Neurological outcome and predictive factors of idiopathic optic neuritis in China

Peng, Jingting; Cong, Hengri; Yan, Rong; Kong, Xiu-yun; Jiang, Hanqiu; Wei, Wenbin; Zhang, Xiaojun

doi:10.1016/j.jns.2014.12.031

Cited by 10 publications

(4 citation statements)

References 26 publications

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“…It is somewhat surprising that one-third of our patients had bilateral ON involvement at the onset. These results are consistent with previous studies done in Asian countries and suggest that this situation could be related to genetic and environmental factors [17]. Vitamin D deficiency was detected in most of the patients and this high prevalence seems to be related to the cultural characteristics of the geographical region we live in.…”

Section: Discussionsupporting

confidence: 92%

Conversion of Optic Neuritis to Relapsing Remitting Multiple Sclerosis: A Retrospective Comorbidity Cohort Study

Köseoğlu

Tutuncu²

2020

Eur Neurol

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The aim of the study was to determine the risk of multiple sclerosis (MS) conversion after optic neuritis (ON) and to identify the predictive factors on conversion in Turkish patients. Methods: Patients whose first clinical attacks had been ON were included in the study. The primary end point was the diagnosis of clinical relapse-remitting MS. Result: Except for the bilateral involvement rate, the clinical and demographic characteristics of the cohort are similar to Western studies. Though one-third of the patients with ON had bilateral involvement, bilateral involvement reduces the risk of conversion. Also, active lesions at the initial cranial magnetic resonance imagination increase the conversion rate. Conclusion: This research confirms previous findings and contributes additional evidence that if the patients have unilateral involvement and active lesions, they should be closely monitored. Moreover, our research supports the hypothesis that risk factors may be affected by racial, environmental, and genetic factors.

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Section: Discussionsupporting

confidence: 92%

Conversion of Optic Neuritis to Relapsing Remitting Multiple Sclerosis: A Retrospective Comorbidity Cohort Study

Köseoğlu

Tutuncu²

2020

Eur Neurol

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“…Acute optic neuritis may be the first manifestation of both multiple sclerosis (MS) and neuromyelitis optica (NMO), or some unknown etiology of disorders [ 1 , 2 ]. In Chinese, the demographic and clinical features of optic neuritis spectrum disorder are less well-defined than that in Caucasus [ 3 – 5 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Retinal Nerve Fiber Layer and Ganglion Cell Complex in Patients with Optic Neuritis or Neuromyelitis Optica Spectrum Disorders Using Optical Coherence Tomography in a Chinese Cohort

Tian

Zhao

et al. 2015

Journal of Ophthalmology

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We evaluate a cohort of optic neuritis and neuromyelitis optica (NMO) spectrum disorders patients in a territory hospital in China. The peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell complex (GCC) were measured using spectral-domain OCT after 6 months of acute onset. The results showed that both the peripapillary RNFL and macular GCC were significantly thinner in all optic neuritis subtypes compared to controls. In addition, the recurrent optic neuritis and NMO groups showed more severe damage on the RNFL and GCC pattern.

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“…Previous studies have reported several risk factors, such as the presence of molecular biomarkers in CSF, which are associated with the development of CDMS after optic neuritis (2,13,27,28). However, in clinical practice, MRI is the main procedure that is routinely used for assessments.…”

Section: Discussionmentioning

confidence: 99%

Development of a Prognostic Model for Predicting Multiple Sclerosis After Optic Neuritis: A Secondary Analysis of Data From the Optic Neuritis Treatment Trial

Luo¹,

Deng²,

Xu³

et al. 2021

Journal of Neuro-Ophthalmology

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Background:Optic neuritis can be the initial manifestation of multiple sclerosis (MS). The purpose of this study was to develop a prognostic model for predicting the risk of MS development among patients with optic neuritis.Methods:The data from 388 patients with optic neuritis were retrieved from the Optic Neuritis Treatment Trial (ONTT). Cox proportional hazards regression analysis was used to develop a prognostic model. The performance of the model was assessed by using Harrell's C-index and calibration curves. The rates of MS development were estimated using the Kaplan–Meier method.Results:Among the enrolled subjects, a total of 154 (39.7%) patients developed clinically definite MS during a median follow-up period of 15.8 years (interquartile range, 7.2–16.9 years). The factors associated with the development of MS were the presence of brain lesions as on baseline MRI, previous nonspecific neurologic symptoms, commencing low-dose corticosteroids treatment, ocular pain, and absence of optic disc/peripapillary hemorrhage. After incorporating these 5 factors into the prognostic model, a C-index of 0.72 (95% confidence interval [CI], 0.69–0.76) and good calibration curves were obtained. The C-index of the model was significantly higher than the C-indexes of any single factor (P < 0.001 in all cases). The model was able to stratify the ONTT patient cohort into 3 risk groups with significantly different intergroup rates of developing MS (rates for developing MS within a 15-year period: high-risk group, 75.7% [95% CI, 65.6%–82.9%], intermediate-risk group, 44.7% [95% CI, 31.4%–55.4%]; and low-risk group, 20.8% [95% CI, 14.2%–26.8%]; log-rank P < 0.001).Conclusions:This prognostic model had a better prediction ability when compared with the standard practice that relies solely on using brain lesions on MRI. It can, therefore, help guide decision-making to initiate earlier disease-modifying therapy for patients with optic neuritis at risk of developing MS.

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Neurological outcome and predictive factors of idiopathic optic neuritis in China

Cited by 10 publications

References 26 publications

Conversion of Optic Neuritis to Relapsing Remitting Multiple Sclerosis: A Retrospective Comorbidity Cohort Study

Conversion of Optic Neuritis to Relapsing Remitting Multiple Sclerosis: A Retrospective Comorbidity Cohort Study

Evaluation of Retinal Nerve Fiber Layer and Ganglion Cell Complex in Patients with Optic Neuritis or Neuromyelitis Optica Spectrum Disorders Using Optical Coherence Tomography in a Chinese Cohort

Development of a Prognostic Model for Predicting Multiple Sclerosis After Optic Neuritis: A Secondary Analysis of Data From the Optic Neuritis Treatment Trial

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