Pediatric optic neuritis and risk of multiple sclerosis: Meta-analysis of observational studies

Neurological outcome and predictive factors of idiopathic optic neuritis in China

“…There are a few possible explanations for this lower conversion rate of our ION patients. First of all, our study group had a higher proportion (approximately 40%) of pediatric cases, who are believed to carry a lower risk of converting to MS [1,21,22]. Second, the occurrence of swollen discs, associated with less likelihood of developing into MS, was frequently observed (43%) in our patients.…”

Optic Neuritis in Korean Children: Low Risk of Subsequent Multiple Sclerosis

“…7 The reported conversion rate of pediatric optic neuritis to multiple sclerosis has varied been 6% and 36%. 6,7,[16][17][18][19][20] The incidence of multiple sclerosis in Korea is 0.1 per 100,0000. 11 The association of multiple sclerosis and adult optic neuritis in Korea is not known.…”

“…[5][6][7] Bilateral optic neuritis and papillitis are more common in children, and childhood optic neuritis is frequently associated with systemic infections or vaccinations. [7][8][9][10] In addition, optic neuritis in children has a better visual prognosis and a lower risk of a subsequent diagnosis of multiple sclerosis than that in adults. 7 The clinical characteristics of optic neuritis and multiple sclerosis have been reported to vary by race.…”

“…[7][8][9][10] In addition, optic neuritis in children has a better visual prognosis and a lower risk of a subsequent diagnosis of multiple sclerosis than that in adults. 7 The clinical characteristics of optic neuritis and multiple sclerosis have been reported to vary by race. Multiple sclerosis is rare in Korea, Japan, and China, 11,12 and the prognosis for optic neuritis in these countries is quite different from that in Europe or North America.…”

Pediatric optic neuritis and multiple sclerosis: Who is at risk for progression?

“…There has been no prospective study of optic neuritis in children to help us to address these risk factors. Thus in this issue of the Journal of AAPOS, Waldman and colleagues 3 have undertaken a meta-analysis of pediatric optic neuritis studies with the hypotheses that (1) MRI abnormalities and (2) unilateral presentation are both risk factors for MS progression. This group previously reported an increased risk of MS in patients with optic neuritis and MRI abnormalities, 4 and they also found that none of their patients with bilateral optic neuritis progressed to MS.…”