Clinical characteristics of Japanese children with optic neuritis

Mizota, Atsushi; Niimura, Miyoko

doi:10.1016/j.pediatrneurol.2003.11.011

Cited by 28 publications

(20 citation statements)

References 16 publications

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“…9,11 However, the rate of developing MS after pediatric optic neuritis also varied with race (Table 4). In comparison with other Asian countries, the rate of developing MS was 12.5% in our study, which was higher than Korean (4%), 15 and Thai (9.1%), 14 but was much lower than that reported in Japanese (31.7%), 17 and another recent Korean study (25%). 19 One of the reasons for wide range of conversion rate in each study might be due to different follow-up period.…”

Section: Discussioncontrasting

confidence: 81%

“…8,11,12,14,15,17,19 According to these reports, 77-90% of patients attained final VA of 20/40 or better. In addition, optic neuritis in childhood had more bilateral, female involvement, disc swelling at presentation, and was frequently associated with preceding viral infection.…”

Section: Discussionmentioning

confidence: 99%

“…[8][9][10] However, there have been accumulating reports with different clinical characteristics of optic neuritis and MS in Europe, 11,12 North America, 8,9,13 and Asia. [14][15][16][17] Herein we report a retrospective study to evaluate the clinical characteristics of children with optic neuritis in Taiwan. Meanwhile, the specific aim of this study was to statistically document the factors relevant to visual prognosis in optic neuritis in children.…”

Section: Introductionmentioning

confidence: 99%

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Clinical characteristics of optic neuritis in Taiwanese children

Sun

et al. 2011

Eye

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Section: Discussioncontrasting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical characteristics of optic neuritis in Taiwanese children

Sun

et al. 2011

Eye

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“…These were further reviewed, and 14 studies met the inclusion criteria. The average number of patients (with individual patient data) included per study was 16 (range, 4-41; Table 1 4,7,8,[10][11][12][13][14][15][16][17][18][19][20].…”

Section: Resultsmentioning

confidence: 99%

“…4,16 There was no mention of whether an MRI was obtained in 2 studies (totaling 49 children). 13,14 For the remaining 93 children, an abnormal MRI (defined as white matter lesions outside the optic nerves and chiasm using T2-weighted and FLAIR sequences) was seen in 40 children (43%). The demographics for children with and without MRI data available are presented in Table 4.…”

Section: Resultsmentioning

confidence: 99%

Pediatric optic neuritis and risk of multiple sclerosis: Meta-analysis of observational studies

Waldman

Stull

Galetta

et al. 2011

Journal of American Association for Pediatric Ophthalmology and

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Assessment of Pediatric Optic Neuritis Visual Acuity Outcomes at 6 Months

et al. 2020

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IMPORTANCE Optic neuritis (ON) in children is uncommon. There are limited prospective data for visual acuity (VA) outcomes, associated diseases, and neuroimaging findings. Prospective data from a large sample would be useful for counseling families on treatment decisions and prognosis.OBJECTIVE To prospectively study children with a first episode of ON, describe VA after 6 months, and ascertain the network's (Pediatric Eye Disease Investigator Group and Neuro-Ophthalmology Research Disease Investigator Consortium) ability to enroll pediatric patients with ON prospectively. DESIGN, SETTING, AND PARTICIPANTSThis nonrandomized cohort study was conducted from September 20, 2016, to July 20, 2018, at 23 sites in the United States and Canada in pediatric ophthalmology or neuro-ophthalmology clinics. A total of 44 children (aged 3-15 years) presented with a first episode of ON (visual loss, pain on eye movements, or both) within 2 weeks of symptom onset and at least 1 of the following in the affected eye: a distance high-contrast VA (HCVA) deficit of at least 0.2 logMAR below age-based norms, diminished color vision, abnormal visual field, or optic disc swelling. Exclusion criteria included preexisting ocular abnormalities or a previous episode of ON.MAIN OUTCOMES AND MEASURES Primary outcomes were monocular HCVA and low-contrast VA at 6 months. Secondary outcomes were neuroimaging, associated diagnoses, and antibodies for neuromyelitis optica and myelin oligodendrocyte glycoprotein.RESULTS A total of 44 children (mean age [SD], 10.2 [3.5] years; 26 boys [59%]; 23 White individuals [52%]; 54 eyes) were enrolled in the study. Sixteen patients (36%) had bilateral ON. Magnetic resonance imaging revealed white matter lesions in 23 children (52%). Of these children, 8 had myelin oligodendrocyte glycoprotein-associated demyelination (18%), 7 had acute disseminated encephalomyelitis (16%), 5 had multiple sclerosis (11%), and 3 had neuromyelitis optica (7%). The baseline mean HCVA was 0.95 logMAR (20/200), which improved by a mean 0.76 logMAR (95% CI, 0.54-0.99; range, -0.70 to 1.80) to 0.12 logMAR (20/25) at 6 months. The baseline mean distance low-contrast VA was 1.49 logMAR (20/640) and improved by a mean 0.72 logMAR (95% CI, 0.54-0.89; range, -0.20 to 1.50) to 0.73 logMAR (20/100) at 6 months. Baseline HCVA was worse in younger participants (aged <10 years) with associated neurologic autoimmune diagnoses, white matter lesions, and in those of non-White race and non-Hispanic ethnicity. The data did not suggest a statistically significant association between baseline factors and improvement in HCVA. CONCLUSIONS AND RELEVANCEThe study network did not reach its targeted enrollment of 100 pediatric patients with ON over 2 years. This indicates that future treatment trials may need to use different inclusion criteria or plan a longer enrollment period to account for the rarity of the disease. Despite poor VA at presentation, most children had marked improvement by 6 months. Associated neurologic autoimmune diagnoses were common. ...

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Clinical characteristics of Japanese children with optic neuritis

Cited by 28 publications

References 16 publications

Clinical characteristics of optic neuritis in Taiwanese children

Clinical characteristics of optic neuritis in Taiwanese children

Pediatric optic neuritis and risk of multiple sclerosis: Meta-analysis of observational studies

Assessment of Pediatric Optic Neuritis Visual Acuity Outcomes at 6 Months

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