Clinical characteristics of chronic venous insufficiency in patients with chronic venous leg ulcers. Part I. Clinical characteristics

Żmudzińska, Maria; Czarnecka‐Operacz, Magdalena; Silny, Wojciech

doi:10.1066/s10003060010

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“…However, MRSA was also fairly susceptible to both gentamicin (64.86%) and levofloxacin (67.57%), but choosing these drugs as first therapeutic options should be done with great caution given the increasing antibiotic resistance among MRSA strains [27]. Similar to previously published studies, Pseudomonas aeruginosa, a Gram-negative bacterium, was the second most frequent species in our study (23.04%) [17,34]. It has been shown that Pseudomonas infections might lead to a slower healing of CLU, and thus, reduce treatment responses [8].…”

Section: Resultssupporting

confidence: 86%

“…Staphylococcus aureus was the most prevalent bacteria on microbiological cultures (42.2%). Similar findings have been described in many other studies [31,17,34]. Beside a wellknown commensal species, Staphylococcus aureus is also a true pathogen responsible for a wide variety of community-associated and nosocomial infections, the latter being associated with high morbidity and mortality rates [19].…”

Section: Resultssupporting

confidence: 84%

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Antibiotic Susceptibility and Resistance of Bacterial Pathogens in Chronic Leg Ulcers: A Retrospective Cohort Study

ILUȚ¹

2023

FARMACIA

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Antimicrobial resistance has recently become a significant challenge in the medical field, affecting among others the management of chronic wounds. It is also frequently observed in dermatology, studies showing that up to 100% of chronic leg ulcers (CLU) are at some point colonized with bacterial pathogens. The aim of our study was to describe the spectrum of bacterial colonization and their antibiotic susceptibility in patients with CLU from a tertiary referral center from Romania. A total of 150 patients with at least one CLU and with a microbiological culture performed from the lesions, were included in the study. 9 bacterial species and 217 strains were identified. The most frequent bacterial pathogen was Staphylococcus aureus (42.4%), followed by Pseudomonas aeruginosa (23,04%) and Proteus spp. (13,82%). High resistance to oxacillin, erythromycin and clindamycin were found among methicillin-resistant Staphylococcus aureus strains, contrary to methicillinsusceptible Staphylococcus aureus strains that depicted high resistance to ampicillin, clindamycin and erythromycin. Pseudomonas spp., Klebsiella spp. and E. coli strains showed resistance to ciprofloxacin. In summary, these findings underline the importance of bacterial profiling and their antibiotic susceptibility in CLU. Due to the emergence of resistant bacterial strains, swab tests should be performed whenever suspecting infections in CLU before the initiation of antibiotics. RezumatRezistența antimicrobiană a devenit în ultimii ani o provocare pentru domeniul medical, afectând printre altele și managementul rănilor cronice. Frecvent observată și în dermatologie, studiile au arătat că până la 100% din ulcerele cronice de gambă (UCG) sunt la un moment dat colonizate cu bacterii. Scopul studiului nostru a fost descrierea spectrului colonizării bacteriene și a susceptibilității la antibiotice la pacienții cu UCG dintr-un spital terțiar din România. În studiu au fost incluși 150 de pacienți cu cel puțin un UCG și o cultură microbiologică efectuată. 9 specii bacteriene și 217 tulpini au fost izolate. Cel mai frecvent microorganism identificat a fost Staphylococcus aureus (42,4%), urmat de Pseudomonas aeruginosa (23,04%) și Proteus spp. (13,82%). Rezistență crescută la oxacilină, eritromicină și clindamicină a fost identificată la tulpinile de Staphylococcus aureus meticilino-rezistent, în timp ce tulpinile de Staphylococcus aureus meticilino-sensibil au prezentat rezistență la ampicilină, clindamicină și eritromicină. Pseudomonas spp., Klebsiella spp. și E.Coli au demonstrat rezistență la ciprofloxacină. În concluzie, rezultatele obținute subliniază importanța actualizării periodice a profilului bacterian și a susceptibilității la antibiotice în UCG. Datorită apariției tulpinilor bacteriene rezistente, este imperios necesară efectuarea de culturi bacteriene de fiecare dată când se suspectează prezența infecțiilor în UCG, înainte de inițierea antibioterapiei.

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