Clinical characteristics of COVID-19 in patients with tuberculosis and factors associated with the disease severity

Parolina, Liubov; Pshenichnaya, N.; Vasilyeva, Irina; Lizinfeld, Irina; Urushadze, Natalia; Гусева, В М; Otpuschennikova, O. N.; Dyachenko, O. V.; Kharitonov, Pavel

doi:10.1016/j.ijid.2022.04.041

Cited by 15 publications

(13 citation statements)

References 17 publications

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“…The influencing impact of being overweight, smoking, and alcohol consumption on SARS-CoV-2 testing [47] was not observed in our sample. Furthermore, we found no association between chronic diseases [50,51] and SARS-CoV-2 testing.…”

Section: Main Findingscontrasting

confidence: 69%

Effectiveness of and Inequalities in COVID-19 Epidemic Control Strategies in Hungary: A Nationwide Cross-Sectional Study

et al. 2023

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Introduction: Before the mass vaccination, epidemiological control measures were the only means of containing the COVID-19 epidemic. Their effectiveness determined the consequences of the COVID-19 epidemic. Our study evaluated the impact of sociodemographic, lifestyle, and clinical factors on patient-reported epidemiological control measures. Methods: A nationwide representative sample of 1008 randomly selected adults were interviewed in person between 15 March and 30 May 2021. The prevalence of test-confirmed SARS-CoV-2 infection was 12.1%, of testing was 33.7%, and of contact tracing among test-confirmed infected subjects was 67.9%. The vaccination coverage was 52.4%. Results: According to the multivariable logistic regression models, the occurrence of infection was not influenced by sociodemographic and lifestyle factors or by the presence of chronic disease. Testing was more frequent among middle-aged adults (aOR = 1.53, 95% CI 1.10–2.13) and employed adults (aOR = 2.06, 95% CI 1.42–3.00), and was more frequent among adults with a higher education (aORsecondary = 1.93, 95% CI 1.20–3.13; aORtertiary = 3.19, 95% CI 1.81–5.63). Contact tracing was more frequently implemented among middle-aged (aOR41-7y = 3.33, 95% CI 1.17–9.45) and employed (aOR = 4.58, 95% CI 1.38–15.22), and those with chronic diseases (aOR = 5.92, 95% CI 1.56–22.47). Positive correlation was observed between age groups and vaccination frequency (aOR41-70y = 2.94, 95% CI 2.09–4.15; aOR71+y = 14.52, 95% CI 7.33–28.77). Higher than primary education (aORsecondary = 1.69, 95% CI 1.08–2.63; aORtertiary = 4.36, 95% CI 2.46–7.73) and the presence of a chronic disease (aOR = 2.58, 95% CI 1.75–3.80) positively impacted vaccination. Regular smoking was inversely correlated with vaccination (aOR = 0.60; 95% CI 0.44–0.83). Conclusions: The survey indicated that testing, contact tracing, and vaccination were seriously influenced by socioeconomic position; less so by chronic disease prevalence and very minimally by lifestyle. The etiological role of socioeconomic inequalities in epidemic measure implementation likely generated socioeconomic inequality in COVID-19-related complication and death rates.

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Section: Main Findingscontrasting

confidence: 69%

Effectiveness of and Inequalities in COVID-19 Epidemic Control Strategies in Hungary: A Nationwide Cross-Sectional Study

et al. 2023

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“…In 2020 alone, Zambia was estimated to have a TB incidence of 319/100,000, and 39% of people with TB were also HIV-infected [ 22 ]. The TB and COVID-19 clinical symptoms, risk factors, and modes of transmission often tend to be similar [ 18 , 23 , 24 ], and because of this similarity in clinical characteristics, diagnostic difficulties arise, which may contribute to the development of severe COVID-19 [ 25 ]. The impact of COVID-19 on TB and vice versa is yet to be fully understood.…”

Section: Discussionmentioning

confidence: 99%

Superimposed Pulmonary Tuberculosis (PTB) in a 26-Year-Old Female with No Underlying Co-Morbidities Recovering from COVID-19—Case Report

et al. 2023

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Tuberculosis before the COVID-19 pandemic is said to have killed more people globally than any other communicable disease and is ranked the 13th cause of death, according to the WHO. Tuberculosis also still remains highly endemic, especially in LIMCs with a high burden of people living with HIV/AIDS, in which it is the leading cause of mortality. Given the risk factors associated with COVID-19, the cross similarities between tuberculosis and COVID-19 symptoms, and the paucity of data on how both diseases impact each other, there is a need to generate more information on COVID-19–TB co-infection. In this case report, we present a young female patient of reproductive age with no underlying comorbidities recovering from COVID-19, who later presented with pulmonary tuberculosis. It describes the series of investigations performed and treatments given during the follow-up. There is a need for more surveillance for possible COVID-19–TB co-infection cases and further research to understand the impact of COVID-19 on tuberculosis and vice versa, especially in LMICs.

