed at the scar site during the subsequent 12-month follow-up.

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Characterizing Actinotignum Schaalii Infections in a Large Canadian Healthcare Region

et al. 2022

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Aims: We characterize the epidemiology of Actinotignum schaalii within a large Canadian region after implementation of improved identification methods. Patients & methods: Positive cultures for A. schaalii from a centralized microbiology laboratory in Canada were analyzed. Clinical data were retrieved through administrative databases and chart reviews. Primary outcome was incidence of A. schaalii infections; secondary outcomes included mortality, hospital admission and length of stay. Results & conclusions: 86 unique isolates were studied, 37 bloodstream infections (BSI) and 49 non-BSIs. Patients with BSIs were older with more comorbidities, with urinary tract infections implicated as the most frequent source; skin abscesses caused the most non-BSIs. Hospitalization and 90-day mortality was higher in the BSI group. A. schaalii is an important community-acquired pathogen with the potential to cause invasive infections.

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Clinical characteristics of Actinotignum schaalii bacteremia in a Japanese tertiary hospital

Cited by 3 publications

References 18 publications

A case of bacteremia caused by Dialister micraerophilus with Enterocloster clostridioformis and Eggerthella lenta in a patient with pyometra

A case of bacteremia caused by Dialister micraerophilus with Enterocloster clostridioformis and Eggerthella lenta in a patient with pyometra

One case of Actinotignum schaalii-induced repeated infections at periumbilical scar accompanied by abscess formation and literature review

Characterizing Actinotignum Schaalii Infections in a Large Canadian Healthcare Region

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