Clinical Characteristics of Behavioral and Psychological Symptoms in Patients with Drug-naïve Alzheimer's Disease

Geriatrics Gerontology Int

Pyo

et al. 2013

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Section: Discussionmentioning

confidence: 97%

Clinical characteristics according to depression screening tools in patients with Alzheimer's disease: View from self, caregiver‐reported and drug‐intervention pattern

Geriatrics Gerontology Int

Pyo

et al. 2013

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“…The severity of anxiety seems to be stable101112 or increased during the course of dementia,13 till severe stage of dementia. From this point, anxiety gradually decreased.…”

Section: Introductionmentioning

confidence: 98%

Anxiety in Dementia

Dement Neurocognitive Disord

Koo

2017

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Until recently, there is considerable mess regarding the nature of anxiety in dementia. However, anxiety is common in this population affecting from 8% to 71% of prevalence, and resulted in poor outcome and quality of life, even after controlling for depression. Because a presentation of anxiety in the context of dementia can be different from typical early-onset anxiety disorder, it is not easy one to identify and quantify anxiety reliably. Moreover, differentiating anxiety from the depression and/or dementia itself also can be formidable task. Anxiety gradually decreases at the severe stages of dementia and this symptom may be more common in vascular dementia than in Alzheimer's disease. Due to the lack of large randomized clinical trials, optimal treatment and the true degree of efficacy of treatment is not clear yet in this population. However, these treatments can reduce adverse impact of anxiety on patients and caregivers. This article provides a brief review for the diagnosis, evaluation and treatment of anxiety in dementia.Key Words anxiety, dementia, vascular dementia, Alzheimer's disease.

“…For example, a previous cluster analysis study in drug-naïve patients with AD showed that each domain of BPSD may not be an independent entity, but may be related to each other in some ways. 58 And this study showed that aberrant motor (including wandering) symptoms and aggression, delusion, hallucination, disinhibition were clustered as the same group. The reason why these behavioral symptoms co-occur remains uncertain; however, if wandering is secondary to these symptoms, it may be helpful to manage the associated symptoms such as delusion.…”

Section: Pharmacological Managementmentioning

confidence: 65%

“…However, from both practical and moral perspectives, walking/exercise and music therapy may be acceptable interventions. 58…”

Section: Caregiver Support and Educationmentioning

confidence: 99%

Wandering in Dementia

Dement Neurocognitive Disord

Koo

2015

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Wandering is acknowledged as one of the most complex, challenging, and potentially dangerous dementia-related behaviors, and can result in elopement, injury, and even death. For the healthy people, walking is a common and a pleasurable leisure activity. However, wandering in dementia may be an exhausting behavior for caregivers and raise safety concerns. The term 'wandering' covers different types of behavior, including aimless movement without a discernible purpose. Although with respect to the etiology of wandering, biological, psychosocial and personenvironment interaction has been suggested, the etiology of wandering is poorly understood. Although it is possible that management of coexistent psychopathology would help to ameliorate this problematic behavior, evidence on the effectiveness of pharmacological and nonpharmacological interventions is limited.