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“…Pasien dengan pulmonary bilateral disseminated TB memiliki risiko kematian yang lebih tinggi. 9 Kapoor dkk. (2021) menunjukkan hasil yang paling dominan adalah demam (89,2%), dan 64 (53,3%) mengalami malnutrisi akut parah.…”

Section: Bunclassified

Scoping Review: Gejala Klinis Pasien Covid-19 dengan Koinfeksi Tuberkulosis

Wicaksana¹,

Maharani

Garina

2023

BCSMS

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Abstract. Coronavirus disease 2019 (COVID-19) and tuberculosis (TB) are infectious diseases that can be transmitted by droplets. The clinical manifestations of COVID-19 disease can worsen if there are comorbidities, one of which is TB disease. Epidemiologically, COVID-19 and TB are two diseases with a very high incidence and are a global health problem. The study aims to analyze the impact of TB co-infection on the clinical symptoms of COVID-19 patients. This research uses the scoping review method using scientific articles published in three databases SciencDirect, SpringerLink, and Pubmed in 2019-2022. In the data search, 2,773 articles were obtained with the acquisition of 404 articles that met the inclusion criteria and 6 articles after PICOS analysis was carried out. The results showed that the dominant clinical symptoms that occurred at all ages were respiratory symptoms, fever, cough, chest pain, and dyspnea. In addition, there are additional clinical symptoms in pediatric patients in the form of nausea, diarrhea, headache, tachypnoea, and altered sensorium (impaired awareness, attention or difficulty focusing thoughts). Other results describe an increase in the release of cytokines (IFN-γ, TNF, IL-4, and IL-13) against both pathogens resulting in a "cytokine storm" that can affect the clinical symptoms of patients. The conclusion of this study shows that COVID-19 and TB infection have an adverse clinical impact on patients. Abstrak. Penyakit virus corona atau Corona virus disease (COVID-19) dan tuberkulosis (TB) merupakan suatu penyakit menular yang dapat ditransmisikan melalui droplet. Manifestasi klinik penyakit COVID-19 dapat memburuk bila terdapat komorbiditas salah satunya adalah penyakit TB. Secara epidemiologi penyakit COVID-19 dan TB merupakan dua penyakit dengan angka kejadian sangat tinggi yang menjadi masalah kesehatan dunia. Penelitian ini bertujuan untuk menganalisis dampak dari koinfeksi TB terhadap gejala klinis pasien COVID-19. Penelitian ini menggunakan metode scoping review menggunakan artikel ilmiah yang dipublikasikan pada tiga database SciencDirect, SpringerLink, dan Pubmed pada tahun 2019-2022. Pada pencarian data didapatkan 2,773 artikel dengan didapatkan 404 artikel yang sesuai dengan kriteria inklusi dan 6 artikel setelah dilakukan analisis PICOS. Hasil penelitian menunjukkan gejala klinis yang dominan terjadi pada semua usia adalah gejala saluran pernapasan, demam, batuk, nyeri dada, dan dispnea. Selain itu terdapat gejala klinis tambahan pada pasien anak berupa mual, diare, nyeri kepala, takipnea, dan gangguan system saraf seperti gangguan kesadaran, perhatian atau kesulitan memfokuskan pikiran. Hasil lain menggambarkan peningkatkan pengeluaran sitokin (IFN-γ, TNF, IL-4, dan IL-13) untuk melawan kedua patogen sehingga mengakibatkan “cytokine storm” yang dapat memperburuk gejala klinis pasien. Simpulan penelitian ini menunjukkan koinfeksi COVID-19 dan TB memperburuk dampak klinis pada pasien.

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Clinical characteristics of COVID-19 in patients with tuberculosis and factors associated with the disease severity

Cited by 15 publications

References 17 publications

Effectiveness of and Inequalities in COVID-19 Epidemic Control Strategies in Hungary: A Nationwide Cross-Sectional Study

Effectiveness of and Inequalities in COVID-19 Epidemic Control Strategies in Hungary: A Nationwide Cross-Sectional Study

Superimposed Pulmonary Tuberculosis (PTB) in a 26-Year-Old Female with No Underlying Co-Morbidities Recovering from COVID-19—Case Report

Scoping Review: Gejala Klinis Pasien Covid-19 dengan Koinfeksi Tuberkulosis

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