Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 in Wuhan, China: a retrospective study

Deng, Yan; Liu, Wei; Liu, Kui; Fang, Yuan; Shang, Jin; Zhou, Ling; Wang, Ke; Fan, Li; Wei, Shuang; Chen, Lei; Liu, Hui Guo

doi:10.1097/cm9.0000000000000824

Cited by 631 publications

(761 citation statements)

References 29 publications

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“…Increasing number of reports and clinical observations demonstrate that patients infected with SARS-CoV-2 present not only respiratory signs of infection but also diarrhoea, vomiting, nausea or abdominal pain. [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] showed ground-glass opacities in CT scan and was afterwards tested positive from nasopharyngeal swab. 22 Interestingly, the first described case of COVID-19 in United…”

Section: Covid-19 and Gastrointestinal Tractmentioning

confidence: 99%

COVID‐19: Focus on the lungs but do not forget the gastrointestinal tract

Smyk

Janik

Portincasa

et al. 2020

Eur J Clin Investigation

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The coronavirus disease 2019 (COVID‐19) caused by SARS‐CoV‐2 was declared in the last weeks as global pandemic. Currently affecting more than 5 000 000 individuals worldwide, COVID‐19 is most commonly associated with symptoms caused by the acute respiratory distress syndrome (ARDS). As the number of infected individuals increases, we are learning that not only lungs, but also other organs can be affected by the virus. The gastrointestinal symptoms, for example diarrhoea, vomiting, nausea or abdominal pain, are frequent in patients with COVID‐19. Moreover, alimentary tract symptoms may precede the respiratory presentation of SARS‐CoV‐2 infection. This can lead to delayed diagnosis and inappropriate management of infected patients. In addition, SARS‐CoV‐2 nucleic acid can be detected in faeces of infected patients and rectal swabs are even reported to remain positive for a longer period of time than nasopharyngeal swabs. Here, we aim to provide an update on the gastrointestinal involvement of COVID‐19 presenting the symptoms that can be encountered in infected patients. We address the role of angiotensin‐converting enzyme 2 (ACE2), as a functional receptor for SARS‐CoV‐2, which also was found in the gastrointestinal tract. Finally, we briefly discuss faecal shedding of SARS‐CoV‐2 and its potential role in the pathogenesis of the disease.

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Section: Covid-19 and Gastrointestinal Tractmentioning

confidence: 99%

COVID‐19: Focus on the lungs but do not forget the gastrointestinal tract

Smyk

Janik

Portincasa

et al. 2020

Eur J Clin Investigation

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“…SARS, MERS and COVID-19 can cause intestinal, respiratory, neuronal and hepatic diseases, and may lead to respiratory distress syndrome, organ failure, and even death in severe cases [5][6][7] . Several studies have reported the clinical characteristics and laboratory findings associated with different degrees of liver injury in patients with COVID-19 infection [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] . We are aware of no meta-analysis that summarized available findings in this regard.…”

Section: Introductionmentioning

confidence: 99%

Liver injury is associated with severe coronavirus disease 2019 (COVID‐19) infection: A systematic review and meta‐analysis of retrospective studies

Parohan

Yaghoubi

Seraji

2020

Hepatology Research

129

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Aim: The Coronavirus disease 2019 (COVID-19) outbreak is a major threat to human beings.Lung injury has been reported as the major outcome of COVID-19 infection. However, liver damage has also been considered to occur in severe cases. Current meta-analysis of retrospective studies was done to summarize available findings on the association between liver injury and severity of COVID-19 infection.Methods: Online databases including PubMed, Scopus, Web of Science and Cochrane Library were searched to detect relevant publications up to 1 April 2020, using relevant keywords. To pool data, a fixed-or random-effects model was used depending on the heterogeneity between studies. Furthermore, publication bias test and sensitivity analysis were also done.Results: In total, 20 retrospective studies with 3,428 COVID-19 infected patients (severe cases = 1,455 and mild cases = 1,973), were included in this meta-analysis. Higher serum levels of Aspartate aminotransferase (weighted mean difference = 8.84 U/L, 95% CI = 5.97 to 11.71, P<0.001), Alanine aminotransferase (weighted mean difference = 7.35 U/L, 95% CI = 4.77 to 9.93, P<0.001), total Bilirubin (weighted mean difference = 2.30 mmol/L, 95% CI = 1.24 to 3.36, P<0.001) and lower serum levels of Albumin (weighted mean difference = -4.24 g/L, 95% CI = -6.20 to -2.28, P<0.001), were associated with a significant increase in the severity of COVID-19 infection. This article is protected by copyright. All rights reserved.Conclusions: The incidence of liver injury, as assessed by serum analysis (AST, ALT, total Bilirubin and Albumin levels), seems to be higher in patients with severe COVID-19 infection.

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“…(58)ThrombosisOne of the prominent findings replicated across most early studies of COVID-19 includes disarray of the coagulation and fibrinolytic system. Hospitalized patients with moderate and severe COVID-19 and those with poorer outcomes are noted to have prolonged prothrombin time (PT), elevated D-dimer, and activated partial thromboplastin time (APTT) (35,53,54,64). In the context of a clinical picture that is consistent with disseminated intravascular thrombosis, it is reasonable to speculate that COVID-19 would be associated with venous or arterial thrombi, however the incidence has not been published.…”

mentioning

confidence: 99%

COVID-19 for the Cardiologist

Atri

Siddiqi

Lang

et al. 2020

JACC: Basic to Translational Science

268

137

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Highlights-Severe acute respiratory virus-2 (SARS-CoV2), the infection responsible for coronavirus disease-2019 (COVID-19), has spread globally leading to a devastating loss of life. In a few short months, the clinical and scientific communities have rallied to rapidly evolve our understanding of the mechanism(s) of disease and potential therapeutics. -This review discusses the current understanding of the basis virology of SARS-CoV2 and the epidemiology, clinical manifestations, including cardiovascular, and mortality of COVID-19. A detailed review of the viral life cycle and putative mechanism(s) of injury frames the discussion of possible preventative and therapeutic strategies. -The ongoing, unprecedented collective effort will, without a doubt, advance our ability to prevent the spread and optimally care for patients suffering from COVID-19. SummaryThe coronavirus disease-2019 (COVID-19), a contagious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV2), has reached pandemic status. As it spreads across the world, it has overwhelmed healthcare systems, strangled the global economy and led to a devastating loss of life. Widespread efforts from regulators, clinicians and scientists are driving a rapid expansion of knowledge of the SARS-CoV2 virus and the COVID-19 disease.We review the most current data with a focus on our basic understanding of the mechanism(s) of disease and translation to the clinical syndrome and potential therapeutics. We discuss the basic virology, epidemiology, clinical manifestation, multi-organ consequences, and outcomes. With a focus on cardiovascular complications, we propose several mechanisms of injury. The virology and potential mechanism of injury form the basis for a discussion of potential disease-modifying therapies.

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Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 in Wuhan, China: a retrospective study

Cited by 631 publications

References 29 publications

COVID‐19: Focus on the lungs but do not forget the gastrointestinal tract

COVID‐19: Focus on the lungs but do not forget the gastrointestinal tract

Liver injury is associated with severe coronavirus disease 2019 (COVID‐19) infection: A systematic review and meta‐analysis of retrospective studies

COVID-19 for the Cardiologist

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